RADx-rad / Diagnostics Portal

Written by Devora Najjar, Joshua Rainbow, Sanjay Sharma Timilsina, Pawan Jolly, Helena de Puig, Mohamed Yafia, Nolan Durr, Hani Sallum, Galit Alter, Jonathan Z Li, Xu G Yu, David R Walt, Joseph A Paradiso, Pedro Estrela, James J Collins, Donald E Ingber

Nat Biomed Eng

August 8, 2022

Rapid, accurate and frequent detection of the RNA of SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) and of serological host antibodies to the virus would facilitate the determination of the…

CRISPR-Cas12a-Empowered Electrochemical Biosensor for Rapid and Ultrasensitive Detection of SARS-CoV-2 Delta Variant.

Written by Chenshuo Wu, Zhi Chen, Chaozhou Li, Yabin Hao, Yuxuan Tang, Yuxuan Yuan, Luxiao Chai, Taojian Fan, Jiangtian Yu, Xiaopeng Ma, Omar A Al-Hartomy, S Wageh, Abdullah G Al-Sehemi, Zhiguang Luo, Yaqing He, Jingfeng Li, Zhongjian Xie, Han Zhang

Nanomicro Lett

August 4, 2022

Coronavirus disease 2019 (COVID-19) is a highly contagious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The gold standard method for the diagnosis of SARS-CoV-2 depends on quantitative…

A gold nanoparticle-protein G electrochemical affinity biosensor for the detection of SARS-CoV-2 antibodies: a surface modification approach.

Written by Yeganeh Khaniani, Yuhao Ma, Mahdi Ghadiri, Jie Zeng, David Wishart, Shawn Babiuk, Carmen Charlton, Jamil N Kanji, Jie Chen

Sci Rep

July 27, 2022

As COVID-19 waves continue to spread worldwide, demand for a portable, inexpensive and convenient biosensor to determine community immune/infection status is increasing. Here we describe an impedance-based affinity biosensor using…

Highly sensitive aptasensor for the detection of SARS-CoV-2-RBD using aptamer-gated methylene blue@mesoporous silica film/laser engraved graphene electrode.

Written by Mahmoud Amouzadeh Tabrizi, Pablo Acedo

July 16, 2022

Herein, an aptasensor was designed to detect the receptor-binding domain of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2-RBD) based on the encapsulation of the methylene blue (MB) inside the mesoporous silica…

Recent Progresses in Electrochemical DNA Biosensors for SARS-CoV-2 Detection.

Written by Yanqiu Mei, Xiaofeng Lin, Chen He, Weijia Zeng, Yan Luo, Chenghao Liu, Zhehao Liu, Min Yang, Ying Kuang, Qitong Huang

Front Bioeng Biotechnol

July 15, 2022

Coronavirus disease 19 (COVID-19) is still a major public health concern in many nations today. COVID-19 transmission is now controlled mostly through early discovery, isolation, and therapy. Because of the…

Recent Progresses in Electrochemical DNA Biosensors for SARS-CoV-2 Detection.

Written by Yanqiu Mei, Xiaofeng Lin, Chen He, Weijia Zeng, Yan Luo, Chenghao Liu, Zhehao Liu, Min Yang, Ying Kuang, Qitong Huang

Front Bioeng Biotechnol

July 15, 2022

A comparison of conventional and advanced electroanalytical methods to detect SARS-CoV-2 virus: A concise review.

Written by Pattan-Siddappa Ganesh, Sang-Youn Kim

Chemosphere

July 8, 2022

Respiratory viruses are a serious threat to human wellbeing that can cause pandemic disease. As a result, it is critical to identify virus in a timely, sensitive, and precise manner.…

A comparison of conventional and advanced electroanalytical methods to detect SARS-CoV-2 virus: A concise review.

Written by Pattan-Siddappa Ganesh, Sang-Youn Kim

Chemosphere

July 8, 2022

Respiratory viruses are a serious threat to human wellbeing that can cause pandemic disease. As a result, it is critical to identify virus in a timely, sensitive, and precise manner.…

An impedimetric biosensor for COVID-19 serology test and modification of sensor performance via dielectrophoresis force.

