RADx-rad / Diagnostics Portal

Written by Teresa H Evering, Kara W Chew, Mark J Giganti, Carlee Moser, Mauricio Pinilla, David Alain Wohl, Judith S Currier, Joseph J Eron, Arzhang Cyrus Javan, Rachel Bender Ignacio, David Margolis, Qing Zhu, Ji Ma, Lijie Zhong, Li Yan, Ulises D'Andrea Nores, Keila Hoover, Bharat Mocherla, Manish C Choudhary, Rinki Deo, Justin Ritz, William A Fischer, Courtney V Fletcher, Jonathan Z Li, Michael D Hughes, Davey Smith, Eric S Daar

Ann Intern Med

April 18, 2023

BACKGROUND: Development of safe and effective SARS-CoV-2 therapeutics is a high priority. Amubarvimab and romlusevimab are noncompeting anti-SARS-CoV-2 monoclonal antibodies with an extended half-life. OBJECTIVE: To assess the safety and…

1-O-Octadecyl-2-O-benzyl-sn-glyceryl-3-phospho-GS-441524 (V2043). Evaluation of Oral V2043 in a Mouse Model of SARS-CoV-2 Infection and Synthesis and Antiviral Evaluation of Additional Phospholipid Esters with Enhanced Anti-SARS-CoV-2 Activity.

Written by Aaron F Carlin, James R Beadle, Alex E Clark, Kendra L Gully, Fernando R Moreira, Ralph S Baric, Rachel L Graham, Nadejda Valiaeva, Sandra L Leibel, William Bray, Rachel E McMillan, Jonathan E Freshman, Aaron F Garretson, Rachael N McVicar, Tariq Rana, Xing-Quan Zhang, Joyce A Murphy, Robert T Schooley, Karl Y Hostetler

J Med Chem

April 11, 2023

Early antiviral treatments, including intravenous remdesivir (RDV), reduce hospitalization and severe disease caused by COVID-19. An orally bioavailable RDV analog may facilitate earlier treatment of non-hospitalized COVID-19 patients. Here we…

Safety and Efficacy of Combined Tixagevimab and Cilgavimab Administered Intramuscularly or Intravenously in Nonhospitalized Patients With COVID-19: 2 Randomized Clinical Trials.

Written by Rachel A Bender Ignacio, Kara W Chew, Carlee Moser, Judith S Currier, Joseph J Eron, Arzhang Cyrus Javan, Mark J Giganti, Evgenia Aga, Michael Gibbs, Hervé Tchouakam Kouekam, Eva Johnsson, Mark T Esser, Keila Hoover, Gene Neytman, Matthew Newell, Eric S Daar, William Fischer, Courtney V Fletcher, Jonathan Z Li, Alexander L Greninger, Robert W Coombs, Michael D Hughes, Davey Smith, David Alain Wohl

JAMA Netw Open

April 3, 2023

IMPORTANCE: Development of effective, scalable therapeutics for SARS-CoV-2 is a priority. OBJECTIVE: To test the efficacy of combined tixagevimab and cilgavimab monoclonal antibodies for early COVID-19 treatment. DESIGN, SETTING, AND…

Perceived COVID-19 risk and testing experiences in the San Ysidro U.S./Mexico border region.

Written by Linda Salgin, Lawrence O Ayers, Maria-Linda Burola, Anne-Marie Engler, Alexis Osuna, Luis Gay, Kelli Cain, Nicole Stadnick, Borsika Rabin, Ilya Zaslavsky, Louise C Laurent, Robert Tukey, Marva Seifert

Transl Behav Med

March 31, 2023

Racial and ethnic disparities in COVID-19 incidence are pronounced in underserved U.S./Mexico border communities. Working and living environments in these communities can lead to increased risk of COVID-19 infection and…

Neutralizing Antibody Responses After Severe Acute Respiratory Syndrome Coronavirus 2 BA.2 and BA.2.12.1 Infection Do Not Neutralize BA.4 and BA.5 and Can Be Blunted by Nirmatrelvir/Ritonavir Treatment.

Written by Aaron F Carlin, Alex E Clark, Aaron F Garretson, William Bray, Magali Porrachia, AsherLev T Santos, Tariq M Rana, Antoine Chaillon, Davey M Smith

March 21, 2023

The factors contributing to the rapid emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) BA.4 and BA.5 subvariants in populations that experienced recent surges of BA.2 and BA.2.12.1 infections…

Genomic surveillance reveals dynamic shifts in the connectivity of COVID-19 epidemics

Written by Nathaniel L Matteson, Gabriel W Hassler, Ezra Kurzban, Madison A Schwab, Sarah A Perkins, Karthik Gangavarapu, Joshua I Levy, Edyth Parker, David Pride, Abbas Hakim, Peter De Hoff, Willi Cheung, Anelizze Castro-Martinez, Andrea Rivera, Anthony Veder, Ariana Rivera, Cassandra Wauer, Jacqueline Holmes, Jedediah Wilson, Shayla N Ngo, Ashley Plascencia, Elijah S Lawrence, Elizabeth W Smoot, Emily R Eisner, Rebecca Tsai, Marisol Chacon, Nathan A Baer, Phoebe Seaver, Rodolfo A Salido, Stefan Aigner, Toan T Ngo, Tom Barber, Tyler Ostrander, Rebecca Fielding-Miller, Elizabeth H Simmons, Oscar E Zazueta, Idanya Serafin-Higuera, Manuel Sanchez-Alavez, Jose L Moreno-Camacho, Abraham Garcia-Gil, Ashleigh R Murphy Schafer, Eric McDonald, Jeremy Corrigan, John D Malone, Sarah Stous, Seema Shah, Niema Moshiri, Alana Weiss, Catelyn Anderson, Christine M Aceves, Emily G Spencer, Emory C Hufbauer, Justin J Lee, Karthik S Ramesh, Kelly N Nguyen, Kieran Saucedo, Refugio Robles-Sikisaka, Kathleen M Fisch, Steven L Gonias, Amanda Birmingham, Daniel McDonald, Smruthi Karthikeyan, Natasha K Martin, Robert T Schooley, Agustin J Negrete, Horacio J Reyna, Jose R Chavez, Maria L Garcia, Jose M Cornejo-Bravo, David Becker, Magnus Isaksson, Nicole L Washington, William Lee, Richard S Garfein, Marco A Luna-Ruiz Esparza, Jonathan Alcantar-Fernandez, Benjamin Henson, Kristen Jepsen, Beatriz Olivares-Flores, Gisela Barrera-Badillo, Irma Lopez-Martinez, Jose E Ramirez-Gonzalez, Rita Flores-Leon, Stephen F Kingsmore, Alison Sanders, Allorah Pradenas, Benjamin White, Gary Matthews, Matt Hale, Ronald W McLawhon, Sharon L Reed, Terri Winbush, Ian H McHardy, Russel A Fielding, Laura Nicholson, Michael M Quigley, Aaron Harding, Art Mendoza, Omid Bakhtar, Sara H Browne, Jocelyn Olivas Flores, Diana G Rincon Rodriguez, Martin Gonzalez Ibarra, Luis C Robles Ibarra, Betsy J Arellano Vera, Jonathan Gonzalez Garcia, Alicia Harvey-Vera, Rob Knight, Louise C Laurent, Gene W Yeo, Joel O Wertheim, Xiang Ji, Michael Worobey, Marc A Suchard, Kristian G Andersen, Abraham Campos-Romero, Shirlee Wohl, Mark Zeller

March 19, 2023

The maturation of genomic surveillance in the past decade has enabled tracking of the emergence and spread of epidemics at an unprecedented level. During the COVID-19 pandemic, for example, genomic…

PF-D-Trimer, a protective SARS-CoV-2 subunit vaccine: immunogenicity and application.

Written by Zhihao Zhang, Jinhu Zhou, Peng Ni, Bing Hu, Normand Jolicoeur, Shuang Deng, Qian Xiao, Qian He, Gai Li, Yan Xia, Mei Liu, Cong Wang, Zhizheng Fang, Nan Xia, Zhe-Rui Zhang, Bo Zhang, Kun Cai, Yan Xu, Binlei Liu

NPJ Vaccines

March 15, 2023

The COVID-19 pandemic, caused by the SARS-CoV-2 virus, has had and continues to have a significant impact on global public health. One of the characteristics of SARS-CoV-2 is a surface…

Characterization of SARS-CoV-2 Distribution and Microbial Succession in a Clinical Microbiology Testing Facility during the SARS-CoV-2 Pandemic.

Written by Govind Prasad Sah, Grace Kovalick, Jessica Chopyk, Peiting Kuo, Lina Huang, Pooja Ghatbale, Promi Das, Susan Realegeno, Rob Knight, Jack A Gilbert, David T Pride

March 14, 2023

The exchange of microbes between humans and the built environment is a dynamic process that has significant impact on health. Most studies exploring the microbiome of the built environment have…

Blockchain-Enabled Immutable, Distributed, and Highly Available Clinical Research Activity Logging System for Federated COVID-19 Data Analysis from Multiple Institutions.

Written by Tsung-Ting Kuo, Anh Pham, Maxim E Edelson, Jihoon Kim, Jason Chan, Yash Gupta, Lucila Ohno-Machado

March 14, 2023

OBJECTIVE: We aimed to develop a distributed, immutable, and highly available cross-cloud blockchain system to facilitate federated data analysis activities among multiple institutions. MATERIALS AND METHODS: We pre-processed 9,166 COVID-19…

Cancer, more than a "COVID-19 co-morbidity".

Written by Chinmay T Jani, Robert T Schooley, Rana R Mckay, Scott M Lippman

Front Oncol

March 13, 2023

Patients with cancer represent a particularly vulnerable population at risk of adverse outcomes related to COVID-19. Collectively, the initial studies, including patients with and without cancer, confirmed that patients with…

Human microglial models to study host-virus interactions.

Written by Rachel E McMillan, Ellen Wang, Aaron F Carlin, Nicole G Coufal

Exp Neurol

March 11, 2023

Microglia, the resident macrophage of the central nervous system, are increasingly recognized as contributing to diverse aspects of human development, health, and disease. In recent years, numerous studies in both…

Analysis of a Broad Range of Carbonyl Metabolites in Exhaled Breath by UHPLC-MS

article-journal

Analytical Chemistry

Written by Zhenzhen Xie, James D. Morris, Stephanie J. Mattingly, Saurin R. Sutaria, Jiapeng Huang, Michael H. Nantz, Xiao-An Fu

February 23, 2023

Symptom and Viral Rebound in Untreated SARS-CoV-2 Infection.

Written by Rinki Deo, Manish C Choudhary, Carlee Moser, Justin Ritz, Eric S Daar, David A Wohl, Alexander L Greninger, Joseph J Eron, Judith S Currier, Michael D Hughes, Davey M Smith, Kara W Chew, Jonathan Z Li

Ann Intern Med

February 21, 2023

BACKGROUND: Although symptom and viral rebound have been reported after nirmatrelvir-ritonavir treatment, the trajectories of symptoms and viral load during the natural course of COVID-19 have not been well described.…

Identification of global inhibitors of cellular glycosylation.

Written by Daniel Madriz Sørensen, Christian Büll, Thomas D Madsen, Erandi Lira-Navarrete, Thomas Mandel Clausen, Alex E Clark, Aaron F Garretson, Richard Karlsson, Johan F A Pijnenborg, Xin Yin, Rebecca L Miller, Sumit K Chanda, Thomas J Boltje, Katrine T Schjoldager, Sergey Y Vakhrushev, Adnan Halim, Jeffrey D Esko, Aaron F Carlin, Ramon Hurtado-Guerrero, Roberto Weigert, Henrik Clausen, Yoshiki Narimatsu

February 20, 2023

Small molecule inhibitors of glycosylation enzymes are valuable tools for dissecting glycan functions and potential drug candidates. Screening for inhibitors of glycosyltransferases are mainly performed by in vitro enzyme assays…

Broadly neutralizing anti-S2 antibodies protect against all three human betacoronaviruses that cause deadly disease.

Written by Panpan Zhou, Ge Song, Hejun Liu, Meng Yuan, Wan-Ting He, Nathan Beutler, Xueyong Zhu, Longping V Tse, David R Martinez, Alexandra Schäfer, Fabio Anzanello, Peter Yong, Linghang Peng, Katharina Dueker, Rami Musharrafieh, Sean Callaghan, Tazio Capozzola, Oliver Limbo, Mara Parren, Elijah Garcia, Stephen A Rawlings, Davey M Smith, David Nemazee, Joseph G Jardine, Yana Safonova, Bryan Briney, Thomas F Rogers, Ian A Wilson, Ralph S Baric, Lisa E Gralinski, Dennis R Burton, Raiees Andrabi

Immunity

February 16, 2023

Pan-betacoronavirus neutralizing antibodies may hold the key to developing broadly protective vaccines against novel pandemic coronaviruses and to more effectively respond to SARS-CoV-2 variants. The emergence of Omicron and subvariants…

Protease-Responsive Potential-Tunable AIEgens for Cell Selective Imaging of TMPRSS2 and Accurate Inhibitor Screening.

Written by Yong Cheng, Alex E Clark, Wonjun Yim, Raina M Borum, Yu-Ci Chang, Zhicheng Jin, Tengyu He, Aaron F Carlin, Jesse V Jokerst

Anal Chem

February 8, 2023

Transmembrane protease serine 2 (TMPRSS2) is a plasma membrane protease that activates both spike protein of coronaviruses for cell entry and oncogenic signaling pathways for tumor progression. TMPRSS2 inhibition can…

Qualitative interviews to evaluate content validity of the ACTIV-2 COVID-19 Symptom Diary (ACSD).

Written by Louis S Matza, Katie D Stewart, April N Naegeli, Kayla M Mills, Karin S Coyne, Kara W Chew, Michael D Hughes, Davey M Smith

J Patient Rep Outcomes

January 31, 2023

BACKGROUND: Patient-reported outcome measures are needed to assess the impact of treatments for COVID-19 on symptoms. The ACTIV-2 COVID-19 Symptom Diary (ACSD) is being used in the ongoing Accelerating COVID-19…

PCIF1-mediated deposition of 5'-cap N

Written by Lingling Wang, Shaobo Wang, Lujing Wu, Wanyu Li, William Bray, Alex E Clark, Gwendolyn Michelle Gonzalez, Yinsheng Wang, Aaron F Carlin, Tariq M Rana

Proc Natl Acad Sci U S A

January 31, 2023

Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to be a major health problem worldwide. Due to the fast emergence of SARS-CoV-2 variants, understanding the molecular mechanisms of…

Public mental health during and after the SARS-CoV-2 pandemic: Opportunities for intervention via emotional self-efficacy and resilience.

Written by Melissa M Karnaze, Brent M Kious, Lindsay Z Feuerman, Sarah Classen, Jill O Robinson, Cinnamon S Bloss, Amy L McGuire

Front Psychol

January 23, 2023

IMPORTANCE: During the pandemic, the number of United States adults reporting clinically significant symptoms of anxiety and depression sky-rocketed, up from 11% in 2020 to more than 40% in 2021.…

Predictors of COVID-19 vaccine uptake among people who inject drugs.

Written by Steffanie A Strathdee, Daniela Abramovitz, Carlos F Vera, Irina Artamonova, Thomas L Patterson, Davey M Smith, Antoine Chaillon, Angela R Bazzi

Vaccine

January 23, 2023

INTRODUCTION: We studied characteristics of COVID-19 vaccination uptake among people who inject drugs (PWID). METHODS: Participants aged ≥18 years who injected drugs ≤1 month ago were recruited into a community-based…

Phase 2 safety and antiviral activity of SAB-185, a novel polyclonal antibody therapy for non-hospitalized adults with COVID-19.

Written by Babafemi O Taiwo, Kara W Chew, Carlee Moser, David Alain Wohl, Eric S Daar, Jonathan Z Li, Alexander L Greninger, Christoph Bausch, Thomas Luke, Keila Hoover, Gene Neytman, Mark J Giganti, Maxine Olefsky, Arzhang Cyrus Javan, Courtney V Fletcher, Joseph J Eron, Judith S Currier, Michael D Hughes, Davey M Smith

J Infect Dis

January 20, 2023

BACKGROUND: SAB-185, a novel fully-human IgG polyclonal immunoglobulin product, underwent phase 2 evaluation for non-hospitalized adults with mild-moderate COVID-19. METHODS: Participants received intravenous SAB-185 3,840 units/kg (low-dose) or placebo, or…

Publisher Correction: Antiviral and clinical activity of bamlanivimab in a randomized trial of non-hospitalized adults with COVID-19.

Published Erratum

Written by Kara W Chew, Carlee Moser, Eric S Daar, David A Wohl, Jonathan Z Li, Robert W Coombs, Justin Ritz, Mark Giganti, Arzhang Cyrus Javan, Yijia Li, Manish C Choudhary, Rinki Deo, Carlos Malvestutto, Paul Klekotka, Karen Price, Ajay Nirula, William Fischer, Veenu Bala, Ruy M Ribeiro, Alan S Perelson, Courtney V Fletcher, Joseph J Eron, Judith S Currier, Michael D Hughes, Davey M Smith

January 19, 2023

Hydroxychloroquine for treatment of non-hospitalized adults with COVID-19: A meta-analysis of individual participant data of randomized trials.

Written by Oriol Mitjà, Gilmar Reis, David R Boulware, Adam M Spivak, Ammar Sarwar, Christine Johnston, Brandon Webb, Michael D Hill, Davey Smith, Peter Kremsner, Marla Curran, David Carter, Jim Alexander, Marc Corbacho, Todd C Lee, Katherine Huppler Hullsiek, Emily G McDonald, Rachel Hess, Michael Hughes, Jared M Baeten, Ilan Schwartz, Luanne Metz, Lawrence Richer, Kara W Chew, Eric Daar, David Wohl, Michael Dunne

Clin Transl Sci

January 4, 2023

Hydroxychloroquine (HCQ) was initially promoted as an oral therapy for early treatment of coronavirus disease 2019 (COVID-19). Conventional meta-analyses cannot fully address the heterogeneity of different designs and outcomes of…

Antiretroviral Drugs for Treatment and Prevention of HIV Infection in Adults: 2022 Recommendations of the International Antiviral Society-USA Panel.

Written by Rajesh T Gandhi, Roger Bedimo, Jennifer F Hoy, Raphael J Landovitz, Davey M Smith, Ellen F Eaton, Clara Lehmann, Sandra A Springer, Paul E Sax, Melanie A Thompson, Constance A Benson, Susan P Buchbinder, Carlos Del Rio, Joseph J Eron, Huldrych F Günthard, Jean-Michel Molina, Donna M Jacobsen, Michael S Saag

JAMA

January 3, 2023

IMPORTANCE: Recent advances in treatment and prevention of HIV warrant updated recommendations to guide optimal practice. OBJECTIVE: Based on a critical evaluation of new data, to provide clinicians with recommendations…

Cocirculation and replacement of SARS-CoV-2 variants in crowded settings and marginalized populations along the US-Mexico border.

Written by Antoine Chaillon, Ietza Bojorquez, Jaime Sepúlveda, Alicia Yolanda Harvey-Vera, M Gudelia Rangel, Britt Skaathun, Sanjay R Mehta, Caroline Ignacio, Magali Porrachia, Davey M Smith, Steffanie A Strathdee

Salud Publica Mex

January 2, 2023

OBJECTIVE: To interrogate the circulating SARS-CoV-2 lin-eages and recombinant variants in persons living in migrant shelters and persons who inject drugs (PWID). MATERIALS AND METHODS: We combined data from two…

Use of platelet‐rich plasma for COVID‐19–related olfactory loss: a randomized controlled trial

article-journal

International Forum of Allergy & Rhinology

Written by Carol H. Yan, Sophie S. Jang, Hung‐Fu C. Lin, Yifei Ma, Ashoke R. Khanwalkar, Anthony Thai, Zara M. Patel

December 21, 2022

In Vitro Diagnostic Assay to Detect SARS-CoV-2-Neutralizing Antibody in Patient Sera Using Engineered ACE-2 Mini-Protein.

Written by Bruna Andersen Pereira de Jesus, Anderson Albino Gomes, Alex E Clark, Tayse Andrade Rodrigues, Melissa Ledgerwood-Lee, Westley Van Zant, Howard Brickner, Meiqiao Wang, David L Blum, Maria B Cassera, Aaron F Carlin, Eliah S Aronoff-Spencer, Gustavo Felippe da Silva, Maria de Lourdes Borba Magalhães, Partha Ray

December 18, 2022

The recent development and mass administration of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) vaccines allowed for disease control, reducing hospitalizations and mortality. Most of these vaccines target the SARS-CoV-2…

Human antibody BD-218 has broad neutralizing activity against concerning variants of SARS-CoV-2.

Written by Bo Wang, Hua Xu, Zi-Teng Liang, Tian-Ning Zhao, Xin Zhang, Tian-Bo Peng, You-Chun Wang, Xiao-Dong Su

Int J Biol Macromol

December 14, 2022

As SARS-CoV-2 variants of concern (VOC) reduce the effectiveness of existing anti-COVID therapeutics, it is increasingly critical to identify highly potent neutralizing antibodies (nAbs) that bind to conserved regions across…

Predominant SARS-CoV-2 variant impacts accuracy when screening for infection using exhaled breath vapor

article-journal

Communications Medicine

Written by Mitchell M. McCartney, Eva Borras, Dante E. Rojas, Tristan L. Hicks, Katherine L. Hamera, Nam K. Tran, Tina Tham, Maya M. Juarez, Enrique Lopez, Nicholas J. Kenyon, Cristina E. Davis

December 8, 2022

Leveraging an established neighbourhood-level, open access wastewater monitoring network to address public health priorities: a population-based study.

Written by Devin A Bowes, Erin M Driver, Simona Kraberger, Rafaela S Fontenele, LaRinda A Holland, Jillian Wright, Bridger Johnston, Sonja Savic, Melanie Engstrom Newell, Sangeet Adhikari, Rahul Kumar, Hanah Goetz, Allison Binsfeld, Kaxandra Nessi, Payton Watkins, Akhil Mahant, Jacob Zevitz, Stephanie Deitrick, Philip Brown, Richard Dalton, Chris Garcia, Rosa Inchausti, Wydale Holmes, Xiao-Jun Tian, Arvind Varsani, Efrem S Lim, Matthew Scotch, Rolf U Halden

Lancet Microbe

December 6, 2022

BACKGROUND: Before the COVID-19 pandemic, the US opioid epidemic triggered a collaborative municipal and academic effort in Tempe, Arizona, which resulted in the world's first open access dashboard featuring neighbourhood-level…

The Impact of the COVID-19 Pandemic on the Food Security of UK Adults Aged 20-65 Years (COVID-19 Food Security and Dietary Assessment Study).

Written by Michelle Thomas, Elizabeth Eveleigh, Zeynep Vural, Peter Rose, Amanda Avery, Lisa Coneyworth, Simon Welham

Nutrients

November 29, 2022

The first UK lockdown greatly impacted the food security status of UK adults. This study set out to establish if food procurement was adapted differently for different income groups and…

Bamlanivimab therapy for acute COVID-19 does not blunt SARS-CoV-2-specific memory T cell responses.

Written by Sydney I Ramirez, Alba Grifoni, Daniela Weiskopf, Urvi M Parikh, Amy Heaps, Farhoud Faraji, Scott F Sieg, Justin Ritz, Carlee B Moser, Joseph J Eron, Judith S Currier, Paul Klekotka, Alessandro Sette, David A Wohl, Eric S Daar, Michael D Hughes, Kara W Chew, Davey M Smith, Shane Crotty

JCI Insight

November 15, 2022

Despite the widespread use of SARS-CoV-2-specific monoclonal antibody (mAb) therapy for the treatment of acute COVID-19, the impact of this therapy on the development of SARS-CoV-2-specific T cell responses has…

Sentiment Analysis of Insomnia-Related Tweets via Combination of Transformers Using Dempster-Shafer Theory: A Pre-Peri COVID-19 Pandemic Retrospective Study.

Written by Arash Maghsoudi, Sara Nowakowski, Ritwick Agrawal, Amir Sharafkhaneh, Mark E Kunik, Aanand D Naik, Hua Xu, Javad Razjouyan

J Med Internet Res

November 15, 2022

BACKGROUND: The COVID-19 pandemic has imposed additional stress on population health that may result in a change of sleeping behavior. OBJECTIVE: In this study, we hypothesized that using natural language…

Predictors of SARS-CoV-2 RNA From Nasopharyngeal Swabs and Concordance With Other Compartments in Nonhospitalized Adults With Mild to Moderate COVID-19.

Written by Carlee Moser, Jonathan Z Li, Joseph J Eron, Evgenia Aga, Eric S Daar, David A Wohl, Robert W Coombs, Arzhang Cyrus Javan, Rachel A Bender Ignacio, Prasanna Jagannathan, Justin Ritz, Scott F Sieg, Urvi M Parikh, Michael D Hughes, Judith S Currier, Davey M Smith, Kara W Chew

November 11, 2022

BACKGROUND: Identifying characteristics associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA shedding may be useful to understand viral compartmentalization, disease pathogenesis, and risks for viral transmission. METHODS: Participants…

Defining Key Performance Indicators for the California COVID-19 Exposure Notification System (CA Notify).

Written by Eliah Aronoff-Spencer, Camille Nebeker, Alexander T Wenzel, Kevin Nguyen, Rachel Kunowski, Mingjia Zhu, Gary Adamos, Ravi Goyal, Sepideh Mazrouee, Aaron Reyes, Nicole May, Holly Howard, Christopher A Longhurst, Mohsen Malekinejad

Public Health Rep

October 31, 2022

OBJECTIVES: Toward common methods for system monitoring and evaluation, we proposed a key performance indicator framework and discussed lessons learned while implementing a statewide exposure notification (EN) system in California…

Emergence of SARS-CoV-2 escape mutations during Bamlanivimab therapy in a phase II randomized clinical trial.

Randomized Controlled Trial

Nat Microbiol

Written by Manish C Choudhary, Kara W Chew, Rinki Deo, James P Flynn, James Regan, Charles R Crain, Carlee Moser, Michael D Hughes, Justin Ritz, Ruy M Ribeiro, Ruian Ke, Joan A Dragavon, Arzhang Cyrus Javan, Ajay Nirula, Paul Klekotka, Alexander L Greninger, Courtney V Fletcher, Eric S Daar, David A Wohl, Joseph J Eron, Judith S Currier, Urvi M Parikh, Scott F Sieg, Alan S Perelson, Robert W Coombs, Davey M Smith, Jonathan Z Li

October 26, 2022

SARS-CoV-2 mutations that cause resistance to monoclonal antibody (mAb) therapy have been reported. However, it remains unclear whether in vivo emergence of SARS-CoV-2 resistance mutations alters viral replication dynamics or…

Nasal and Plasma SARS-CoV-2 RNA Levels are Associated with Timing of Symptom Resolution in the ACTIV-2 Trial of Non-hospitalized Adults with COVID-19.

Written by Yijia Li, Linda J Harrison, Kara W Chew, Judy S Currier, David A Wohl, Eric S Daar, Teresa H Evering, Ryan Wu, Mark Giganti, Justin Ritz, Arzhang Cyrus Javan, Robert Coombs, Carlee Moser, Michael D Hughes, Joseph J Eron, Davey M Smith, Jonathan Z Li

October 10, 2022

Acute COVID-19 symptoms limit daily activities, but little is known about its association with SARS-CoV-2 viral burden. In this exploratory analysis of placebo recipients in the ACTIV-2/A5401 platform trial, we…

Recurrence of Symptoms Following a 2-Day Symptom Free Period in Patients With COVID-19.

Written by Davey M Smith, Jonathan Z Li, Carlee Moser, Eunice Yeh, Judith S Currier, Kara W Chew, Michael D Hughes

JAMA Netw Open

October 3, 2022

Concordance of SARS-CoV-2 Antibody Results during a Period of Low Prevalence.

Written by Cheryl N Miller, Keri N Althoff, David J Schlueter, Hoda Anton-Culver, Qingxia Chen, Shawn Garbett, Francis Ratsimbazafy, Isaac Thomsen, Elizabeth W Karlson, Mine Cicek, Ligia A Pinto, Bradley A Malin, Lucila Ohno-Machado, Carolyn Williams, David Goldstein, Aymone Kouame, Andrea Ramirez, Kelly A Gebo, Sheri D Schully

mSphere

September 29, 2022

Accurate, highly specific immunoassays for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are needed to evaluate seroprevalence. This study investigated the concordance of results across four immunoassays targeting different antigens…

A single-administration therapeutic interfering particle reduces SARS-CoV-2 viral shedding and pathogenesis in hamsters.

Written by Sonali Chaturvedi, Nathan Beutler, Gustavo Vasen, Michael Pablo, Xinyue Chen, Giuliana Calia, Lauren Buie, Robert Rodick, Davey Smith, Thomas Rogers, Leor S Weinberger

Proc Natl Acad Sci U S A

September 27, 2022

The high transmissibility of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a primary driver of the COVID-19 pandemic. While existing interventions prevent severe disease, they exhibit mixed efficacy in…

PF-D-Trimer, a broadly protective SARS-CoV-2 subunit vaccine: immunogenicity and application

Written by Zhihao Zhang, Jinhu Zhou, Peng Ni, Bing Hu, Shuang Deng, Qian Xiao, Qian He, Gai Li, Yan Xia, Mei Liu, Cong Wang, Zhizheng Fang, Nan Xia, Zhe-Rui Zhang, Bo Zhang, Kun Cai, Normand Jolicoeur, Yan Xu, Binlei Liu

September 26, 2022

The COVID-19 pandemic, caused by the SARS-CoV-2 virus, has had and still has a considerable impact on global public health. One of the characteristics of SARS-CoV-2 is a surface homotrimeric…

Seroprevalence of influenza viruses in Shandong, Northern China during the COVID-19 pandemic.

Written by Chuansong Quan, Zhenjie Zhang, Guoyong Ding, Fengwei Sun, Hengxia Zhao, Qinghua Liu, Chuanmin Ma, Jing Wang, Liang Wang, Wenbo Zhao, Jinjie He, Yu Wang, Qian He, Michael J Carr, Dayan Wang, Qiang Xiao, Weifeng Shi

Front Med

September 24, 2022

Nonpharmaceutical interventions (NPIs) have been commonly deployed to prevent and control the spread of the coronavirus disease 2019 (COVID-19), resulting in a worldwide decline in influenza prevalence. However, the influenza…

Antiviral and clinical activity of bamlanivimab in a randomized trial of non-hospitalized adults with COVID-19.

August 22, 2022

Anti-SARS-CoV-2 monoclonal antibodies are mainstay COVID-19 therapeutics. Safety, antiviral, and clinical efficacy of bamlanivimab were evaluated in the randomized controlled trial ACTIV-2/A5401. Non-hospitalized adults were randomized 1:1 within 10 days…

A Self-Immolative Fluorescent Probe for Selective Detection of SARS-CoV-2 Main Protease.

Written by Ming Xu, Jiajing Zhou, Yong Cheng, Zhicheng Jin, Alex E Clark, Tengyu He, Wonjun Yim, Yi Li, Yu-Ci Chang, Zhuohong Wu, Pavla Fajtová, Anthony J O'Donoghue, Aaron F Carlin, Michael D Todd, Jesse V Jokerst

Anal Chem

August 16, 2022

Existing tools to detect and visualize severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) suffer from low selectivity, poor cell permeability, and high cytotoxicity. Here we report a novel self-immolative fluorescent…

A single-administration therapeutic interfering particle reduces SARS-CoV-2 viral shedding and pathogenesis in hamsters

Written by Sonali Chaturvedi, Nathan Beutler, Michael Pablo, Gustavo Vasen, Xinyue Chen, Giuliana Calia, Lauren Buie, Robert Rodick, Davey Smith, Thomas Rogers, Leor Weinberger

August 11, 2022

The high transmissibility of SARS-CoV-2 is a primary driver of the COVID-19 pandemic. While existing interventions prevent severe disease, they exhibit mixed efficacy in preventing transmission, presumably due to their…

Broadly neutralizing antibodies to SARS-related viruses can be readily induced in rhesus macaques.

Written by Wan-Ting He, Meng Yuan, Sean Callaghan, Rami Musharrafieh, Ge Song, Murillo Silva, Nathan Beutler, Wen-Hsin Lee, Peter Yong, Jonathan L Torres, Mariane Melo, Panpan Zhou, Fangzhu Zhao, Xueyong Zhu, Linghang Peng, Deli Huang, Fabio Anzanello, James Ricketts, Mara Parren, Elijah Garcia, Melissa Ferguson, William Rinaldi, Stephen A Rawlings, David Nemazee, Davey M Smith, Bryan Briney, Yana Safonova, Thomas F Rogers, Jennifer M Dan, Zeli Zhang, Daniela Weiskopf, Alessandro Sette, Shane Crotty, Darrell J Irvine, Andrew B Ward, Ian A Wilson, Dennis R Burton, Raiees Andrabi

Sci Transl Med

August 10, 2022

To prepare for future coronavirus (CoV) pandemics, it is desirable to generate vaccines capable of eliciting broadly neutralizing antibody responses to CoVs. Here, we show that immunization of macaques with…

Conformational flexibility in neutralization of SARS-CoV-2 by naturally elicited anti-SARS-CoV-2 antibodies.

Written by Ruofan Li, Michael Mor, Bingting Ma, Alex E Clark, Joel Alter, Michal Werbner, Jamie Casey Lee, Sandra L Leibel, Aaron F Carlin, Moshe Dessau, Meital Gal-Tanamy, Ben A Croker, Ye Xiang, Natalia T Freund

Commun Biol

August 5, 2022

As new variants of SARS-CoV-2 continue to emerge, it is important to assess the cross-neutralizing capabilities of antibodies naturally elicited during wild type SARS-CoV-2 infection. In the present study, we…

Urtica dioica Agglutinin: A plant protein candidate for inhibition of SARS-COV-2 receptor-binding domain for control of Covid19 Infection.

Written by Fatemeh Sabzian-Molaei, Mohammad Ali Nasiri Khalili, Mohammad Sabzian-Molaei, Hosein Shahsavarani, Alireza Fattah Pour, Ahmad Molaei Rad, Amin Hadi

July 28, 2022

Despite using effective drugs and vaccines for Covid 19, due to some limitations of current strategies and the high rate of coronavirus mutation, the development of medicines with effective inhibitory…

Combined Diagnosis of SARS-CoV-2: Rapid Antigen Detection as an Adjunct to Nucleic Acid Detection.

Written by Xuewen Li, Yiting Wang, Junqi Pan, Jiancheng Xu, Qi Zhou

Lab Med

July 27, 2022

Coronavirus disease 2019 is a serious threat to human life, and early diagnosis and screening can help control the COVID-19 pandemic. The high sensitivity of reverse transcriptase-polymerase chain reaction (RT-PCR)…

Protease-Responsive Peptide-Conjugated Mitochondrial-Targeting AIEgens for Selective Imaging and Inhibition of SARS-CoV-2-Infected Cells.

Written by Yong Cheng, Alex E Clark, Jiajing Zhou, Tengyu He, Yi Li, Raina M Borum, Matthew N Creyer, Ming Xu, Zhicheng Jin, Jingcheng Zhou, Wonjun Yim, Zhuohong Wu, Pavla Fajtová, Anthony J O'Donoghue, Aaron F Carlin, Jesse V Jokerst

ACS Nano

July 25, 2022

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a serious threat to human health and lacks an effective treatment. There is an urgent need for both real-time tracking and precise…

Association of compassion and empathy with prosocial health behaviors and attitudes in a pandemic.

Written by Melissa M Karnaze, John Bellettiere, Cinnamon S Bloss

July 22, 2022

This investigation examined how dispositional compassion and empathy were associated with prosocial behaviors and attitudes in the SARS-CoV-2 pandemic. Every two weeks from March 22 to June 15, 2020, we…

Structure-selected RBM immunogens prime polyclonal memory responses that neutralize SARS-CoV-2 variants of concern.

Written by Gonzalo Almanza, Alex E Clark, Valentina Kouznetsova, Eduardo Olmedillas, Andrea Castro, Igor F Tsigelny, Yan Wu, George F Gao, Sandra L Leibel, William Bray, Erica Ollmann Saphire, Aaron F Carlin, Maurizio Zanetti

PLoS Pathog

July 21, 2022

Successful control of the COVID-19 pandemic depends on vaccines that prevent transmission. The full-length Spike protein is highly immunogenic but the majority of antibodies do not target the virus: ACE2…

Performance of Two Commercial Assays for the Detection of Serum Aspergillus Galactomannan in Non-Neutropenic Patients.