Written by Jie Zeng, Pedro A Duarte, Yuhao Ma, Oleksandra Savchenko, Lian Shoute, Yeganeh Khaniani, Shawn Babiuk, Ran Zhuo, Gaser N Abdelrasoul, Carmen Charlton, Jamil N Kanji, Lorne Babiuk, Cole Edward, Jie Chen

June 10, 2022

Coronavirus disease 2019 (COVID-19) has caused significant global morbidity and mortality. The serology test that detects antibodies against the disease causative agent, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2),…

Aerosol-jet-printed graphene electrochemical immunosensors for rapid and label-free detection of SARS-CoV-2 in saliva.

Written by Cícero C Pola, Sonal V Rangnekar, Robert Sheets, Beata M Szydlowska, Julia R Downing, Kshama W Parate, Shay G Wallace, Daphne Tsai, Mark C Hersam, Carmen L Gomes, Jonathan C Claussen

2d Mater

June 10, 2022

Rapid, inexpensive, and easy-to-use coronavirus disease 2019 (COVID-19) home tests are key tools in addition to vaccines in the world-wide fight to eliminate national and local shutdowns. However, currently available…

Aerosol-jet-printed graphene electrochemical immunosensors for rapid and label-free detection of SARS-CoV-2 in saliva.

Written by Cícero C Pola, Sonal V Rangnekar, Robert Sheets, Beata M Szydlowska, Julia R Downing, Kshama W Parate, Shay G Wallace, Daphne Tsai, Mark C Hersam, Carmen L Gomes, Jonathan C Claussen

2d Mater

June 10, 2022

Ultralight, Safe, Economical, and Portable Oxygen Generators with Low Energy Consumption Prepared by Air-Breathing Electrochemical Extraction.

ACS Appl Mater Interfaces

Written by Lei He, Miao Gao, Fandi Ning, Chuang Bai, Saifei Pan, Hanqing Jin, Qinglin Wen, Xiaochun Zhou

June 7, 2022

Pure oxygen is vital in medical treatment, first aid, and chemical synthesis. Hypoxia can cause severe damage to the organ systems such as respiratory, digestive, and nervous systems and even…

Electrochemical Impedance-Based Biosensors for the Label-Free Detection of the Nucleocapsid Protein from SARS-CoV-2.

Written by Hana Cho, Suhyun Shim, Won Woo Cho, Sungbo Cho, Hanseung Baek, Sang-Myung Lee, Dong-Sik Shin

ACS Sens

June 2, 2022

Diagnosis of coronavirus disease (COVID-19) is important because of the emergence and global spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Real-time polymerase chain reaction (PCR) is widely used…

Label free detection of SARS CoV-2 Receptor Binding Domain (RBD) protein by fabrication of gold nanorods deposited on electrochemical immunosensor (GDEI).

Written by Deepshikha Shahdeo, Akanksha Roberts, G J Archana, Narlawar Sagar Shrikrishna, Subhasis Mahari, K Nagamani, Sonu Gandhi

May 20, 2022

Coronavirus Disease 2019 (COVID-19) pandemic has shown the need for early diagnosis to manage infectious disease outbreaks. Here, we report a label free electrochemical Fluorine-Doped Tin Oxide (FTO) Immunosensor coupled…

Nanodiamond conjugated SARS-CoV-2 spike protein: electrochemical impedance immunosensing on a gold microelectrode.

Written by Santheraleka Ramanathan, Subash C B Gopinath, Zool Hilmi Ismail, Sreeramanan Subramaniam

Mikrochim Acta

May 20, 2022

A promising immunosensing strategy in diagnosing SARS-CoV-2 is proposed using a 10-µm gap-sized gold interdigitated electrode (AuIDE) to target the surface spike protein (SP). The microelectrode surface was modified by…

Multiplexed biosensor for point-of-care COVID-19 monitoring: CRISPR-powered unamplified RNA diagnostics and protein-based therapeutic drug management

Preprint

Written by Midori Johnston, H. Ceren Ates, Regina T. Glatz, Hasti Mohsenin, Rosanne Schmachtenberg, Nathalie Göppert, Daniela Huzly, Gerald A. Urban, Wilfried Weber, Can Dincer

April 6, 2022

In late 2019 SARS-CoV-2 rapidly spread to become a global pandemic, therefore, measures to attenuate chains of infection, such as high-throughput screenings and isolation of carriers were taken. Prerequisite for…

DNA Hairpins and Dumbbell-Wheel Transitions Amplified Walking Nanomachine for Ultrasensitive Nucleic Acid Detection.