Written by Rodrigo Almeida-Paes, Marcos de Abreu Almeida, Priscila Marques de Macedo, Diego H Caceres, Rosely Maria Zancopé-Oliveira

J Fungi (Basel)

July 18, 2022

Besides the relevance of aspergillosis in neutropenic patients, this mycosis has gained significance among non-neutropenic patients in last years. The detection of Aspergillus galactomannan has been used for aspergillosis diagnosis…

Self-reported adaptability among postgraduate dental learners and their instructors: Accelerated change induced by COVID-19.

Written by Farah Otaki, Fatemeh Amir-Rad, Manal Al-Halabi, Zaid Baqain, Nabil Zary

July 14, 2022

It is forecasted that the skills and competencies necessary for post-pandemic success in higher education need to be founded upon adaptability, coping, and Self- Regulated Learning (SRL). It is worth…

Comparative Dynamics of Delta and Omicron SARS-CoV-2 Variants across and between California and Mexico.

Written by Sanjay R Mehta, Davey M Smith, Celia Boukadida, Antoine Chaillon

July 8, 2022

Evolutionary analysis using viral sequence data can elucidate the epidemiology of transmission. Using publicly available SARS-CoV-2 sequence and epidemiological data, we developed discrete phylogeographic models to interrogate the emergence and…

Comparative pharmacokinetics of tixagevimab/cilgavimab (AZD7442) administered intravenously versus intramuscularly in symptomatic SARS-CoV-2 infection.

Written by Rachel A Bender Ignacio, David A Wohl, Rosalin Arends, Venkatesh Pilla Reddy, Ying Mu, Arzhang Cyrus Javan, Michael D Hughes, Joseph J Eron, Judith S Currier, Davey Smith, Kara W Chew, Michael Gibbs, Courtney V Fletcher

Clin Pharmacol Ther

July 7, 2022

AZD7442 is a combination of two human anti-SARS-CoV-2 monoclonal antibodies (mAbs), tixagevimab (AZD8895) and cilgavimab (AZD1061). Route of administration is an important consideration to improve treatment access. We assessed pharmacokinetics…

Wastewater sequencing reveals early cryptic SARS-CoV-2 variant transmission.

Written by Smruthi Karthikeyan, Joshua I Levy, Peter De Hoff, Greg Humphrey, Amanda Birmingham, Kristen Jepsen, Sawyer Farmer, Helena M Tubb, Tommy Valles, Caitlin E Tribelhorn, Rebecca Tsai, Stefan Aigner, Shashank Sathe, Niema Moshiri, Benjamin Henson, Adam M Mark, Abbas Hakim, Nathan A Baer, Tom Barber, Pedro Belda-Ferre, Marisol Chacón, Willi Cheung, Evelyn S Cresini, Emily R Eisner, Alma L Lastrella, Elijah S Lawrence, Clarisse A Marotz, Toan T Ngo, Tyler Ostrander, Ashley Plascencia, Rodolfo A Salido, Phoebe Seaver, Elizabeth W Smoot, Daniel McDonald, Robert M Neuhard, Angela L Scioscia, Alysson M Satterlund, Elizabeth H Simmons, Dismas B Abelman, David Brenner, Judith C Bruner, Anne Buckley, Michael Ellison, Jeffrey Gattas, Steven L Gonias, Matt Hale, Faith Hawkins, Lydia Ikeda, Hemlata Jhaveri, Ted Johnson, Vince Kellen, Brendan Kremer, Gary Matthews, Ronald W McLawhon, Pierre Ouillet, Daniel Park, Allorah Pradenas, Sharon Reed, Lindsay Riggs, Alison Sanders, Bradley Sollenberger, Angela Song, Benjamin White, Terri Winbush, Christine M Aceves, Catelyn Anderson, Karthik Gangavarapu, Emory Hufbauer, Ezra Kurzban, Justin Lee, Nathaniel L Matteson, Edyth Parker, Sarah A Perkins, Karthik S Ramesh, Refugio Robles-Sikisaka, Madison A Schwab, Emily Spencer, Shirlee Wohl, Laura Nicholson, Ian H Mchardy, David P Dimmock, Charlotte A Hobbs, Omid Bakhtar, Aaron Harding, Art Mendoza, Alexandre Bolze, David Becker, Elizabeth T Cirulli, Magnus Isaksson, Kelly M Schiabor Barrett, Nicole L Washington, John D Malone, Ashleigh Murphy Schafer, Nikos Gurfield, Sarah Stous, Rebecca Fielding-Miller, Richard S Garfein, Tommi Gaines, Cheryl Anderson, Natasha K Martin, Robert Schooley, Brett Austin, Duncan R MacCannell, Stephen F Kingsmore, William Lee, Seema Shah, Eric McDonald, Alexander T Yu, Mark Zeller, Kathleen M Fisch, Christopher Longhurst, Patty Maysent, David Pride, Pradeep K Khosla, Louise C Laurent, Gene W Yeo, Kristian G Andersen, Rob Knight

Nature

July 7, 2022

As SARS-CoV-2 continues to spread and evolve, detecting emerging variants early is critical for public health interventions. Inferring lineage prevalence by clinical testing is infeasible at scale, especially in areas…

Phenotypes of disease severity in a cohort of hospitalized COVID-19 patients: results from the IMPACC study

Written by - IMPACC group, Al Ozonoff, Joanna Schaenman, Naresh Doni Jayavelu, Carly E. Milliren, Carolyn S. Calfee, Charles B. Cairns, Monica Kraft, Lindsey R. Baden, Albert C. Shaw, Florian Krammer, Harm Van Bakel, Denise Esserman, Shanshan Liu, Ana Fernandez Sesma, Viviana Simon, David A. Hafler, Ruth R. Montgomery, Steven H. Kleinstein, Ofer Levy, Christian Bime, Elias K. Haddad, David J. Erle, Bali Pulendran, Kari C. Nadeau, Mark M. Davis, Catherine L. Hough, William B. Messer, Nelson I. Agudelo Higuita, Jordan P. Metcalf, Mark A. Atkinson, Scott C. Brakenridge, David B. Corry, Farrah Kheradmand, Lauren I. R. Ehrlich, Esther Melamed, Grace A. McComsey, Rafick Sekaly, Joann Diray-Arce, Bjoern Peters, Alison D. Augustine, Elaine F. Reed, Kerry McEnaney, Brenda Barton, Claudia Lentucci, Mehmet Saluvan, Ana C. Chang, Annmarie Hoch, Marisa Albert, Tanzia Shaheen, Alvin Kho, Sanya Thomas, Jing Chen, Maimouna D. Murphy, Mitchell Cooney, Scott Presnell, Leying Guan, Jeremy Gygi, Shrikant Pawar, Anderson Brito, Zain Khalil, James A. Overton, Randi Vita, Kerstin Westendorf, Cole Maguire, Slim Fourati, Ramin Salehi-Rad, Aleksandra Leligdowicz, Michael Matthay, Jonathan Singer, Kirsten N. Kangelaris, Carolyn M. Hendrickson, Matthew F. Krummel, Charles R. Langelier, Prescott G. Woodruff, Debra L. Powell, James N. Kim, Brent Simmons, I.Michael Goonewardene, Cecilia M. Smith, Mark Martens, Jarrod Mosier, Hiroki Kimura, Amy Sherman, Stephen Walsh, Nicolas Issa, Charles Dela Cruz, Shelli Farhadian, Akiko Iwasaki, Albert I. Ko, Evan J. Anderson, Aneesh Mehta, Jonathan E. Sevransky, Sharon Chinthrajah, Neera Ahuja, Angela Rogers, Maja Artandi, Sarah A.R. Siegel, Zhengchun Lu, Douglas A. Drevets, Brent R. Brown, Matthew L. Anderson, Faheem W. Guirgis, Rama V. Thyagarajan, Justin Rousseau, Dennis Wylie, Johanna Busch, Saurin Gandhi, Todd A. Triplett, George Yendewa, Olivia Giddings, Tatyana Vaysman, Bernard Khor, Adeeb Rahman, Daniel Stadlbauer, Jayeeta Dutta, Hui Xie, Seunghee Kim-Schulze, Ana Silvia Gonzalez-Reiche, Adriana van de Guchte, Holden T. Maecker, Keith Farrugia, Zenab Khan, Joanna Schaenman, Elaine F. Reed, Ramin Salehi-Rad, David Elashoff, Jenny Brook, Estefania Ramires-Sanchez, Megan Llamas, Adreanne Rivera, Claudia Perdomo, Dawn C. Ward, Clara E. Magyar, Jennifer Fulcher, Yumiko Abe-Jones, Saurabh Asthana, Alexander Beagle, Sharvari Bhide, Sidney A. Carrillo, Suzanna Chak, Rajani Ghale, Ana Gonzales, Alejandra Jauregui, Norman Jones, Tasha Lea, Deanna Lee, Raphael Lota, Jeff Milush, Viet Nguyen, Logan Pierce, Priya Prasad, Arjun Rao, Bushra Samad, Cole Shaw, Austin Sigman, Pratik Sinha, Alyssa Ward, Andrew - Willmore, Jenny Zhan, Sadeed Rashid, Nicklaus Rodriguez, Kevin Tang, Luz Torres Altamirano, Legna Betancourt, Cindy Curiel, Nicole Sutter, Maria Tercero Paz, Gayelan Tietje-Ulrich, Carolyn Leroux, Jennifer Connors, Mariana Bernui, Michele Kutzler, Carolyn Edwards, Edward Lee, Edward Lin, Brett Croen, Nicholas Semenza, Brandon Rogowski, Nataliya Melnyk, Kyra Woloszczuk, Gina Cusimano, Matthew Bell, Sara Furukawa, Renee McLin, Pamela Marrero, Julie Sheidy, George P. Tegos, Crystal Nagle, Nathan Mege, Kristen Ulring, Vicki Seyfert-Margolis, Michelle Conway, Dave Francisco, Allyson Molzahn, Heidi Erickson, Connie Cathleen Wilson, Ron Schunk, Trina Hughes, Bianca Sierra, Kinga K. Smolen, Michael Desjardins, Simon van Haren, Xhoi Mitre, Jessica Cauley, Xiofang Li, Alexandra Tong, Bethany Evans, Christina Montesano, Jose Humberto Licona, Jonathan Krauss, Jun Bai Park Chang, Natalie Izaguirre, Omkar Chaudhary, Andreas Coppi, John Fournier, Subhasis Mohanty, M. Catherine Muenker, Allison Nelson, Khadir Raddassi, Michael Rainone, William Ruff, Syim Salahuddin, Wade L. Schulz, Pavithra Vijayakumar, Haowei Wang, Elsio Wunder Jr., H. Patrick Young, Yujiao Zhao, Miti Saksena, Deena Altman, Erna Kojic, Komal Srivastava, Lily Q. Eaker, Maria Carolina Bermudez, Katherine F. Beach, Levy A. Sominsky, Arman Azad, Juan Manuel Carreno, Gagandeep Singh, Ariel Raskin, Johnstone Tcheou, Dominika Bielak, Hisaaki Kawabata, Lubbertus CF Mulder, Giulio Kleiner, Laurel Bristow, Laila Hussaini, Kieffer Hellmeister, Hady Samaha, Andrew Cheng, Christine Spainhour, Erin M. Scherer, Brandi Johnson, Amer Bechnak, Caroline R. Ciric, Lauren Hewitt, Bernadine Panganiban, Chistopher Huerta, Jacob Usher, Erin Carter, Nina Mcnair, Susan Pereira Ribeiro, Alexandra S. Lee, Evan Do, Andrea Fernandes, Monali Manohar, Thomas Hagan, Catherine Blish, Hena Naz Din, Jonasel Roque, Samuel S. Yang, Amanda E. Brunton, Peter E. Sullivan, Matthew Strnad, Zoe L. Lyski, Felicity J. Coulter, John L. Booth, Lauren A. Sinko, Lyle Moldawer, Brittany Borrensen, Brittney Roth-Manning, Li-Zhen Song, Ebony Nelson, Megan Lewis-Smith, Jacob Smith, Pablo Guaman Tipan, Nadia Siles, Sam Bazzi, Janelle Geltman, Kerin Hurley, Giovanni Gabriele, Scott Sieg, Matthew C. Altman, Patrice M. Becker, Nadine Rouphael

July 5, 2022

BackgroundBetter understanding of the association between characteristics of patients hospitalized with coronavirus disease 2019 (COVID-19) and outcome is needed to further improve upon patient management.

MethodsImmunophenotyping Assessment in a COVID-19…

Social support coping styles and psychological distress during the COVID-19 pandemic: The moderating role of sex.

Written by Caitlin L McLean, Gage M Chu, Melissa M Karnaze, Cinnamon S Bloss, Ariel J Lang

J Affect Disord

July 1, 2022

BACKGROUND: The coronavirus disease 2019 (COVID-19) pandemic led to the onset and exacerbation of mental health problems, such as stress, anxiety, and depression; yet stay-at-home-orders affected individuals' ability to make…

Using the multiphase optimization strategy (MOST) framework to optimize an intervention to increase COVID-19 testing for Black and Latino/Hispanic frontline essential workers: A study protocol.

Written by Marya Gwadz, Charles M Cleland, Maria Lizardo, Robert L Hawkins, Greg Bangser, Lalitha Parameswaran, Victoria Stanhope, Jennifer A Robinson, Shristi Karim, Tierra Hollaway, Paola G Ramirez, Prema L Filippone, Amanda S Ritchie, Angela Banfield, Elizabeth Silverman

BMC Public Health

June 21, 2022

BACKGROUND: Among those at highest risk for COVID-19 exposure is the large population of frontline essential workers in occupations such food service, retail, personal care, and in-home health services, among…

Virologic and Immunologic Characterization of COVID-19 Recrudescence after Nirmatrelvir/Ritonavir Treatment.

Written by Aaron F Carlin, Alex E Clark, Antoine Chaillon, Aaron F Garretson, William Bray, Magali Porrachia, AsherLev T Santos, Tariq M Rana, Davey M Smith

June 20, 2022

We isolated a SARS-CoV-2 BA.2 variant from a person with COVID-19 recrudescence after nirmatrelvir/ritonavir treatment. Antiviral sensitivity and neutralizing antibody testing were performed with both parental SARS-CoV-2 and multiple variants…

Monoclonal antibody treatment drives rapid culture conversion in SARS-CoV-2 infection.

Written by Julie Boucau, Kara W Chew, Manish C Choudhary, Rinki Deo, James Regan, James P Flynn, Charles R Crain, Michael D Hughes, Justin Ritz, Carlee Moser, Joan A Dragavon, Arzhang C Javan, Ajay Nirula, Paul Klekotka, Alexander L Greninger, Robert W Coombs, William A Fischer, Eric S Daar, David A Wohl, Joseph J Eron, Judith S Currier, Davey M Smith, Jonathan Z Li, Amy K Barczak

Cell Rep Med

June 20, 2022

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) monoclonal antibodies (mAbs) are among the treatments recommended for high-risk ambulatory persons with coronavirus 2019 (COVID-19). Here, we study viral culture dynamics post-treatment…

Comparison of RT-qPCR and Digital PCR Methods for Wastewater-Based Testing of SARS-CoV-2

Written by Adrian Hinkle, Hannah D Greenwald, Matthew Metzger, Melissa Thornton, Lauren C Kennedy, Kristin Loomis, Monica Herrera, Raymond-John Abayan, Kara L Nelson, Rose S Kantor

June 16, 2022

Wastewater-based epidemiology is an important tool for monitoring SARS-CoV-2 and other molecular targets in populations, using wastewater as a pooled sample. We compared the sensitivity, susceptibility to inhibition, and quantification…

Sentinel Cards Provide Practical SARS-CoV-2 Monitoring in School Settings.

Written by Victor J Cantú, Karenina Sanders, Pedro Belda-Ferre, Rodolfo A Salido, Rebecca Tsai, Brett Austin, William Jordan, Menka Asudani, Amanda Walster, Celestine G Magallanes, Holly Valentine, Araz Manjoonian, Carrissa Wijaya, Vinton Omaleki, Stefan Aigner, Nathan A Baer, Maryann Betty, Anelizze Castro-Martínez, Willi Cheung, Peter De Hoff, Emily Eisner, Abbas Hakim, Alma L Lastrella, Elijah S Lawrence, Toan T Ngo, Tyler Ostrander, Ashley Plascencia, Shashank Sathe, Elizabeth W Smoot, Aaron F Carlin, Gene W Yeo, Louise C Laurent, Anna Liza Manlutac, Rebecca Fielding-Miller, Rob Knight

June 15, 2022

A promising approach to help students safely return to in person learning is through the application of sentinel cards for accurate high resolution environmental monitoring of SARS-CoV-2 traces indoors. Because…

Implementation of Practical Surface SARS-CoV-2 Surveillance in School Settings.

Written by Victor J Cantú, Pedro Belda-Ferre, Rodolfo A Salido, Rebecca Tsai, Brett Austin, William Jordan, Menka Asudani, Amanda Walster, Celestine G Magallanes, Holly Valentine, Araz Manjoonian, Carrissa Wijaya, Vinton Omaleki, Karenina Sanders, Stefan Aigner, Nathan A Baer, Maryann Betty, Anelizze Castro-Martínez, Willi Cheung, Evelyn S Crescini, Peter De Hoff, Emily Eisner, Abbas Hakim, Bhavika Kapadia, Alma L Lastrella, Elijah S Lawrence, Toan T Ngo, Tyler Ostrander, Shashank Sathe, Phoebe Seaver, Elizabeth W Smoot, Aaron F Carlin, Gene W Yeo, Louise C Laurent, Anna Liza Manlutac, Rebecca Fielding-Miller, Rob Knight

June 15, 2022

Surface sampling for SARS-CoV-2 RNA detection has shown considerable promise to detect exposure of built environments to infected individuals shedding virus who would not otherwise be detected. Here, we compare…

A retrospective cohort study of the effect of SARS-CoV-2 point of care rapid RT-PCR at the Emergency Department on targeted admission.

Written by Susanne E Mortazavi, Malin Inghammar, Claus Christiansen, Anne-Katrine Pesola, Mikael Stenkilsson, Magnus Paulsson

BMC Infect Dis

June 13, 2022

BACKGROUND: To prevent nosocomial transmission of SARS-CoV-2, infection prevention control (IPC) measures are implemented for patients with symptoms compatible with COVID-19 until reliable test results are available. This delays admission…

Standardizing, Harmonizing, and Protecting Data Collection to Broaden the Impact of COVID-19 Research: The Rapid Acceleration of Diagnostics-Underserved Populations (RADx-up) Initiative.

Written by Gabriel A Carrillo, Michael Cohen-Wolkowiez, Emily M D'Agostino, Keith Marsolo, Lisa M Wruck, Laura Johnson, James Topping, Al Richmond, Giselle Corbie, Warren A Kibbe

June 9, 2022

OBJECTIVE: The Rapid Acceleration of Diagnostics-Underserved Populations (RADx-UP) program is a consortium of community-engaged research projects with the goal of increasing access to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)…

Targeted isolation of diverse human protective broadly neutralizing antibodies against SARS-like viruses.

Written by Wan-Ting He, Rami Musharrafieh, Ge Song, Katharina Dueker, Longping V Tse, David R Martinez, Alexandra Schäfer, Sean Callaghan, Peter Yong, Nathan Beutler, Jonathan L Torres, Reid M Volk, Panpan Zhou, Meng Yuan, Hejun Liu, Fabio Anzanello, Tazio Capozzola, Mara Parren, Elijah Garcia, Stephen A Rawlings, Davey M Smith, Ian A Wilson, Yana Safonova, Andrew B Ward, Thomas F Rogers, Ralph S Baric, Lisa E Gralinski, Dennis R Burton, Raiees Andrabi

Nat Immunol

June 2, 2022

The emergence of current severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOCs) and potential future spillovers of SARS-like coronaviruses into humans pose a major threat to human…

COVID-19 pneumonia chest radiographic severity score: variability assessment among experienced and in-training radiologists and creation of a multireader composite score database for artificial intelligence algorithm development.

Written by Marly van Assen, Mohammadreza Zandehshahvar, Hossein Maleki, Yashar Kiarashi, Timothy Arleo, Arthur E Stillman, Peter Filev, Amir H Davarpanah, Eugene A Berkowitz, Stefan Tigges, Scott J Lee, Brianna L Vey, Ali Adibi, Carlo N De Cecco

Br J Radiol

June 1, 2022

OBJECTIVE: The purpose was to evaluate reader variability between experienced and in-training radiologists of COVID-19 pneumonia severity on chest radiograph (CXR), and to create a multireader database suitable for AI…

COVID-19-induced silent myocarditis and newly developed hypertension in a 3-year-old boy.

Written by Elaheh Malakan Rad, Sara Momtazmanesh

Egypt Heart J

May 31, 2022

BACKGROUND: COVID-19 myocarditis occurs in 7-28% of patients admitted in the hospital with or without multisystem inflammatory syndrome. It may present as fulminant myocarditis. Dilated cardiomyopathy as a sequela of…

Proceedings of the Clinical Microbiology Open 2018 and 2019 - a Discussion about Emerging Trends, Challenges, and the Future of Clinical Microbiology.

Written by Christopher D Doern, Melissa B Miller, Kevin Alby, Michael A Bachman, Stephen M Brecher, Aida Casiano-Colon, Marc Roger Couturier, J Kristie Johnson, James E Kirby, Erin McElvania, Duane W Newton, Frederick S Nolte, Preeti Pancholi, Peggy McNult, Vaishali Dharmarha, Sherry Dunbar

J Clin Microbiol

May 31, 2022

Clinical Microbiology Open (CMO), a meeting supported by the American Society for Microbiology's Clinical and Public Health Microbiology Committee (CPHMC) and Corporate Council, provides a unique interactive platform for leaders…

Deep mutational scanning identifies SARS-CoV-2 Nucleocapsid escape mutations of currently available rapid antigen tests

Written by Filipp Frank, Meredith Marie Keen, Anuradha Rao, Leda Bassit, Xu Liu, Heather Brittany Bowers, Anamika B Patel, Michael L Cato, Julie A Sullivan, Morgan Greenleaf, Anne Piantadosi, Wilbur Lam, William Hudson, Eric A. Ortlund

May 20, 2022

Widespread and frequent testing is critical to prevent the spread of COVID-19, and rapid antigen tests are the diagnostic tool of choice in many settings. With new viral variants continuously…

Evaluation of Neutralizing Antibodies against SARS-CoV-2 Variants after Infection and Vaccination Using a Multiplexed Surrogate Virus Neutralization Test.

Written by Kara L Lynch, Shuxia Zhou, Ravi Kaul, Roger Walker, Alan H Wu

Clin Chem

May 18, 2022

BACKGROUND: The SARS-CoV-2 virus has mutated and evolved since the inception of the COVID-19 pandemic bringing into question the future effectiveness of current vaccines and antibody therapeutics. With evolution of…

Pivoting Novel Exosome-Based Technologies for the Detection of SARS-CoV-2.

Written by Christine Happel, Chariz Peñalber-Johnstone, Danilo A Tagle

May 18, 2022

The National Institutes of Health (NIH) launched the Rapid Acceleration of Diagnostics (RADx) initiative to meet the needs for COVID-19 diagnostic and surveillance testing, and to speed its innovation in…

SARS-CoV-2 Seroconversion in an Adult Horse with Direct Contact to a COVID-19 Individual.

Written by Nicola Pusterla, Antoine Chaillon, Caroline Ignacio, Davey M Smith, Samantha Barnum, Kaila O Y Lawton, Greg Smith, Bradley Pickering

May 14, 2022

The authors report on a possible direct exposure to SARS-CoV-2 from a COVID-19-positive individual to an adult horse. The individual, diagnosed with COVID-19 (Delta B.1.617.2), had daily contact to her…

Factors Associated With COVID-19 Death in the United States: Cohort Study.

JMIR Public Health Surveill

Written by Uan-I Chen, Hua Xu, Trudy Millard Krause, Raymond Greenberg, Xiao Dong, Xiaoqian Jiang

May 12, 2022

BACKGROUND: Since the initial COVID-19 cases were identified in the United States in February 2020, the United States has experienced a high incidence of the disease. Understanding the risk factors…

Antigen Detection Tests for SARS-CoV-2: a systematic review and meta-analysis on real world data.

Written by Matteo Riccò, Silvia Ranzieri, Simona Peruzzi, Marina Valente, Federico Marchesi, Nicola Luigi Bragazzi, Davide Donelli, Federica Balzarini, Pietro Ferraro, Vincenza Gianfredi, Carlo Signorelli

Acta Biomed

May 11, 2022

Background and aim Rapid antigen detection (RAD) tests on nasopharyngeal specimens have been recently made available for SARS-CoV-2 infections, and early studies suggested their potential utilization as rapid screening and…

Recurrent neural network models (CovRNN) for predicting outcomes of patients with COVID-19 on admission to hospital: model development and validation using electronic health record data.

Written by Laila Rasmy, Masayuki Nigo, Bijun Sai Kannadath, Ziqian Xie, Bingyu Mao, Khush Patel, Yujia Zhou, Wanheng Zhang, Angela Ross, Hua Xu, Degui Zhi

Lancet Digit Health

April 21, 2022

BACKGROUND: Predicting outcomes of patients with COVID-19 at an early stage is crucial for optimised clinical care and resource management, especially during a pandemic. Although multiple machine learning models have…

CoRad-19 - Modular Digital Teaching during the SARS-CoV-2 Pandemic.

Written by Andreas Stefan Brendlin, Isabel Molwitz, Thekla Helene Oechtering, Jörg Barkhausen, Alex Frydrychowicz, Tanja Sulkowski, Maren Friederike Balks, Michael Buchholz, Stefan Lohwasser, Martin Völker, Olaf Goldschmidt, Anja Johenning, Sabine Schlender, Christian Paulus, Gerald Antoch, Sabine Dettmer, Bettina Baeßler, David Maintz, Daniel Pinto Dos Santos, Thomas J Vogl, Elke Hattingen, Dietrich Stoevesandt, Sebastian Reinartz, Corinna Storz, Katharina Müller-Peltzer, Fabian Bamberg, Fabian Rengier, Meike Weis, Anne Frisch, Nienke Lynn Hansen, Manuel Kolb, Michael Maurer, Konstantin Nikolaou, Saif Afat, Ahmed E Othman

Rofo

April 19, 2022

PURPOSE: During the SARS-CoV-2 pandemic, higher education worldwide had to switch to digital formats. The purpose of this study was to evaluate CoRad-19, a digital teaching tool created by the…

Combining human and machine intelligence for clinical trial eligibility querying.

Written by Yilu Fang, Betina Idnay, Yingcheng Sun, Hao Liu, Zhehuan Chen, Karen Marder, Hua Xu, Rebecca Schnall, Chunhua Weng

April 15, 2022

OBJECTIVE: To combine machine efficiency and human intelligence for converting complex clinical trial eligibility criteria text into cohort queries. MATERIALS AND METHODS: Criteria2Query (C2Q) 2.0 was developed to enable real-time…

Role of serology tests in COVID-19 non-hospitalized patients: A cross-sectional study.

Written by Mohammad Taghi Haghi Ashtiani, Parisa Sadeghi Rad, Kosar Asnaashari, Alireza Shahhosseini, Fatemeh Berenji, Setareh Mamishi

April 14, 2022

INTRODUCTION: Severe acute respiratory syndrome coronavirus (SARS-CoV2) has imposed catastrophic impressions on the world. After all the focused researches conducted in the COVID-19 area, many features remain obscure. We have…

Delivery of Cancer Care in Ontario, Canada, During the First Year of the COVID-19 Pandemic.

Written by Meghan J Walker, Jonathan Wang, Joshua Mazuryk, Siew-Mei Skinner, Olivia Meggetto, Eta Ashu, Steven Habbous, Narges Nazeri Rad, Gabriela Espino-Hernández, Ryan Wood, Munaza Chaudhry, Saba Vahid, Julia Gao, Daniela Gallo-Hershberg, Eric Gutierrez, Claudia Zanchetta, Deanna Langer, Victoria Zwicker, Michelle Rey, Martin C Tammemägi, Jill Tinmouth, Rachel Kupets, Anna M Chiarelli, Simron Singh, Padraig Warde, Leta Forbes, Julian Dobranowski, Jonathan Irish, Linda Rabeneck

JAMA Netw Open

April 1, 2022

Importance: The COVID-19 pandemic has impacted cancer systems worldwide. Quantifying the changes is critical to informing the delivery of care while the pandemic continues, as well as for system recovery…

Factors associated with severity of COVID-19 disease in a multicenter cohort of people with HIV in the United States, March-December 2020.

J Acquir Immune Defic Syndr

Written by Adrienne E Shapiro, Rachel A Bender Ignacio, Bridget M Whitney, Joseph A Delaney, Robin M Nance, Laura Bamford, Darcy Wooten, Jeanne C Keruly, Greer Burkholder, Sonia Napravnik, Kenneth H Mayer, Allison R Webel, H Nina Kim, Stephen E Van Rompaey, Katerina Christopoulos, Jeffrey Jacobson, Maile Karris, Davey Smith, Mallory O Johnson, Amanda Willig, Joseph J Eron, Peter Hunt, Richard D Moore, Michael S Saag, W Christopher Mathews, Heidi M Crane, Edward R Cachay, Mari M Kitahata

April 1, 2022

BACKGROUND: Understanding the spectrum of COVID-19 in people with HIV (PWH) is critical to provide clinical guidance and risk-reduction strategies. SETTING: CNICS, a U.S. multisite clinical cohort of PWH in…

A biomedical open knowledge network harnesses the power of AI to understand deep human biology.

Written by Sergio E Baranzini, Katy Börner, John Morris, Charlotte A Nelson, Karthik Soman, Erica Schleimer, Michael Keiser, Mark Musen, Roger Pearce, Tahsin Reza, Brett Smith, Bruce W Herr, Boris Oskotsky, Angela Rizk-Jackson, Katherine P Rankin, Stephan J Sanders, Riley Bove, Peter W Rose, Sharat Israni, Sui Huang

AI Mag

March 31, 2022

Knowledge representation and reasoning (KR&R) has been successfully implemented in many fields to enable computers to solve complex problems with AI methods. However, its application to biomedicine has been lagging…

A human antibody reveals a conserved site on beta-coronavirus spike proteins and confers protection against SARS-CoV-2 infection.

Written by Panpan Zhou, Meng Yuan, Ge Song, Nathan Beutler, Namir Shaabani, Deli Huang, Wan-Ting He, Xueyong Zhu, Sean Callaghan, Peter Yong, Fabio Anzanello, Linghang Peng, James Ricketts, Mara Parren, Elijah Garcia, Stephen A Rawlings, Davey M Smith, David Nemazee, John R Teijaro, Thomas F Rogers, Ian A Wilson, Dennis R Burton, Raiees Andrabi

Sci Transl Med

March 23, 2022

Broadly neutralizing antibodies (bnAbs) to coronaviruses (CoVs) are valuable in their own right as prophylactic and therapeutic reagents to treat diverse CoVs and as templates for rational pan-CoV vaccine design.…

Immune and Clotting Dysfunction Detected in Saliva and Blood Plasma after COVID-19.

Written by Hyesun Jang, Saibyasachi Choudhury, Yanbao Yu, Benjamin L. Sievers, Terri Gelbart, Harinder Singh, Stephen A. Rawlings, Amy Proal, Gene S. Tan, Davey Smith, Marcelo Freire

March 21, 2022

A growing number of studies indicate that coronavirus disease 2019 (COVID-19) is associated with inflammatory sequelae, but molecular signatures governing the normal vs. pathologic convalescence process have not been well-delineated.…

COVID-19 Prediction using Genomic Footprint of SARS-CoV-2 in Air, Surface Swab and Wastewater Samples

Preprints

Written by Helena M Solo-Gabriele, Shelja Kumar, Samantha Abelson, Johnathon Penso, Julio Contreras, Kristina M Babler, Mark E Sharkey, Alejandro M A Mantero, Walter E Lamar, John J Tallon, Erin Kobetz, Natasha Schaefer Solle, Bhavarth S Shukla, Richard J Kenney, Christopher E Mason, Stephan C Schürer, Dusica Vidovic, Sion L Williams, George S Grills, Dushyantha T Jayaweera, Mehdi Mirsaeidi, Naresh Kumar

March 17, 2022

Key points: Question: Could environmental surveillance provide a means of early detection for SARS-CoV-2 in high population communities, such as college campuses, or even cities?Findings:In this surveillance study, SARS-CoV-2 was…

Biomarkers Selection for Population Normalization in SARS-CoV-2 Wastewater-based Epidemiology

Preprints

Written by Shu-Yu Hsu, Mohamed B Bayati, Chenhui Li, Hsin-Yeh Hsieh, Anthony Belenchia, Jessica Klutts, Sally A Zemmer, Melissa Reynolds, Elizabeth Semkiw, Hwei-Yiing Johnson, Trevor Foley, Chris G Wieberg, Jeff Wenzel, Marc C Johnson, Chung-Ho Lin

March 15, 2022

Wastewater-based epidemiology (WBE) has been one of the most cost-effective approaches to track the SARS-CoV-2 levels in the communities since the COVID-19 outbreak in 2020. Normalizing SARS-CoV-2 concentrations by the…

Development of a T cell-based immunodiagnostic system to effectively distinguish SARS-CoV-2 infection and COVID-19 vaccination status.

Written by Esther Dawen Yu, Eric Wang, Emily Garrigan, Benjamin Goodwin, Aaron Sutherland, Alison Tarke, James Chang, Rosa Isela Gálvez, Jose Mateus, Sydney I Ramirez, Stephen A Rawlings, Davey M Smith, Gilberto Filaci, April Frazier, Daniela Weiskopf, Jennifer M Dan, Shane Crotty, Alba Grifoni, Alessandro Sette, Ricardo da Silva Antunes

Cell Host Microbe

March 9, 2022

Both SARS-CoV-2 infections and COVID-19 vaccines elicit memory T cell responses. Here, we report the development of 2 pools of experimentally defined SARS-CoV-2 T cell epitopes that, in combination with…

Antibodies to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in All of Us Research Program Participants, 2 January to 18 March 2020.

Written by Keri N Althoff, David J Schlueter, Hoda Anton-Culver, James Cherry, Joshua C Denny, Isaac Thomsen, Elizabeth W Karlson, Fiona P Havers, Mine S Cicek, Stephen N Thibodeau, Ligia A Pinto, Douglas Lowy, Bradley A Malin, Lucila Ohno-Machado, Carolyn Williams, David Goldstein, Aymone Kouame, Andrea Ramirez, Adrienne Roman, Norman E Sharpless, Kelly A Gebo, Sheri D Schully

March 1, 2022

BACKGROUND: With limited severe acute respiratory syndrome coronavirus (SARS-CoV-2) testing capacity in the United States at the start of the epidemic (January-March 2020), testing was focused on symptomatic patients with…

Discovery and Mechanism of SARS-CoV-2 Main Protease Inhibitors.

Written by Sarah Huff, Indrasena Reddy Kummetha, Shashi Kant Tiwari, Matthew B Huante, Alex E Clark, Shaobo Wang, William Bray, Davey Smith, Aaron F Carlin, Mark Endsley, Tariq M Rana

J Med Chem

February 24, 2022

The emergence of a new coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), presents an urgent public health crisis. Without available targeted therapies, treatment options remain limited for COVID-19 patients.…

A Dual-Color Fluorescent Probe Allows Simultaneous Imaging of Main and Papain-like Proteases of SARS-CoV-2-Infected Cells for Accurate Detection and Rapid Inhibitor Screening.

Written by Yong Cheng, Raina M Borum, Alex E Clark, Zhicheng Jin, Colman Moore, Pavla Fajtová, Anthony J O'Donoghue, Aaron F Carlin, Jesse V Jokerst

Angew Chem Int Ed Engl

February 21, 2022

The main protease (Mpro ) and papain-like protease (PLpro ) play critical roles in SARS-CoV-2 replication and are promising targets for antiviral inhibitors. The simultaneous visualization of Mpro and PLpro…

SARS-CoV-2 Infections and Incidence at a North Carolina Pre-Kindergarten-12 School During In-Person Education: August 2020 to January 2021.

Written by Pavan V Thakkar, Kanecia O Zimmerman, Daniel K Benjamin, Ibukunoluwa C Kalu

J Sch Health

February 16, 2022

BACKGROUND: School closures were initially believed to mitigate SARS-CoV-2, but instead may have had a limited role in reducing community SARS-CoV-2 transmission. We describe a single school's experience with in-person…

Novel informatics approaches to COVID-19 Research: From methods to applications.