Written by Peng Miao, Hua Chai, Yuguo Tang

ACS Nano

March 22, 2022

Nucleic acids, including circulating tumor DNA (ctDNA), microRNA, and virus DNA/RNA, have been widely applied as potential disease biomarkers for early clinical diagnosis. In this study, we present a concept…

DNA Hairpins and Dumbbell-Wheel Transitions Amplified Walking Nanomachine for Ultrasensitive Nucleic Acid Detection.

Written by Peng Miao, Hua Chai, Yuguo Tang

ACS Nano

March 22, 2022

Graphene-based hybrid electrical-electrochemical point-of-care device for serologic COVID-19 diagnosis.

Written by Isabela A Mattioli, Karla R Castro, Lucyano J A Macedo, Graziela C Sedenho, Mona N Oliveira, Iris Todeschini, Phelipe M Vitale, Suzete Cleusa Ferreira, Erika R Manuli, Geovana M Pereira, Ester C Sabino, Frank N Crespilho

March 1, 2022

The outbreak of COVID-19 pandemics highlighted the need of sensitive, selective, and easy-to-handle biosensing devices. In the contemporary scenario, point-of-care devices for mass testing and infection mapping within a population…

Molecularly imprinted polymer based electrochemical sensor for quantitative detection of SARS-CoV-2 spike protein.

Written by Akinrinade George Ayankojo, Roman Boroznjak, Jekaterina Reut, Andres Öpik, Vitali Syritski

Sens Actuators B Chem

February 15, 2022

The continued spread of the coronavirus disease and prevalence of the global pandemic is exacerbated by the increase in the number of asymptomatic individuals who unknowingly spread the SARS-CoV-2 virus.…

COVID-19 diagnosis by SARS-CoV-2 Spike protein detection in saliva using an ultrasensitive magneto-assay based on disposable electrochemical sensor.

Written by Evair D Nascimento, Wilson T Fonseca, Tássia R de Oliveira, Camila R S T B de Correia, Vitor M Faça, Beatriz P de Morais, Virginia C Silvestrini, Henrique Pott-Junior, Felipe R Teixeira, Ronaldo C Faria

Sens Actuators B Chem

February 15, 2022

The outbreak of the COVID-19 pandemic, caused by Severe Acute Respiratory Syndrome of Coronavirus 2 (SARS-CoV-2), has fueled the search for diagnostic tests aiming at the control and reduction of…

A review on corona virus disease 2019 (COVID-19): current progress, clinical features and bioanalytical diagnostic methods.

Written by Fariba Mollarasouli, Nader Zare-Shehneh, Mehrorang Ghaedi

Mikrochim Acta

February 14, 2022

A new epidemic of acute respiratory viral pneumonia was discovered in central China at the end of 2019. The disease was given the name coronavirus disease 2019 (COVID-19), and the…

Aptasensing nucleocapsid protein on nanodiamond assembled gold interdigitated electrodes for impedimetric SARS-CoV-2 infectious disease assessment.

Written by Santheraleka Ramanathan, Subash C B Gopinath, Zool Hilmi Ismail, M K Md Arshad, Prabakaran Poopalan

February 1, 2022

In an aim of developing portable biosensor for SARS-CoV-2 pandemic, which facilitates the point-of-care aptasensing, a strategy using 10 μm gap-sized gold interdigitated electrode (AuIDE) is presented. The silane-modified AuIDE…

Magnet-assisted electrochemical immunosensor based on surface-clean Pd-Au nanosheets for sensitive detection of SARS-CoV-2 spike protein.