Editorial

J Biomed Inform

Written by Hua Xu, David L Buckeridge, Fei Wang, Peter Tarczy-Hornoch

February 16, 2022

Risk of new-onset type 2 diabetes in 600 055 people after COVID-19: A cohort study.

Written by Morgan Birabaharan, David C Kaelber, Jeremy H Pettus, Davey M Smith

Diabetes Obes Metab

February 15, 2022

Differential antibody production by symptomatology in SARS-CoV-2 convalescent individuals

Written by Sharada Saraf, Xianming Zhu, Ruchee Shrestha, Tania S. Bonny, Owen R. Baker, Evan J. Beck, Reinaldo E. Fernandez, Yolanda Eby, Olivia Akinde, Jessica E. Ruff, Patrizio Caturegli, Andrew D. Redd, Evan M. Bloch, Thomas C. Quinn, Aaron AR Tobian, Oliver Laeyendecker

February 10, 2022

The association between COVID-19 symptoms and antibody responses against SARS-CoV-2 is poorly characterized. We analyzed antibody levels in individuals with known SARS-CoV-2 infection to identify potential antibody-symptom associations. Convalescent plasma…

Engineering Defensin α-helix to produce high-affinity SARS-CoV-2 Spike protein binding ligands.

Written by Leonardo Antonio Fernandes, Anderson Albino Gomes, Maria de Lourdes Borba Magalhaes, Partha Ray, Gustavo Felippe da Silva

February 10, 2022

The binding of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Spike protein to the Angiotensin-Converting Enzyme 2 (ACE2) receptor expressed on the host cells is a critical initial step for…

Transmission of SARS-CoV-2: still up in the air - Authors' reply.

Written by Trisha Greenhalgh, Jose L Jimenez, Kimberly A Prather, Zeynep Tufeki, David Fisman, Robert Schooley

Lancet

February 5, 2022

The outcome of using intravenous immunoglobulin (IVIG) in critically ill COVID-19 patients': a retrospective, multi-centric cohort study.

Written by Mohammadreza Salehi, Mahdi Barkhori Mehni, Mohammadmehdi Akbarian, Samrand Fattah Ghazi, Nasim Khajavi Rad, Omid Moradi Moghaddam, SaeedReza Jamali Moghaddam, Masoumeh Hosseinzadeh Emam, Sayed Hamidreza Abtahi, Maryam Moradi, Fereshteh Ghiasvand

Eur J Med Res

February 3, 2022

BACKGROUND: During the COVID-19 pandemic, different treatments have been used in critically ill patients. Using intravenous immunoglobulin (IVIG) has been suggested in various studies as an effective option. Our study…

SARS-CoV-2 RNA in urban wastewater samples to monitor the COVID-19 pandemic in Lombardy, Italy (March-June 2020).

Written by Sara Castiglioni, Silvia Schiarea, Laura Pellegrinelli, Valeria Primache, Cristina Galli, Laura Bubba, Federica Mancinelli, Marilisa Marinelli, Danilo Cereda, Emanuela Ammoni, Elena Pariani, Ettore Zuccato, Sandro Binda

Sci Total Environ

February 1, 2022

Wastewater-based viral surveillance was proposed as a promising approach to monitor the circulation of SARS-CoV-2 in the general population. The aim of this study was to develop an analytical method…

An expanded high throughput RT-PCR assay to rapidly identify all known SARS-CoV-2 variants of concern using melting temperature coding.

Written by Padmapriya P Banada, Raquel Green, Sukalyani Banik, Deanna Streck, Ibsen Montalvan, Robert Reiss, Robert Jones, Salvatore Marras, Soumitesh Chakravorty, David Alland

January 21, 2022

BackgroundThe rapid emergence of new vaccine-resistant SARS-CoV-2 variants of concern (VOC) requires an equally rapid deployment of diagnostic tests to specifically identify each VOC as soon as it arises. Here,…

Assessing SARS-CoV-2 Neutralizing Antibodies after BNT162b2 Vaccination and Their Correlation with SARS-CoV-2 IgG Anti-S1, Anti-RBD and Anti-S2 Serological Titers.

Written by Angélica Ramos, Maria João Cardoso, Luís Ribeiro, João Tiago Guimarães

Diagnostics (Basel)

January 15, 2022

The humoral response through neutralizing antibodies (NAbs) is a key component of the immune response to COVID-19. However, the plaque reduction neutralization test (PRNT), the gold standard for determining NAbs,…

A cross-sectional study of gastrointestinal manifestations in COVID-19 Egyptian patients.

Written by Ahmed Abozaid Ahmed Teima, Amany Abas Amer, Lamiaa I Mohammed, Zeinab A Kasemy, Samar Ha Aloshari, Mohamed Meligy Ahmed, Ahmed Abuamer, Ahmed Shabaan, Hassan Ahmed Elzohry, Sayed F Abdelwahab, Heba Mohamed Abdallah, Sabry Moawad Abdelmageed, Mohamed A Sakr, Mohamed Abdel-Samiee

Ann Med Surg (Lond)

January 11, 2022

Background: The latest novel corona virus disease (COVID-19) pandemic shows a significant health concern. We aimed to study the prevalence of gastrointestinal symptoms among COVID-19 Egyptian patients. Methods: A cross-sectional…

Persistence of SARS CoV-2 S1 Protein in CD16+ Monocytes in Post-Acute Sequelae of COVID-19 (PASC) up to 15 Months Post-Infection.

Written by Bruce K Patterson, Edgar B Francisco, Ram Yogendra, Emily Long, Amruta Pise, Hallison Rodrigues, Eric Hall, Monica Herrera, Purvi Parikh, Jose Guevara-Coto, Timothy J Triche, Paul Scott, Saboor Hekmati, Dennis Maglinte, Xaiolan Chang, Rodrigo A Mora-Rodríguez, Javier Mora

Front Immunol

January 10, 2022

The recent COVID-19 pandemic is a treatment challenge in the acute infection stage but the recognition of chronic COVID-19 symptoms termed post-acute sequelae SARS-CoV-2 infection (PASC) may affect up to…

Treatment of Coronavirus Disease 2019-Evidence-based or Personalized Medicine?

Editorial

Written by Ferric C Fang, Robert T Schooley

January 7, 2022

Planning Considerations and Lessons Learned From a COVID-19 Mass Community Vaccination Center.

Written by Benjamin Fischl, Andrew T Patterson, Joseph Baxter, James Watson, Jesse Hemsworth, David Valentine, Jacob Wessler, Danny Wong

Mil Med

January 4, 2022

The emergency use authorization for multiple coronavirus disease 2019 (COVID-19) vaccines came at a pivotal time for the USA. In January 2021, the country exceeded 400,000 deaths from COVID-19. The…

A cohort study of the effect of SARS-CoV-2 point of care rapid RT-PCR at the Emergency Department on targeted admission

Written by Susanne E Mortazavi, Malin Inghammar, Claus Christansen

December 31, 2021

(ii)BackgroundTo prevent nosocomial transmission of SARS-CoV-2, infection control measures are implemented for patients with symptoms compatible with COVID-19 until reliable test results are available. This delay targeted admission to the…

Changes in hospitalizations for respiratory diseases following the COVID-19 epidemic.

Written by Kai-Ge Wang, Li Guo, Qian-Feng Xiao, Pan-Wen Tian, Dan Liu, Wei-Min Li

Chin Med J (Engl)

December 30, 2021

Wastewater sequencing uncovers early, cryptic SARS-CoV-2 variant transmission

Written by Smruthi Karthikeyan, Joshua I Levy, Peter De Hoff, Greg Humphrey, Amanda Birmingham, Kristen Jepsen, Sawyer Farmer, Helena M. Tubb, Tommy Valles, Caitlin E Tribelhorn, Rebecca Tsai, Stefan Aigner, Shashank Sathe, Niema Moshiri, Benjamin Henson, Abbas Hakim, Nathan A Baer, Tom Barber, Pedro Belda-Ferre, Marisol Chacon, Willi Cheung, Evelyn S Crescini, Emily R Eisner, Alma L Lastrella, Elijah S Lawrence, Clarisse A Marotz, Toan T Ngo, Tyler Ostrander, Ashley Plascencia, Rodolfo A Salido, Phoebe Seaver, Elizabeth W Smoot, Daniel McDonald, Robert M Neuhard, Angela L Scioscia, Alysson M. Satterlund, Elizabeth H Simmons, Dismas B. Abelman, David Brenner, Judith Carbone Bruner, Anne Buckley, Michael Ellison, Jeffrey Gattas, Steven L Gonias, Matt Hale, Faith Kirkham Hawkins, Lydia Ikeda, Hemlata Jhaveri, Ted Johnson, Vince Kellen, Brendan Kremer, Gary C. Matthews, Ronald McLawhon, Pierre Ouillet, Daniel Park, Allorah Pradenas, Sharon Reed, Lindsay Riggs, Alison M. Sanders, Bradley Sollenberger, Angela Song, Benjamin White, Terri Winbush, Christine M Aceves, Catelyn Anderson, Karthik Gangavarapu, Emory Hufbauer, Ezra Kurzban, Justin Lee, Nathaniel L Matteson, Edyth Parker, Sarah A Perkins, Karthik S Ramesh, Refugio Robles-Sikisaka, Madison A Schwab, Emily Spencer, Shirlee Wohl, Laura Nicholson, Ian H Mchardy, David P Dimmock, Charlotte A Hobbs, Omid Bakhtar, Aaron Harding, Art Mendoza, Alexandre Bolze, David Becker, Elizabeth T Cirulli, Magnus Isaksson, Kelly M Schiabor Barrett, Nicole L Washington, John D Malone, Ashleigh Murphy Schafer, Nikos Gurfield, Sarah Stous, Rebecca Fielding-Miller, Tommi Gaines, Richard Garfein, Cheryl A. M. Anderson, Natasha K. Martin, Robert T Schooley, Brett Austin, Duncan R. MacCannell, Stephen F Kingsmore, William Lee, Seema Shah, Eric McDonald, Alexander T. Yu, Mark Zeller, Kathleen M Fisch, Christopher A. Longhurst, Patty Maysent, David Pride, Pradeep K. Khosla, Louise C Laurent, Gene W Yeo, Kristian G Andersen, Rob Knight

December 27, 2021

Broad-Spectrum In Vitro Antiviral Activity of ODBG-P-RVn: An Orally-Available, Lipid-Modified Monophosphate Prodrug of Remdesivir Parent Nucleoside (GS-441524).

Written by Michael K Lo, Punya Shrivastava-Ranjan, Payel Chatterjee, Mike Flint, James R Beadle, Nadejda Valiaeva, Joyce Murphy, Robert T Schooley, Karl Y Hostetler, Joel M Montgomery, Christina F Spiropoulou

December 22, 2021

The necessity for intravenous administration of remdesivir confines its utility for treatment of coronavirus disease 2019 (COVID-19) to hospitalized patients. We evaluated the broad-spectrum antiviral activity of ODBG-P-RVn, an orally…

Lessons Learned: Beta-Testing the Digital Health Checklist for Researchers Prompts a Call to Action by Behavioral Scientists.

Written by Rebecca Bartlett Ellis, Julie Wright, Lisa Soederberg Miller, Danielle Jake-Schoffman, Eric B Hekler, Carly M Goldstein, Danielle Arigo, Camille Nebeker

J Med Internet Res

December 22, 2021

Digital technologies offer unique opportunities for health research. For example, Twitter posts can support public health surveillance to identify outbreaks (eg, influenza and COVID-19), and a wearable fitness tracker can…

Analysis of SARS-CoV-2 RNA Persistence across Indoor Surface Materials Reveals Best Practices for Environmental Monitoring Programs.

Written by Rodolfo A Salido, Victor J Cantú, Alex E Clark, Sandra L Leibel, Anahid Foroughishafiei, Anushka Saha, Abbas Hakim, Alhakam Nouri, Alma L Lastrella, Anelizze Castro-Martínez, Ashley Plascencia, Bhavika K Kapadia, Bing Xia, Christopher A Ruiz, Clarisse A Marotz, Daniel Maunder, Elijah S Lawrence, Elizabeth W Smoot, Emily Eisner, Evelyn S Crescini, Laura Kohn, Lizbeth Franco Vargas, Marisol Chacón, Maryann Betty, Michal Machnicki, Min Yi Wu, Nathan A Baer, Pedro Belda-Ferre, Peter De Hoff, Phoebe Seaver, R Tyler Ostrander, Rebecca Tsai, Shashank Sathe, Stefan Aigner, Sydney C Morgan, Toan T Ngo, Tom Barber, Willi Cheung, Aaron F Carlin, Gene W Yeo, Louise C Laurent, Rebecca Fielding-Miller, Rob Knight

December 21, 2021

Environmental monitoring in public spaces can be used to identify surfaces contaminated by persons with coronavirus disease 2019 (COVID-19) and inform appropriate infection mitigation responses. Research groups have reported detection…

Identification of a therapeutic interfering particle-A single-dose SARS-CoV-2 antiviral intervention with a high barrier to resistance.

Written by Sonali Chaturvedi, Gustavo Vasen, Michael Pablo, Xinyue Chen, Nathan Beutler, Arjun Kumar, Elizabeth Tanner, Sylvia Illouz, Donna Rahgoshay, John Burnett, Leo Holguin, Pei-Yi Chen, Blaise Ndjamen, Melanie Ott, Robert Rodick, Thomas Rogers, Davey M Smith, Leor S Weinberger

December 9, 2021

Viral-deletion mutants that conditionally replicate and inhibit the wild-type virus (i.e., defective interfering particles, DIPs) have long been proposed as single-administration interventions with high genetic barriers to resistance. However, theories…

Lessons learned from SARS-CoV-2 measurements in wastewater.

Written by Mark E Sharkey, Naresh Kumar, Alejandro M A Mantero, Kristina M Babler, Melinda M Boone, Yoslayma Cardentey, Elena M Cortizas, George S Grills, James Herrin, Jenny M Kemper, Richard Kenney, Erin Kobetz, Jennifer Laine, Walter E Lamar, Christopher C Mader, Christopher E Mason, Anda Z Quintero, Brian D Reding, Matthew A Roca, Krista Ryon, Natasha Schaefer Solle, Stephan C Schürer, Bhavarth Shukla, Mario Stevenson, Thomas Stone, John J Tallon, Sreeharsha S Venkatapuram, Dusica Vidovic, Sion L Williams, Benjamin Young, Helena M Solo-Gabriele

Sci Total Environ

December 1, 2021

Standardized protocols for wastewater-based surveillance (WBS) for the RNA of SARS-CoV-2, the virus responsible for the current COVID-19 pandemic, are being developed and refined worldwide for early detection of disease…

Cerebral Venous Sinus Thrombosis in a Patient With Mild Symptoms of COVID-19 Pneumonia.

Written by Asad Chohan, Farah Chohan, Pedram Rad

Cureus

November 25, 2021

Although coronavirus disease 2019 (COVID-19) infection is mainly associated with pneumonia, several non-respiratory complications may also occur. Cerebral venous sinus thrombosis (CVST) is a rare but potentially fatal complication of…

Do Words Matter? Detecting Social Isolation and Loneliness in Older Adults Using Natural Language Processing.

Written by Varsha D Badal, Camille Nebeker, Kaoru Shinkawa, Yasunori Yamada, Kelly E Rentscher, Ho-Cheol Kim, Ellen E Lee

Front Psychiatry

November 16, 2021

Introduction: Social isolation and loneliness (SI/L) are growing problems with serious health implications for older adults, especially in light of the COVID-19 pandemic. We examined transcripts from semi-structured interviews with…

Experience in fostering regional collaboration and Coordination to use data for battling infectious diseases in sub-Saharan Africa.

Written by Geoffrey Arunga, Tome Ca, Patricia Odero, Ahmed Bashir, Serge Manituo Somda, Fatuma Adan, Martin Weiss, Wayne Naidoo, Frank Adjei Benin, Todd Malone, Christopher A LeGrand, Andrew Yona Kitua

East Afr Health Res J

November 15, 2021

The emergence of COVID-19 highlights globalisation realties, where diseases may emerge from anywhere and rapidly spread globally. Lessons emphasise the necessity for strengthening regional and global collaboration and coordination to…

Cowpea Mosaic Virus Nanoparticle Vaccine Candidates Displaying Peptide Epitopes Can Neutralize the Severe Acute Respiratory Syndrome Coronavirus.

Written by Oscar A Ortega-Rivera, Sourabh Shukla, Matthew D Shin, Angela Chen, Veronique Beiss, Miguel A Moreno-Gonzalez, Yi Zheng, Alex E Clark, Aaron F Carlin, Jonathan K Pokorski, Nicole F Steinmetz

ACS Infect Dis

November 12, 2021

The development of vaccines against coronaviruses has focused on the spike (S) protein, which is required for the recognition of host-cell receptors and thus elicits neutralizing antibodies. Targeting conserved epitopes…

Prevention of Covid-19 with the BNT162b2 and mRNA-1273 Vaccines.

Written by Robert T Schooley

N Engl J Med

November 4, 2021

Outpatient Treatment of Severe Acute Respiratory Syndrome Coronavirus 2 Infection to Prevent Coronavirus Disease 2019 Progression.

Written by Myron S Cohen, David A Wohl, William A Fischer, Davey M Smith, Joseph J Eron

November 2, 2021

As of March 2021, coronavirus disease 2019 (COVID-19) had caused more than 123 million infections and almost 3 million deaths worldwide. Dramatic advances have been made in vaccine development and…

Evaluation of Severe Acute Respiratory Syndrome Coronavirus 2 Transmission Mitigation Strategies on a University Campus Using an Agent-Based Network Model.

Written by Ravi Goyal, John Hotchkiss, Robert T Schooley, Victor De Gruttola, Natasha K Martin

November 2, 2021

Universities are faced with decisions on how to resume campus activities while mitigating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) risk. To provide guidance for these decisions, we developed an…

Factors associated with the time to return negative RT-PCR from COVID-19 in paediatric patients: a retrospective cohort study.