Written by Jialin Zhao, Fu Zhao, Haolin Li, Youlin Xiong, Shuangfei Cai, Chen Wang, Yunfa Chen, Ning Han, Rong Yang

Electrochim Acta

February 1, 2022

Tracking and monitoring of low concentrations of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can effectively control asymptomatic transmission of current coronavirus disease 2019 (COVID-19) in the early stages of…

SARS-CoV-2 Aptasensors Based on Electrochemical Impedance Spectroscopy and Low-Cost Gold Electrode Substrates.

Written by Perrine Lasserre, Banushan Balansethupathy, Vincent J Vezza, Adrian Butterworth, Alexander Macdonald, Ewen O Blair, Liam McAteer, Stuart Hannah, Andrew C Ward, Paul A Hoskisson, Alistair Longmuir, Steven Setford, Eoghan C W Farmer, Michael E Murphy, Harriet Flynn, Damion K Corrigan

Anal Chem

February 1, 2022

SARS-CoV-2 diagnostic practices broadly involve either quantitative polymerase chain reaction (qPCR)-based nucleic amplification of viral sequences or antigen-based tests such as lateral flow assays (LFAs). Reverse transcriptase-qPCR can detect viral…

Molecularly imprinted polypyrrole based sensor for the detection of SARS-CoV-2 spike glycoprotein.

Written by Vilma Ratautaite, Raimonda Boguzaite, Ernestas Brazys, Almira Ramanaviciene, Evaldas Ciplys, Mindaugas Juozapaitis, Rimantas Slibinskas, Mikhael Bechelany, Arunas Ramanavicius

Electrochim Acta

January 20, 2022

This study describes the application of a polypyrrole-based sensor for the determination of SARS-CoV-2-S spike glycoprotein. The SARS-CoV-2-S spike glycoprotein is a spike protein of the coronavirus SARS-CoV-2 that recently…

Computational Approach to Combat COVID-19 Infection: Emerging Tool for Accelerating Drug Research.

Written by Biswa Mohan Sahoo, Subrat Kumar Bhattamisra, Sarita Das, Abhishek Tiwari, Varsha Tiwari, Manish Kumar, Sunil Singh

Curr Drug Discov Technol

January 17, 2022

BACKGROUND: Drug discovery and development process is an expensive, complex, time-consuming and risky. There are different techniques involved in the drug development process which include random screening, computational approach, molecular…

Porous carbon materials derived from discarded COVID-19 masks via microwave solvothermal method for lithium‑sulfur batteries.

Written by Chao Yuwen, Bingguo Liu, Qian Rong

Sci Total Environ

January 10, 2022

With the spread of COVID-19, disposable medical masks (DMMs) have become a significant source of new hazardous solid waste. Their proper disposal is not only beneficial to the safety of…

In Situ Nanocoating on Porous Pyrolyzed Paper Enables Antibiofouling and Sensitive Electrochemical Analyses in Biological Fluids.

ACS Appl Mater Interfaces

Written by Caroline Y N Nicoliche, Aline M Pascon, Ítalo R S Bezerra

January 6, 2022

Electrochemical detection in complex biofluids is a long-standing challenge as electrode biofouling hampers its sensing performance and commercial translation. To overcome this drawback, pyrolyzed paper as porous electrode coupled with…

High throughput molecularly imprinted polymers based electrochemical nanosensors for point-of-care diagnostics of COVID-19.

Written by Ayushi Singhal, Arpana Parihar, Neeraj Kumar

Mater Lett

January 1, 2022

The importance of early diagnosis of infectious disease has been revealed well by the COVID-19 pandemic. The current methods for testing SARS-CoV-2 mainly utilize biorecognition elements. The process of production…

High throughput molecularly imprinted polymers based electrochemical nanosensors for point-of-care diagnostics of COVID-19.

Written by Ayushi Singhal, Arpana Parihar, Neeraj Kumar

Mater Lett

January 1, 2022

Rapid, multiplexed, and nucleic acid amplification-free detection of SARS-CoV-2 RNA using an electrochemical biosensor.

Written by Leila Kashefi-Kheyrabadi, Huynh Vu Nguyen, Anna Go

January 1, 2022

Considering the worldwide health crisis associated with highly contagious severe respiratory disease of COVID-19 outbreak, the development of multiplexed, simple and rapid diagnostic platforms to detect severe acute respiratory syndrome…

A Recent Update on Advanced Molecular Diagnostic Techniques for COVID-19 Pandemic: An Overview.

Written by Akanksha Roberts, Raghuraj Singh Chouhan, Deepshikha Shahdeo

Front Immunol

December 14, 2021

Coronavirus disease 2019 (COVID-19), which started out as an outbreak of pneumonia, has now turned into a pandemic due to its rapid transmission. Besides developing a vaccine, rapid, accurate, and…

New approach in SARS-CoV-2 surveillance using biosensor technology: a review.

Environ Sci Pollut Res Int

Written by Dina M El-Sherif, Mohamed Abouzid, Mohamed S Gaballah, Alhassan Ali Ahmed, Muhammad Adeel, Sheta M Sheta

October 23, 2021

Biosensors are analytical tools that transform the bio-signal into an observable response. Biosensors are effective for early detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection because they target…

Computational approach towards the design of artemisinin-thymoquinone hybrids against main protease of SARS-COV-2.

Written by Victor Moreira de Oliveira, Matheus Nunes da Rocha, Emanuel Paula Magalhães

Futur J Pharm Sci

September 6, 2021

Background: The sanitary emergency installed in the world, generated by the pandemic of COVID-19, instigates the search for scientific strategies to mitigate the damage caused by the disease to different…

High Affinity Dimeric Aptamers Enable Rapid Electrochemical Detection of Wild-Type and B.1.1.7 SARS-CoV-2 in Unprocessed Saliva.

Written by Zijie Zhang, Richa Pandey, Jiuxing Li

Angew Chem Int Ed Engl

We report a simple and rapid saliva-based SARS-CoV-2 antigen test that utilizes a newly developed dimeric DNA aptamer, denoted as DSA1N5, that specifically recognizes the spike proteins of the wildtype…

Bioelectrochemical platforms to study and detect emerging pathogens.

Written by Mary C Machado, Marjon Zamani, Susan Daniel, Ariel L Furst

MRS Bull

The ongoing SARS-CoV-2 pandemic has emphasized the importance of technologies to rapidly detect emerging pathogens and understand their interactions with hosts. Platforms based on the combination of biological recognition and…

A minireview on nanoparticle-based sensors for detection of coronaviruses.

Written by Elaheh Rahimpour, Farzaneh Lotfipour, Abolghasem Jouyban

Bioanalysis

Coronaviruses (CoVs) are a class of viruses that cause respiratory tract infections in birds and mammals. Severe acute respiratory syndrome and Middle East respiratory syndrome are pathogenic human viruses. The…

Bioelectrochemical platforms to study and detect emerging pathogens.

Written by Mary C Machado, Marjon Zamani, Susan Daniel

MRS Bull

Rapid Point-of-Care COVID-19 Diagnosis with a Gold-Nanoarchitecture-Assisted Laser-Scribed Graphene Biosensor.

Written by Tutku Beduk, Duygu Beduk, José Ilton de Oliveira Filho, Figen Zihnioglu, Candan Cicek, Ruchan Sertoz, Bilgin Arda, Tuncay Goksel, Kutsal Turhan, Khaled N Salama, Suna Timur

Anal Chem

June 22, 2021

The global pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus has revealed the urgent need for accurate, rapid, and affordable diagnostic tests for epidemic understanding and…

Point-of-Care Biosensor-Based Diagnosis of COVID-19 Holds Promise to Combat Current and Future Pandemics.

Written by Arpana Parihar, Pushpesh Ranjan, Sunil K Sanghi, Avanish K Srivastava, Raju Khan

ACS Appl Bio Mater

November 16, 2020

Efficient and rapid detection of viruses plays an extremely important role in disease prevention, diagnosis, and environmental monitoring. Early screening of viral infection among the population has the potential to…

Fundamentals of Biosensors and Detection Methods.

Written by Marília Barreiros Dos Santos, Laura Rodriguez-Lorenzo, Raquel Queirós, Begoña Espiña

Adv Exp Med Biol

Biosensors have a great impact on our society to enhance the life quality, playing an important role in the development of Point-of-Care (POC) technologies for rapid diagnostics, and monitoring of…

Fundamentals of Biosensors and Detection Methods.