Written by Jianbo Shao, Hong Xu, Zhixi Liu, Xiaohua Ying, Hua Xu, Xianfeng Wang, Jinmiao Lu, Yidie Huang, Guangfei Wang, Yanling He, Jie Chen, Shuli Ma, Shangrong Zou, Yuxia Cui, Ruijie Chen, Jin Lu, Xuyuan Li, Zhiping Li, Guoying Huang, Weibing Wang

BMJ Open

October 25, 2021

OBJECTIVE: This study aimed to describe the epidemiological and clinical features and potential factors related to the time to return negative reverse transcriptase (RT)-PCR in discharged paediatric patients with COVID-19.…

Factors associated with severity of COVID-19 disease in a multicenter cohort of people with HIV in the United States, March-December 2020

Written by Adrienne E Shapiro, Rachel A Bender Ignacio, Bridget M Whitney, Joseph CA Delaney, Robin M Nance, Laura Bamford, Darcy Wooten, Jeanne C Keruly, Greer Burkholder, Sonia Napravnik, Kenneth H Mayer, Allison R Webel, H Nina Kim, Stephen Van Rompaey, Katerina Christopoulos, Jeffrey Jacobson, Maile Karris, Davey Smith, Mallory O Johnson, Amanda Willig, Joseph J Eron, Peter Hunt, Richard D Moore, Michael S Saag, W Christopher Mathews, Heidi M Crane, Edward R Cachay, Mari M Kitahata

October 18, 2021

BackgroundUnderstanding the spectrum of SARS-CoV-2 infection and COVID-19 disease in people with HIV (PWH) is critical to provide clinical guidance and implement risk-reduction strategies.

ObjectiveTo characterize COVID-19 in PWH in…

Tele-Neurorehabilitation During the COVID-19 Pandemic: Implications for Practice in Low- and Middle-Income Countries.

Written by Abhishek Srivastava, Aishwarya Swaminathan, Manigandan Chockalingam, Murali K Srinivasan, Nirmal Surya, Partha Ray, Prasanna S Hegde, Preetie Shetty Akkunje, Sanjivani Kamble, Sonal Chitnis, Sureshkumar Kamalakannan, Suvarna Ganvir, Urvashi Shah

Front Neurol

October 5, 2021

The importance of neurorehabilitation services for people with disabilities is getting well-recognized in low- and middle-income countries (LMICs) recently. However, accessibility to the same has remained the most significant challenge,…

Resurgence of SARS-CoV-2 Infection in a Highly Vaccinated Health System Workforce.

Written by Jocelyn Keehner, Lucy E Horton, Nancy J Binkin, Louise C Laurent, David Pride, Christopher A Longhurst, Shira R Abeles, Francesca J Torriani

N Engl J Med

September 30, 2021

CovRNN - A recurrent neural network model for predicting outcomes of COVID-19 patients: model development and validation using EHR data

Written by Laila Rasmy, Masayuki Nigo, Bijun Sai Kannadath, Ziqian Xie, Bingyu Mao, Khush Patel, Yujia Zhou, Wanheng Zhang, Angela M. Ross, Hua Xu, Degui Zhi

September 29, 2021

BackgroundPredicting outcomes of COVID-19 patients at an early stage is critical for optimized clinical care and resource management, especially during a pandemic. Although multiple machine learning models have been proposed…

Work from home and musculoskeletal pain in telecommunications workers during COVID-19 pandemic: a pilot study.

Written by Azra Huršidić Radulović, Roko Žaja, Milan Milošević

Arh Hig Rada Toksikol

September 28, 2021

One of the side-effects of the COVID-19 pandemic is a global change in work ergonomic patterns as millions of people replaced their usual work environment with home to limit the…

An optimized stepwise algorithm combining rapid antigen and RT-qPCR for screening of COVID-19 patients.

Written by Philippe Halfon, Guillaume Penaranda, Hacène Khiri

September 23, 2021

BACKGROUND & AIM: We investigated the combination of rapid antigen detection (RAD) and RT-qPCR assays in a stepwise procedure to optimize the detection of COVID-19. METHODS: From August 2020 to…

Rethinking Remdesivir: Synthesis, Antiviral Activity, and Pharmacokinetics of Oral Lipid Prodrugs.

Antimicrob Agents Chemother

Written by Robert T Schooley, Aaron F Carlin, James R Beadle, Nadejda Valiaeva, Xing-Quan Zhang, Alex E Clark, Rachel E McMillan, Sandra L Leibel, Rachael N McVicar, Jialei Xie, Aaron F Garretson, Victoria I Smith, Joyce Murphy, Karl Y Hostetler

September 17, 2021

Remdesivir (RDV; GS-5734) is currently the only FDA-approved antiviral drug for the treatment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The drug is approved for use in adults…

Prevalence and Workplace Drivers of Burnout in Cancer Care Physicians in Ontario, Canada.

Written by Simron Singh, Ashley Farrelly, Catherine Chan, Brett Nicholls, Narges Nazeri-Rad, Daniela Bellicoso, Andrea Eisen, Conrad B Falkson, Colleen Fox, Claire Holloway, Erin Kennedy, Robin McLeod, David Rothenberger, Maureen Trudeau, Tait Shanafelt, Glenn Bauman

JCO Oncol Pract

September 10, 2021

PURPOSE: Provider well-being has become the fourth pillar of the quadruple aim for providing quality care. Exacerbated by the global COVID-19 pandemic, provider well-being has become a critical issue for…

Differential Antibody Response to mRNA COVID-19 Vaccines in Healthy Subjects.

Written by Sarah E Wheeler, Galina V Shurin, Mary Yost

Knowledge about development and duration of virus-specific antibodies after COVID-19 vaccination is important for understanding how to limit the pandemic via vaccination in different populations and societies. However, the clinical…

Comprehensive Characterization of COVID-19 Patients with Repeatedly Positive SARS-CoV-2 Tests Using a Large U.S. Electronic Health Record Database.

Written by Xiao Dong, Yujia Zhou, Xiao-Ou Shu, Elmer V Bernstam, Rebecca Stern, David M Aronoff, Hua Xu, Loren Lipworth

In the absence of genome sequencing, two positive molecular tests for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) separated by negative tests, prolonged time, and symptom resolution remain the best…

Molecular Mirror Technology Facilitates High-Throughput, Accurate SARS-CoV-2 Testing.

Written by Susan Realegeno, Sara Hash, Charlene Wong, Roland Liu, Jovan Shepherd, Robert T Schooley, David A Lipson, Frederick Fung, Suresh Menon, David T Pride

Tests to diagnose acute SARS-CoV-2 infection are at the center of controlling the COVID-19 pandemic. Rapid tests benefit from providing quick results but suffer from lower sensitivity, while PCR tests…

Structure-based analyses of neutralization antibodies interacting with naturally occurring SARS-CoV-2 RBD variants.

Written by Hua Xu, Bo Wang, Tian-Ning Zhao, Zi-Teng Liang, Tian-Bo Peng, Xiao-Hui Song, Jia-Jing Wu, You-Chun Wang, Xiao-Dong Su

Cell Res

Predictors of poor precautionary practices towards COVID-19 among cancer patients.

Written by Abdul R Jazieh, Assia A Bensalem, Adda Bounedjar

Future Oncol

September 2, 2021

Objective: Our study goal was to evaluate the behavioral response and practices of cancer patients to the coronavirus disease 2019 (COVID-19) pandemic in the Middle East and north Africa. Methods:…

Life or limb: an international qualitative study on decision making in sarcoma surgery during the COVID-19 pandemic.

Written by Samantha Bunzli, Penny O'Brien, Will Aston, Miguel A Ayerza, Lester Chan, Stephane Cherix, Jorge de Las Heras, Davide Donati, Uwale Eyesan, Nicola Fabbri, Michelle Ghert, Thomas Hilton, Oluwaseyi Kayode Idowu, Jungo Imanishi, Ajay Puri, Peter Rose, Dundar Sabah, Robert Turcotte, Kristy Weber, Michelle M Dowsey, Peter F M Choong

BMJ Open

September 2, 2021

OBJECTIVES: The COVID-19 pandemic is unprecedented as a global crisis over the last century. How do specialist surgeons make decisions about patient care in these unprecedent times? DESIGN: Between April…

Spread of Misinformation About Face Masks and COVID-19 by Automated Software on Facebook.

Written by John W Ayers, Brian Chu, Zechariah Zhu, Eric C Leas, Davey M Smith, Mark Dredze, David A Broniatowski

JAMA Intern Med

September 1, 2021

Rapid, Large-Scale Wastewater Surveillance and Automated Reporting System Enable Early Detection of Nearly 85% of COVID-19 Cases on a University Campus.

Written by Smruthi Karthikeyan, Andrew Nguyen, Daniel McDonald, Yijian Zong, Nancy Ronquillo, Junting Ren, Jingjing Zou, Sawyer Farmer, Greg Humphrey, Diana Henderson, Tara Javidi, Karen Messer, Cheryl Anderson, Robert Schooley, Natasha K Martin, Rob Knight

August 31, 2021

Wastewater-based surveillance has gained prominence and come to the forefront as a leading indicator of forecasting COVID-19 (coronavirus disease 2019) infection dynamics owing to its cost-effectiveness and its ability to…

Implementation of Patient Engagement Tools in Electronic Health Records to Enhance Patient-Centered Communication: Protocol for Feasibility Evaluation and Preliminary Results.

Written by Ming Tai-Seale, Rebecca Rosen, Bernice Ruo, Michael Hogarth, Christopher A Longhurst, Lina Lander, Amanda L Walker, Cheryl D Stults, Albert Chan, Kathleen Mazor, Lawrence Garber, Marlene Millen

JMIR Res Protoc

August 26, 2021

BACKGROUND: Patient-physician communication during clinical encounters is essential to ensure quality of care. Many studies have attempted to improve patient-physician communication. Incorporating patient priorities into agenda setting and medical decision-making…

Age-dependent regulation of SARS-CoV-2 cell entry genes and cell death programs correlates with COVID-19 severity.

Written by Zintis Inde, Ben A Croker, Clarence Yapp, Gaurav N Joshi, Johan Spetz, Cameron Fraser, Xingping Qin, Le Xu, Brian Deskin, Elisa Ghelfi, Gabrielle Webb, Aaron F Carlin, Yanfang Peipei Zhu, Sandra L Leibel, Aaron F Garretson, Alex E Clark, Jason M Duran, Victor Pretorius, Laura E Crotty-Alexander, Chendi Li, Jamie Casey Lee, Chhinder Sodhi, David J Hackam, Xin Sun, Aaron N Hata, Lester Kobzik, Jeffrey Miller, Jin-Ah Park, Douglas Brownfield, Hongpeng Jia, Kristopher A Sarosiek

Sci Adv

August 18, 2021

Novel coronavirus disease 2019 (COVID-19) severity is highly variable, with pediatric patients typically experiencing less severe infection than adults and especially the elderly. The basis for this difference is unclear.…

Characteristics of emergency room visits in patients with facial injuries in mainland China during the 60-day level I emergency response to COVID-19.

Int J Inj Contr Saf Promot

Written by Yi Zhang, Ying Liu, Tingliang Wang, Jiasheng Dong, Hua Xu

August 17, 2021

Chinese mainland launched the 60-day first-level response to major public health emergencies during the COVID-19 outbreak. This study aimed to determine the incidence and describe the characteristics and predictors of…

The application of artificial intelligence and data integration in COVID-19 studies: a scoping review.

Written by Yi Guo, Yahan Zhang, Tianchen Lyu, Mattia Prosperi, Fei Wang, Hua Xu, Jiang Bian

August 13, 2021

OBJECTIVE: To summarize how artificial intelligence (AI) is being applied in COVID-19 research and determine whether these AI applications integrated heterogenous data from different sources for modeling. MATERIALS AND METHODS:…

Dataset on optimization and development of a point-of-care glucometer-based SARS-CoV-2 detection assay using aptamers.

Written by Naveen K Singh, Partha Ray, Aaron F Carlin, Sydney C Morgan, Celestine Magallanes, Louise C Laurent, Eliah S Aronoff-Spencer, Drew A Hall

Data Brief

August 12, 2021

We present supplementary data for the published article, "Hitting the diagnostic sweet spot: Point-of-care SARS-CoV-2 salivary antigen testing with an off-the-shelf glucometer" [1]. The assay described is designed to be…

Broad-spectrum in vitro antiviral activity of ODBG-P-RVn: an orally-available, lipid-modified monophosphate prodrug of remdesivir parent nucleoside (GS-441524)

Written by Michael K Lo, Punya Shrivastava-Ranjan, Payel Chatterjee, Mike Flint, James R Beadle, Nadejda Valiaeva, Robert Schooley, Karl Y. Hostetler, Joel Montgomery, Christina F Spiropoulou

August 8, 2021

The intravenous administration of remdesivir for COVID-19 confines its utility to hospitalized patients. We evaluated the broad-spectrum antiviral activity of ODBG-P-RVn, an orally available, lipid-modified monophosphate prodrug of the remdesivir…

Privacy-protecting, reliable response data discovery using COVID-19 patient observations.

Written by Jihoon Kim, Larissa Neumann, Paulina Paul, Michele E Day, Michael Aratow, Douglas S Bell, Jason N Doctor, Ludwig C Hinske, Xiaoqian Jiang, Katherine K Kim, Michael E Matheny, Daniella Meeker, Mark J Pletcher, Lisa M Schilling, Spencer SooHoo, Hua Xu, Kai Zheng, Lucila Ohno-Machado

July 30, 2021

OBJECTIVE: To utilize, in an individual and institutional privacy-preserving manner, electronic health record (EHR) data from 202 hospitals by analyzing answers to COVID-19-related questions and posting these answers online. MATERIALS…

Introduction to the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS CoV-2) Supplement.

Written by Robert T Schooley

July 30, 2021

Analytical and Clinical Performance of Droplet Digital PCR in the Detection and Quantification of SARS-CoV-2.

Written by Kyoung Bo Kim, Hayoung Choi, Gun Dong Lee

Mol Diagn Ther

July 28, 2021

BACKGROUND AND OBJECTIVE: Since the initial coronavirus disease outbreak in late 2019 (COVID-19), reverse-transcription real-time polymerase chain reaction (RT-qPCR) has become the gold standard test to detect severe acute respiratory…

Impact of SARS-CoV-2 variants on the total CD4

Written by Alison Tarke, John Sidney, Nils Methot, Esther Dawen Yu, Yun Zhang, Jennifer M Dan, Benjamin Goodwin, Paul Rubiro, Aaron Sutherland, Eric Wang, April Frazier, Sydney I Ramirez, Stephen A Rawlings, Davey M Smith, Ricardo da Silva Antunes, Bjoern Peters, Richard H Scheuermann, Daniela Weiskopf, Shane Crotty, Alba Grifoni, Alessandro Sette

Cell Rep Med

July 20, 2021

The emergence of SARS-CoV-2 variants with evidence of antibody escape highlight the importance of addressing whether the total CD4+ and CD8+ T cell recognition is also affected. Here, we compare…

The impact of social distancing, contact tracing, and case isolation interventions to suppress the COVID-19 epidemic: A modeling study.

Written by Yang Ge, Zhiping Chen, Andreas Handel, Leonardo Martinez, Qian Xiao, Changwei Li, Enfu Chen, Jinren Pan, Yang Li, Feng Ling, Ye Shen

Epidemics

July 13, 2021

INTRODUCTION: Most countries are dependent on nonpharmaceutical public health interventions such as social distancing, contact tracing, and case isolation to mitigate COVID-19 spread until medicines or vaccines widely available. Minimal…

A human three-dimensional neural-perivascular 'assembloid' promotes astrocytic development and enables modeling of SARS-CoV-2 neuropathology.

Written by Lu Wang, David Sievert, Alex E Clark, Sangmoon Lee, Hannah Federman, Benjamin D Gastfriend, Eric V Shusta, Sean P Palecek, Aaron F Carlin, Joseph G Gleeson

Nat Med

July 9, 2021

Clinical evidence suggests the central nervous system is frequently impacted by SARS-CoV-2 infection, either directly or indirectly, although the mechanisms are unclear. Pericytes are perivascular cells within the brain that…

Searching for scientific evidence in a pandemic: An overview of TREC-COVID.

Written by Kirk Roberts, Tasmeer Alam, Steven Bedrick, Dina Demner-Fushman, Kyle Lo, Ian Soboroff, Ellen Voorhees, Lucy Lu Wang, William R Hersh

J Biomed Inform

July 8, 2021

We present an overview of the TREC-COVID Challenge, an information retrieval (IR) shared task to evaluate search on scientific literature related to COVID-19. The goals of TREC-COVID include the construction…

Spike protein cleavage-activation mediated by the SARS-CoV-2 P681R mutation: a case-study from its first appearance in variant of interest (VOI) A.23.1 identified in Uganda

Preprints

Written by Laura Frazier, et al.

July 1, 2021

The African continent is currently notable as a source of novel SARS-CoV-2 variants. The A.23 viral lineage, characterized by three spike mutations F157L, V367F and Q613H, was first identified in…

Stay-at-home orders and the willingness to stay home during the COVID-19 pandemic: A stated-preference discrete choice experiment.

Peer reviewed pubs

Written by Liqing Li, et al.

July 1, 2021

The spread of COVID-19 in the Spring of 2020 prompted state and local governments to implement a variety of policies, including stay-at-home (SAH) orders and mandatory mask requirements, aimed at…

Rapid, large-scale wastewater surveillance and automated reporting system enabled early detection of nearly 85% of COVID-19 cases on a University campus

June 27, 2021

Wastewater based surveillance has gained prominence and come to the forefront as a leading indicator of forecasting COVID-19 infection dynamics owing to its cost-effectiveness and its ability to inform early…

Dyslipidemia Is Related to Mortality in Critical Patients With Coronavirus Disease 2019: A Retrospective Study.

Front Endocrinol (Lausanne)

Written by Jiang Yue, Hua Xu, Yong Zhou, Wen Liu, Xiaofeng Han, Qing Mao, Shengxian Li, Lai-Shan Tam, Jing Ma, Wei Liu

June 23, 2021

Background: It has been reported that dyslipidemia is related to coronavirus-related diseases. Critical patients with coronavirus disease 2019 (COVID-19) who suffered from multiple organ dysfunctions were treated in the intensive…

Mask-off policy in the shadow of emerging variants of SARS-COV-2.

Other

Eur J Intern Med

Written by Abdolrazagh Hashemi Shahraki, Majid Vahed, Mehdi Mirsaeidi

June 18, 2021

COVID-19-Lessons Learned and Questions Remaining.

Written by Ferric C Fang, Constance A Benson, Carlos Del Rio, Kathryn M Edwards, Vance G Fowler, David N Fredricks, Ajit P Limaye, Barbara E Murray, Susanna Naggie, Peter G Pappas, Robin Patel, David L Paterson, David A Pegues, William A Petri, Robert T Schooley

June 15, 2021

In this article, the editors of Clinical Infectious Diseases review some of the most important lessons they have learned about the epidemiology, clinical features, diagnosis, treatment and prevention of SARS-CoV-2…

Comprehensive characterization of COVID-19 patients with repeatedly positive SARS-CoV-2 tests using a large US electronic health record database

Written by Xiao Dong, Yujia Zhou, Xiao-ou Shu, Elmer Bernstam, Rebecca Stern, David Aronoff, Hua Xu, Loren Lipworth

June 13, 2021

BackgroundIn the absence of genome sequencing, two positive molecular SARS-CoV-2 tests separated by negative tests, prolonged time, and symptom resolution remain the best surrogate measure of possible re-infection.

MethodsUsing a…

COVID-19 SignSym: a fast adaptation of a general clinical NLP tool to identify and normalize COVID-19 signs and symptoms to OMOP common data model.

Written by Jingqi Wang, Noor Abu-El-Rub, Josh Gray, Huy Anh Pham, Yujia Zhou, Frank J Manion, Mei Liu, Xing Song, Hua Xu, Masoud Rouhizadeh, Yaoyun Zhang

June 12, 2021

The COVID-19 pandemic swept across the world rapidly, infecting millions of people. An efficient tool that can accurately recognize important clinical concepts of COVID-19 from free text in electronic health…

AI-guided discovery of the invariant host response to viral pandemics.

Written by Debashis Sahoo, Gajanan D Katkar, Soni Khandelwal, Mahdi Behroozikhah, Amanraj Claire, Vanessa Castillo, Courtney Tindle, MacKenzie Fuller, Sahar Taheri, Thomas F Rogers, Nathan Beutler, Sydney I Ramirez, Stephen A Rawlings, Victor Pretorius, Davey M Smith, Dennis R Burton, Laura E Crotty Alexander, Jason Duran, Shane Crotty, Jennifer M Dan, Soumita Das, Pradipta Ghosh

EBioMedicine

June 11, 2021

BACKGROUND: Coronavirus Disease 2019 (Covid-19) continues to challenge the limits of our knowledge and our healthcare system. Here we sought to define the host immune response, a.k.a, the "cytokine storm"…

Dramatic Increases in Telehealth-Related Tweets during the Early COVID-19 Pandemic: A Sentiment Analysis.

Written by Tiffany Champagne-Langabeer, Michael W Swank, Shruthi Manas, Yuqi Si, Kirk Roberts

Healthcare (Basel)

May 27, 2021

The COVID-19 pandemic resulted in a large expansion of telehealth, but little is known about user sentiment. Tweets containing the terms "telehealth" and "telemedicine" were extracted (n = 192,430) from…

A systematic review and meta-analysis on correlation of weather with COVID-19.

Written by Poulami Majumder, Partha Pratim Ray

Sci Rep

May 24, 2021

This study presents a systematic review and meta-analysis over the findings of significance of correlations between weather parameters (temperature, humidity, rainfall, ultra violet radiation, wind speed) and COVID-19. The meta-analysis…

Cross-reactive serum and memory B-cell responses to spike protein in SARS-CoV-2 and endemic coronavirus infection.

Written by Ge Song, Wan-Ting He, Sean Callaghan, Fabio Anzanello, Deli Huang, James Ricketts, Jonathan L Torres, Nathan Beutler, Linghang Peng, Sirena Vargas, Jon Cassell, Mara Parren, Linlin Yang, Caroline Ignacio, Davey M Smith, James E Voss, David Nemazee, Andrew B Ward, Thomas Rogers, Dennis R Burton, Raiees Andrabi

May 19, 2021

Pre-existing immunity to seasonal endemic coronaviruses could have profound consequences for antibody responses to SARS-CoV-2, induced from natural infection or vaccination. A first step to establish whether pre-existing responses can…

Interactions of SARS-CoV-2 envelope protein with amilorides correlate with antiviral activity.

Written by Sang Ho Park, Haley Siddiqi, Daniela V Castro, Anna A De Angelis, Aaron L Oom, Charlotte A Stoneham, Mary K Lewinski, Alex E Clark, Ben A Croker, Aaron F Carlin, John Guatelli, Stanley J Opella

PLoS Pathog

May 18, 2021

SARS-CoV-2 is the novel coronavirus that is the causative agent of COVID-19, a sometimes-lethal respiratory infection responsible for a world-wide pandemic. The envelope (E) protein, one of four structural proteins…

Hitting the diagnostic sweet spot: Point-of-care SARS-CoV-2 salivary antigen testing with an off-the-shelf glucometer.

Written by Naveen K Singh, Partha Ray, Aaron F Carlin, Celestine Magallanes, Sydney C Morgan, Louise C Laurent, Eliah S Aronoff-Spencer, Drew A Hall

Biosens Bioelectron

May 15, 2021

Significant barriers to the diagnosis of latent and acute SARS-CoV-2 infection continue to hamper population-based screening efforts required to contain the COVID-19 pandemic in the absence of widely available antiviral…

METTL3 regulates viral m6A RNA modification and host cell innate immune responses during SARS-CoV-2 infection.

Written by Na Li, Hui Hui, Bill Bray, Gwendolyn Michelle Gonzalez, Mark Zeller, Kristian G Anderson, Rob Knight, Davey Smith, Yinsheng Wang, Aaron F Carlin, Tariq M Rana

Cell Rep

May 11, 2021

It is urgent and important to understand the relationship of the widespread severe acute respiratory syndrome coronavirus clade 2 (SARS-CoV-2) with host immune response and study the underlining molecular mechanism.…

SARS-CoV-2 Infection after Vaccination in Health Care Workers in California.

Written by Jocelyn Keehner, Lucy E Horton, Michael A Pfeffer, Christopher A Longhurst, Robert T Schooley, Judith S Currier, Shira R Abeles, Francesca J Torriani

N Engl J Med

May 6, 2021

Ten scientific reasons in support of airborne transmission of SARS-CoV-2.

Written by Trisha Greenhalgh, Jose L Jimenez, Kimberly A Prather, Zeynep Tufekci, David Fisman, Robert Schooley

Lancet

May 1, 2021

A Clinical-Stage Cysteine Protease Inhibitor blocks SARS-CoV-2 Infection of Human and Monkey Cells.

Written by Drake M Mellott, Chien-Te Tseng, Aleksandra Drelich, Pavla Fajtová, Bala C Chenna, Demetrios H Kostomiris, Jason Hsu, Jiyun Zhu, Zane W Taylor, Klaudia I Kocurek, Vivian Tat, Ardala Katzfuss, Linfeng Li, Miriam A Giardini, Danielle Skinner, Ken Hirata, Michael C Yoon, Sungjun Beck, Aaron F Carlin, Alex E Clark, Laura Beretta, Daniel Maneval, Vivian Hook, Felix Frueh, Brett L Hurst, Hong Wang, Frank M Raushel, Anthony J O'Donoghue, Jair Lage de Siqueira-Neto, Thomas D Meek, James H McKerrow

ACS Chem Biol

April 16, 2021

Host-cell cysteine proteases play an essential role in the processing of the viral spike protein of SARS coronaviruses. K777, an irreversible, covalent inactivator of cysteine proteases that has recently completed…

COVID-19 vaccine delivery: an opportunity to set up systems for the future.

Written by Rebecca Weintraub, Stanley Plotkin, Margaret Liu, Jerome Kim, Natalie Garcon, David Bell, Dan Storisteanu, Toby Norman, Eliah Aronoff-Spencer

Gates Open Res

April 14, 2021

The race to develop safe and effective SARS-COV-2 vaccines has moved with unprecedented speed. There are now multiple vaccines that have received emergency use authorization from the United States Food…

Interactions of SARS-CoV-2 envelope protein with amilorides correlate with antiviral activity

Written by Sang Ho Park, Haley Siddiqi, Daniela Castro, Anna De Angelis, Aaron L. Oom, Charlotte Stoneham, Mary Lewinski, Alex Clark, Ben Croker, Aaron Carlin, John Guatelli, Stanley J. Opella

April 6, 2021

Comparison of two nucleic acid amplification tests (NAATs) and two antigen tests for detection of SARS-CoV-2 from upper respiratory specimens.

Written by Peiting Kuo, Susan Realegeno, David T Pride

J Clin Virol Plus

April 3, 2021

There are numerous tests available for acute diagnosis of SARS-CoV-2, the virus that causes the disease COVID-19. These tests fall into two main groups: nucleic acid amplification tests (NAATs) and…

How do we share data in COVID-19 research? A systematic review of COVID-19 datasets in PubMed Central Articles.

Written by Xu Zuo, Yong Chen, Lucila Ohno-Machado, Hua Xu

Brief Bioinform

March 22, 2021

OBJECTIVE: This study aims at reviewing novel coronavirus disease (COVID-19) datasets extracted from PubMed Central articles, thus providing quantitative analysis to answer questions related to dataset contents, accessibility and citations.…

Health Impacts of the Stay-at-Home Order on Community-Dwelling Older Adults and How Technologies May Help: Focus Group Study.

Written by Jessica R Daly, Colin Depp, Sarah A Graham, Dilip V Jeste, Ho-Cheol Kim, Ellen E Lee, Camille Nebeker

JMIR Aging

March 22, 2021

BACKGROUND: As of March 2021, in the USA, the COVID-19 pandemic has resulted in over 500,000 deaths, with a majority being people over 65 years of age. Since the start…

Can't Work From Home: Pooled Nucleic Acid Testing of Laboratory Workers During the COVID-19 Pandemic.

Written by Stephen A Rawlings, Brianna Scott, Laura Layman, Pramod Naranatt, Roy Heltsley, Caroline Ignacio, Magali Porrachia, Sara Gianella, Davey Smith, Antoine Chaillon

March 15, 2021

Together with protective measures, routine screening for severe acute respiratory syndrome coronavirus 2 infection helps provide a safe working environment. We evaluated a pooled nucleic acid testing strategy in a…

Revealing Tissue-Specific SARS-CoV-2 Infection and Host Responses using Human Stem Cell-Derived Lung and Cerebral Organoids.

Written by Shashi Kant Tiwari, Shaobo Wang, Davey Smith, Aaron F Carlin, Tariq M Rana

Stem Cell Reports

March 9, 2021

COVID-19 is a transmissible respiratory disease caused by a novel coronavirus, SARS-CoV-2, and has become a global health emergency. There is an urgent need for robust and practical in vitro…

Response to pegylated interferon in a COVID-19-positive elderly woman with primary myelofibrosis treated with ruxolitinib.

Written by Arthur E Frankel, Renuka Reddy, Kayla R DeSuza, Khaled Deeb, Aaron F Carlin, Davey Smith, Yushuang Xie, Eknath Naik, Richard T Silver, Hans C Hasselbalch

Clin Case Rep

March 7, 2021

An 83-year-old female had asymptomatic SARS-CoV-2 infection while taking ruxolitinib. She remained RT-PCR positive for viral RNA for >120 days, and Pegylated interferon for 4 weeks led to viral RNA…

RAMIC: Design of a randomized, double-blind, placebo-controlled trial to evaluate the efficacy of ramipril in patients with COVID-19.

Clinical Trial Protocol

Contemp Clin Trials

Written by Veeral Ajmera, Wesley K Thompson, Davey M Smith, Atul Malhotra, Ravindra L Mehta, Vaishal Tolia, Jeffrey Yin, Krishna Sriram, Paul A Insel, Summer Collier, Lisa Richards, Rohit Loomba

February 22, 2021

BACKGROUND AND AIMS: Retrospective studies have shown that angiotensin-converting-enzyme (ACE) inhibitors are associated with a reduced risk of complications and mortality in persons with novel coronavirus disease 2019 (COVID-19). Thus,…

Radiomics analysis enables fatal outcome prediction for hospitalized patients with coronavirus disease 2019 (COVID-19).

Written by Zan Ke, Liang Li, Li Wang, Huan Liu, Xuefang Lu, Feifei Zeng, Yunfei Zha

Acta Radiol

February 18, 2021

BACKGROUND: In December 2019, a rare respiratory disease named coronavirus disease 2019 (COVID-19) broke out, leading to great concern around the world. PURPOSE: To develop and validate a radiomics nomogram…

VIC Foundry, Inc. Receives NIH RADx Funding for Development of an At-home Molecular Diagnostic Test for COVID-19

Peer reviewed pubs

Written by newsfeed

February 16, 2021

VIC Foundry's innovative designs for a low-cost at-home COVID-19 test Funding for the project is being provided by the National Institutes of Health (NIH) Rapid Acceleration of Diagnostics (RADx) Tech…

Comprehensive analysis of T cell immunodominance and immunoprevalence of SARS-CoV-2 epitopes in COVID-19 cases.

Written by Alison Tarke, John Sidney, Conner K Kidd, Jennifer M Dan, Sydney I Ramirez, Esther Dawen Yu, Jose Mateus, Ricardo da Silva Antunes, Erin Moore, Paul Rubiro, Nils Methot, Elizabeth Phillips, Simon Mallal, April Frazier, Stephen A Rawlings, Jason A Greenbaum, Bjoern Peters, Davey M Smith, Shane Crotty, Daniela Weiskopf, Alba Grifoni, Alessandro Sette

Cell Rep Med

February 16, 2021

T cells are involved in control of SARS-CoV-2 infection. To establish the patterns of immunodominance of different SARS-CoV-2 antigens and precisely measure virus-specific CD4+ and CD8+ T cells, we study…

Use of electronic health records to support a public health response to the COVID-19 pandemic in the United States: a perspective from 15 academic medical centers.

Written by Subha Madhavan, Lisa Bastarache, Jeffrey S Brown, Atul J Butte, David A Dorr, Peter J Embi, Charles P Friedman, Kevin B Johnson, Jason H Moore, Isaac S Kohane, Philip R O Payne, Jessica D Tenenbaum, Mark G Weiner, Adam B Wilcox, Lucila Ohno-Machado

February 15, 2021

Our goal is to summarize the collective experience of 15 organizations in dealing with uncoordinated efforts that result in unnecessary delays in understanding, predicting, preparing for, containing, and mitigating the…

Multi-clonal SARS-CoV-2 neutralization by antibodies isolated from severe COVID-19 convalescent donors.

Written by Michael Mor, Michal Werbner, Joel Alter, Modi Safra, Elad Chomsky, Jamie C Lee, Smadar Hada-Neeman, Ksenia Polonsky, Cameron J Nowell, Alex E Clark, Anna Roitburd-Berman, Noam Ben-Shalom, Michal Navon, Dor Rafael, Hila Sharim, Evgeny Kiner, Eric R Griffis, Jonathan M Gershoni, Oren Kobiler, Sandra Lawrynowicz Leibel, Oren Zimhony, Aaron F Carlin, Gur Yaari, Moshe Dessau, Meital Gal-Tanamy, David Hagin, Ben A Croker, Natalia T Freund

PLoS Pathog

February 11, 2021

The interactions between antibodies, SARS-CoV-2 and immune cells contribute to the pathogenesis of COVID-19 and protective immunity. To understand the differences between antibody responses in mild versus severe cases of…

A Human 3D neural assembloid model for SARS-CoV-2 infection

Written by Joseph G Gleeson, Lu Wang, David Sievert, Alex E Clark, Hannah Federman, Benjamin D Gastfriend, Eric Shusta, Sean Palecek, Aaron Carlin, Alex E. Clark

February 9, 2021

Clinical evidence suggests the central nervous system (CNS) is frequently impacted by SARS-CoV-2 infection, either directly or indirectly, although mechanisms remain unclear. Pericytes are perivascular cells within the brain that…

Immunological memory to SARS-CoV-2 assessed for up to 8 months after infection.

Written by Jennifer M Dan, Jose Mateus, Yu Kato, Kathryn M Hastie, Esther Dawen Yu, Caterina E Faliti, Alba Grifoni, Sydney I Ramirez, Sonya Haupt, April Frazier, Catherine Nakao, Vamseedhar Rayaprolu, Stephen A Rawlings, Bjoern Peters, Florian Krammer, Viviana Simon, Erica Ollmann Saphire, Davey M Smith, Daniela Weiskopf, Alessandro Sette, Shane Crotty

February 5, 2021

Understanding immune memory to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is critical for improving diagnostics and vaccines and for assessing the likely future course of the COVID-19 pandemic. We…

An evaluation of two commercial deep learning-based information retrieval systems for COVID-19 literature.

Evaluation Study

Written by Sarvesh Soni, Kirk Roberts

January 15, 2021

The COVID-19 pandemic has resulted in a tremendous need for access to the latest scientific information, leading to both corpora for COVID-19 literature and search engines to query such data.…

Knowledge, attitude, and preventive behaviors of Hormozgan residents toward COVID-19, one month after the epidemic in Iran.

Written by Nahid Shahabi, Hesamaddin Kamalzadeh Takhti, Mehdi Hassani Azad, Roghayeh Ezati Rad, Hamid Reza Ghaffari, Shokrollah Mohseni, Teamur Aghamolaei, Fatemeh Norozian

Z Gesundh Wiss

January 7, 2021

Aim: COVID-19 has become prevalent in the world since December 2019. The further prevalence of the disease can be prevented by correct management of society and increasing knowledge, practices, and…

What the HIV Pandemic Experience Can Teach the United States About the COVID-19 Response.

J Acquir Immune Defic Syndr

Written by Steffanie A Strathdee, Natasha K Martin, Eileen V Pitpitan, Jamila K Stockman, Davey M Smith

January 1, 2021

Computing SARS-CoV-2 Infection Risk From Symptoms, Imaging, and Test Data: Diagnostic Model Development.

Written by Christopher D'Ambrosia, Henrik Christensen, Eliah Aronoff-Spencer

J Med Internet Res

December 16, 2020

BACKGROUND: Assigning meaningful probabilities of SARS-CoV-2 infection risk presents a diagnostic challenge across the continuum of care. OBJECTIVE: The aim of this study was to develop and clinically validate an…

Immunological memory to SARS-CoV-2 assessed for greater than six months after infection

Written by Jennifer M Dan, Jose Mateus, Yu Kato, Kathryn M Hastie, Esther D Yu, Caterina Faliti, Alba Grifoni, Sydney I Ramirez, Sonya Haupt, April Frazier, Catherine Nakao, Vamseedhar Rayaprolu, Stephen A Rawlings, Bjoern Peters, Florian Krammer, Viviana Simon, Erica O Saphire, Davey Smith, Daniela Weiskopf, Alessandro Sette, Shane Crotty

November 16, 2020

Understanding immune memory to SARS-CoV-2 is critical for improving diagnostics and vaccines, and for assessing the likely future course of the COVID-19 pandemic. We analyzed multiple compartments of circulating immune…

A smartphone-based online tool for prehospital self-triage of COVID-19.

Written by Juan Yu, Han-Wen Zhang, Yuan-Kai Shao, Yi Lei, Huan Chen, Zu-Hui Pu, Fan Lin, Hua-Jian Xu, Yu-Li Wang, Chao Liang, Li-Hong Liu, Xia-Jing Liu, Wei-Cai Dai

Chin J Acad Radiol

November 16, 2020

The COVID-19 epidemic has swept across China and spread to other countries. The rapid spreading of COVID-19 and panic combined with the lack of a hierarchical medical system in China…

SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2.

Written by Thomas Mandel Clausen, Daniel R Sandoval, Charlotte B Spliid, Jessica Pihl, Hailee R Perrett, Chelsea D Painter, Anoop Narayanan, Sydney A Majowicz, Elizabeth M Kwong, Rachael N McVicar, Bryan E Thacker, Charles A Glass, Zhang Yang, Jonathan L Torres, Gregory J Golden, Phillip L Bartels, Ryan N Porell, Aaron F Garretson, Logan Laubach, Jared Feldman, Xin Yin, Yuan Pu, Blake M Hauser, Timothy M Caradonna, Benjamin P Kellman, Cameron Martino, Philip L S M Gordts, Sumit K Chanda, Aaron G Schmidt, Kamil Godula, Sandra L Leibel, Joyce Jose, Kevin D Corbett, Andrew B Ward, Aaron F Carlin, Jeffrey D Esko

November 12, 2020

We show that SARS-CoV-2 spike protein interacts with both cellular heparan sulfate and angiotensin-converting enzyme 2 (ACE2) through its receptor-binding domain (RBD). Docking studies suggest a heparin/heparan sulfate-binding site adjacent…

Antigen-Specific Adaptive Immunity to SARS-CoV-2 in Acute COVID-19 and Associations with Age and Disease Severity.

Written by Carolyn Rydyznski Moderbacher, Sydney I Ramirez, Jennifer M Dan, Alba Grifoni, Kathryn M Hastie, Daniela Weiskopf, Simon Belanger, Robert K Abbott, Christina Kim, Jinyong Choi, Yu Kato, Eleanor G Crotty, Cheryl Kim, Stephen A Rawlings, Jose Mateus, Long Ping Victor Tse, April Frazier, Ralph Baric, Bjoern Peters, Jason Greenbaum, Erica Ollmann Saphire, Davey M Smith, Alessandro Sette, Shane Crotty

November 12, 2020

Limited knowledge is available on the relationship between antigen-specific immune responses and COVID-19 disease severity. We completed a combined examination of all three branches of adaptive immunity at the level…

Deployment of artificial intelligence for radiographic diagnosis of COVID-19 pneumonia in the emergency department.

J Am Coll Emerg Physicians Open

Written by Morgan Carlile, Brian Hurt, Albert Hsiao, Michael Hogarth, Christopher A Longhurst, Christian Dameff

November 5, 2020

OBJECTIVE: The coronavirus disease 2019 pandemic has inspired new innovations in diagnosing, treating, and dispositioning patients during high census conditions with constrained resources. Our objective is to describe first experiences…

Cholesterol 25-Hydroxylase inhibits SARS-CoV-2 and other coronaviruses by depleting membrane cholesterol.

Written by Shaobo Wang, Wanyu Li, Hui Hui, Shashi Kant Tiwari, Qiong Zhang, Ben A Croker, Stephen Rawlings, Davey Smith, Aaron F Carlin, Tariq M Rana

EMBO J

November 2, 2020

Coronavirus disease 2019 (COVID-19) is caused by SARS-CoV-2 and has spread across the globe. SARS-CoV-2 is a highly infectious virus with no vaccine or antiviral therapy available to control the…

Impaired natural killer cell counts and cytolytic activity in patients with severe COVID-19.

Written by Mohammed Osman, Rehan M Faridi, Wendy Sligl

Blood Adv

October 27, 2020

The global pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-driven coronavirus disease 2019 (COVID-19) has caused unprecedented human death and has seriously threatened the global economy. Early data suggest…

Antiretroviral Drugs for Treatment and Prevention of HIV Infection in Adults: 2020 Recommendations of the International Antiviral Society-USA Panel.

Written by Michael S Saag, Rajesh T Gandhi, Jennifer F Hoy, Raphael J Landovitz, Melanie A Thompson, Paul E Sax, Davey M Smith, Constance A Benson, Susan P Buchbinder, Carlos Del Rio, Joseph J Eron, Gerd Fätkenheuer, Huldrych F Günthard, Jean-Michel Molina, Donna M Jacobsen, Paul A Volberding

JAMA

October 27, 2020

Importance: Data on the use of antiretroviral drugs, including new drugs and formulations, for the treatment and prevention of HIV infection continue to guide optimal practices. Objective: To evaluate new…

Airborne transmission of SARS-CoV-2.

Written by Kimberly A Prather, Linsey C Marr, Robert T Schooley, Melissa A McDiarmid, Mary E Wilson, Donald K Milton

October 16, 2020

Selective and cross-reactive SARS-CoV-2 T cell epitopes in unexposed humans.

Written by Jose Mateus, Alba Grifoni, Alison Tarke, John Sidney, Sydney I Ramirez, Jennifer M Dan, Zoe C Burger, Stephen A Rawlings, Davey M Smith, Elizabeth Phillips, Simon Mallal, Marshall Lammers, Paul Rubiro, Lorenzo Quiambao, Aaron Sutherland, Esther Dawen Yu, Ricardo da Silva Antunes, Jason Greenbaum, April Frazier, Alena J Markmann, Lakshmanane Premkumar, Aravinda de Silva, Bjoern Peters, Shane Crotty, Alessandro Sette, Daniela Weiskopf

October 2, 2020

Many unknowns exist about human immune responses to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus. SARS-CoV-2-reactive CD4+ T cells have been reported in unexposed individuals, suggesting preexisting cross-reactive…

Rationale for American Society of Retina Specialists Best Practice Recommendations for Conducting Vitreoretinal Surgery during the COVID-19 Era.

Written by Daniel L Chao, Jayanth Sridhar, Ajay E Kuriyan, Theodore Leng, Brad P Barnett, Aaron F Carlin, Charles C Wykoff, Stephen Gayer, Prithvi Mruthyunjaya, Yoshihiro Yonekawa, Amani A Fawzi, Audina M Berrocal, Steven Yeh, Daniel Ting, Yasha Modi, David N Zacks, Nicholas Yannuzzi, Natalie A Afshari, Timothy Murray

J Vitreoretin Dis

October 1, 2020

PURPOSE: To detail the rationale behind recommendations recently published by the American Society of Retina Specialists (ASRS) outlining best practices for safety of vitreoretinal surgeons and staff while performing vitreoretinal…

Existing drug treatments cannot significantly shorten the clinical cure time of children with COVID-19.

Written by Mengting Li, Yang Wang, Hua Xu, Changlin Liu, Liang Shi, Qi Ye, Jun Wang, Sichan Li, Yan Mei, Liuliu Gao

J Infect Dev Ctries

September 30, 2020

INTRODUCTION: COVID-19 has become a global health security issue, it has caused more than half a million deaths worldwide so far, the treatment strategies are the most concerned issues for…

Hitting the diagnostic sweet spot: Point-of-care SARS-CoV-2 salivary antigen testing with an off-the-shelf glucometer

Written by Naveen K Singh, Partha Ray, Aaron F Carlin, Celestine Magallanes, Sydney Morgan, Louise C Laurent, Eliah Aronoff-Spencer, Drew A. Hall

September 25, 2020

Subclinical ocular inflammation in persons recovered from ambulatory COVID-19

Written by Mathieu F Bakhoum, Michele Ritter, Anupam Garg, Alison X Chan, Christine Y Bakhoum, Davey Smith

September 23, 2020

Coronavirus disease 2019 (COVID-19) is characterized by striking variability in clinical severity, and a hyperinflammatory response in the lung is associated with high mortality. Little is known about the extent…

Privacy-Protecting, Reliable Response Data Discovery Using COVID-19 Patient Observations

Written by Jihoon Kim, Larissa Neumann, Paulina Paul, Michael Aratow, Douglas S Bell, Jason N Doctor, Ludwig C Hinske, Xiaoqian Jiang, Katherine K Kim, Michael E Matheny, Daniella Meeker, Mark J Pletcher, Lisa M Schilling, Spencer SooHoo, Hua Xu, Kai Zheng, Lucila Ohno-Machado, - R2D2 Consortium

September 23, 2020

There is an urgent need to answer questions related to COVID-19s clinical course and associations with underlying conditions and health outcomes. Multi-center data are necessary to generate reliable answers, but…

Ruling In and Ruling Out COVID-19: Computing SARS-CoV-2 Infection Risk From Symptoms, Imaging and Test Data.

Written by Chistopher D'Ambrosia, Henrik Christensen, Eliah Aronoff-Spencer

September 22, 2020

BackgroundAssigning meaningful probabilities of SARS-CoV-2 infection risk presents a diagnostic challenge across the continuum of care.

MethodsWe integrated patient symptom and test data using machine learning and Bayesian inference to…

AI-guided discovery of the invariant host response to viral pandemics

Written by Debashis Sahoo, Gajanan D. Katkar, Soni Khandelwal, Mahdi Behroozikhah, Amanraj Claire, Vanessa Castillo, Courtney Tindle, MacKenzie Fuller, Sahar Taheri, Thomas F. Rogers, Nathan Beutler, Sydney Ramirez, Stephen A. Rawlings, Victor Pretorius, Davey Smith, Dennis R. Burton, Laura Crotty Alexander, Jason M. Duran, Shane Crotty, Jennifer M Dan, Soumita Das, Pradipta Ghosh

September 22, 2020

We sought to define the host immune response, a.k.a, the "cytokine storm" that has been implicated in fatal COVID-19 using an AI-based approach. Over 45,000 transcriptomic datasets of viral pandemics…

A comparison of droplet and contact contamination using 3 simulated barrier techniques for COVID-19 intubation: a quality assurance study.

Comparative Study

CMAJ Open

Written by Peter Rose, John Veall, Navraj Chima, Elena Vowels, Shruti Chitnis, Alana Flexman, Raymond Tang

August 31, 2020

BACKGROUND: The intubation of patients with coronavirus disease 2019 (COVID-19) puts health care workers at risk of infection through aerosol, droplet and contact contamination. We evaluated the risk of droplet…

Isolation of potent SARS-CoV-2 neutralizing antibodies and protection from disease in a small animal model.

Written by Thomas F Rogers, Fangzhu Zhao, Deli Huang, Nathan Beutler, Alison Burns, Wan-Ting He, Oliver Limbo, Chloe Smith, Ge Song, Jordan Woehl, Linlin Yang, Robert K Abbott, Sean Callaghan, Elijah Garcia, Jonathan Hurtado, Mara Parren, Linghang Peng, Sydney Ramirez, James Ricketts, Michael J Ricciardi, Stephen A Rawlings, Nicholas C Wu, Meng Yuan, Davey M Smith, David Nemazee, John R Teijaro, James E Voss, Ian A Wilson, Raiees Andrabi, Bryan Briney, Elise Landais, Devin Sok, Joseph G Jardine, Dennis R Burton

August 21, 2020

Countermeasures to prevent and treat coronavirus disease 2019 (COVID-19) are a global health priority. We enrolled a cohort of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-recovered participants, developed neutralization assays…

No Evidence of SARS-CoV-2 Seminal Shedding Despite SARS-CoV-2 Persistence in the Upper Respiratory Tract.

Written by Stephen A Rawlings, Caroline Ignacio, Magali Porrachia, Pinyi Du, Davey M Smith, Antoine Chaillon

August 7, 2020

RNA viruses (eg, Zika, Ebola, HIV) are often shed in male genital secretions. We evaluated the presence and level of SARS-CoV-2 RNA in semen, nasal secretion, and saliva collected after…

Risk Assessment and Prevention of Severe Acute Respiratory Syndrome Coronavirus 2 Transmission for Hospitalized Urological Patients After the COVID-19 Pandemic in Wuhan, China.

Written by Ejun Peng, Ding Xia, Wenxi Gao, Ying Zhan, Huan Yang, Xiaoqi Yang, Hua Xu, Xiaoling Qu, Jie Sun, Shaogang Wang, Zhangqun Ye, Kun Tang, Zhiqiang Chen

Eur Urol Open Sci

July 30, 2020

BACKGROUND: Emerging asymptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections were detected and multiple cases were found to be SARS-CoV-2 positive again, which raised an alarm for the patients…

Internet Searches About Infectious Diseases Training During the Coronavirus Disease 2019 Pandemic.

Written by Morgan Birabaharan, Davey M Smith, Darcy Wooten

July 21, 2020

The COVID- 19 pandemic has showcased the field of Infectious Diseases (ID). We used Google Trends to find that this newfound attention has led to higher interest in ID training.

…

Transmission and clinical characteristics of coronavirus disease 2019 in 104 outside-Wuhan patients, China.

Written by Chengfeng Qiu, Ziwei Deng, Qian Xiao, Yuanlu Shu, Ye Deng, Hongqiang Wang, Xin Liao, Huiwen Liu, Dinghui Zhou, Xiang Zhao, Jianliang Zhou, Jin Wang, Zhihua Shi, Da Long

J Med Virol

July 11, 2020

Cases of coronavirus disease 2019 (COVID-19) emigrating from Wuhan escalated the risk of spreading the disease in other cities. This report focused on outside-Wuhan patients to assess the transmission and…

Structures of potent and convergent neutralizing antibodies bound to the SARS-CoV-2 spike unveil a unique epitope responsible for exceptional potency

Written by Shuo Du, Yunlong Cao, Qinyu Zhu, Guopeng Wang, Xiaoxia Du, Runsheng He, Hua Xu, Yinghui Zheng, Bo Wang, Yali Bai, Chenggong Ji, Ayijiang Yisimayi, Qisheng Wang, Ning Gao, Sunney Xie, Xiao-dong Su, Junyu Xiao

July 9, 2020

Understanding the mechanism of neutralizing antibodies (NAbs) against SARS-CoV-2 is critical for effective vaccines and therapeutics development. We recently reported an exceptionally potent NAb, BD-368-2, and revealed the existence of…

TREC-COVID: rationale and structure of an information retrieval shared task for COVID-19.

Written by Kirk Roberts, Tasmeer Alam, Steven Bedrick, Dina Demner-Fushman, Kyle Lo, Ian Soboroff, Ellen Voorhees, Lucy Lu Wang, William R Hersh

July 1, 2020

TREC-COVID is an information retrieval (IR) shared task initiated to support clinicians and clinical research during the COVID-19 pandemic. IR for pandemics breaks many normal assumptions, which can be seen…

COVID-19 TestNorm: A tool to normalize COVID-19 testing names to LOINC codes.

Written by Xiao Dong, Jianfu Li, Ekin Soysal, Jiang Bian, Scott L DuVall, Elizabeth Hanchrow, Hongfang Liu, Kristine E Lynch, Michael Matheny, Karthik Natarajan, Lucila Ohno-Machado, Serguei Pakhomov, Ruth Madeleine Reeves, Amy M Sitapati, Swapna Abhyankar, Theresa Cullen, Jami Deckard, Xiaoqian Jiang, Robert Murphy, Hua Xu

July 1, 2020

Large observational data networks that leverage routine clinical practice data in electronic health records (EHRs) are critical resources for research on coronavirus disease 2019 (COVID-19). Data normalization is a key…

Sensitivity in Detection of Antibodies to Nucleocapsid and Spike Proteins of Severe Acute Respiratory Syndrome Coronavirus 2 in Patients With Coronavirus Disease 2019.

Written by Peter D Burbelo, Francis X Riedo, Chihiro Morishima, Stephen Rawlings, Davey Smith, Sanchita Das, Jeffrey R Strich, Daniel S Chertow, Richard T Davey, Jeffrey I Cohen

J Infect Dis

June 29, 2020

BACKGROUND: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of coronavirus disease 2019 (COVID-19), is associated with respiratory-related disease and death. Assays to detect virus-specific antibodies are important to…

Reducing transmission of SARS-CoV-2.

Written by Kimberly A Prather, Chia C Wang, Robert T Schooley

June 26, 2020

Targets of T Cell Responses to SARS-CoV-2 Coronavirus in Humans with COVID-19 Disease and Unexposed Individuals.

Written by Alba Grifoni, Daniela Weiskopf, Sydney I Ramirez, Jose Mateus, Jennifer M Dan, Carolyn Rydyznski Moderbacher, Stephen A Rawlings, Aaron Sutherland, Lakshmanane Premkumar, Ramesh S Jadi, Daniel Marrama, Aravinda M de Silva, April Frazier, Aaron F Carlin, Jason A Greenbaum, Bjoern Peters, Florian Krammer, Davey M Smith, Shane Crotty, Alessandro Sette

June 25, 2020

Understanding adaptive immunity to SARS-CoV-2 is important for vaccine development, interpreting coronavirus disease 2019 (COVID-19) pathogenesis, and calibration of pandemic control measures. Using HLA class I and II predicted peptide…

The efficacy of masks for influenza-like illness in the community: A protocol for systematic review and meta-analysis.

Written by Hua Wang, Mao-Bing Chen, Wei-Yan Cui, Hua-Lan Xu, Qi-Han Zheng

Medicine (Baltimore)

June 5, 2020

BACKGROUND: During the COVID-19 period, there was a huge gap in the understanding of masks between east and west. At the same time, the mechanism of the mask and the…

Risk Factors for Prolonged Invasive Mechanical Ventilation in COVID-19 Acute Respiratory Distress Syndrome

June 2, 2020

This multicentric prospective clinical practice study aims at evaluating clinical factors associated with a prolonged invasive mechanical ventilation and other outcomes such as mortality and ICU length of stay in…

Special Edition: COVID-19 Guest Editorial.

Editorial

J Am Acad Orthop Surg

Written by Peter Rose, William N Levine

June 1, 2020

Preparing a neurology department for SARS-CoV-2 (COVID-19): Early experiences at Columbia University Irving Medical Center and the New York Presbyterian Hospital in New York City.

Written by Genna Waldman, Richard Mayeux, Jan Claassen, Sachin Agarwal, Joshua Willey, Emily Anderson, Patricia Punzalan, Ryan Lichtcsien, Michelle Bell, Serge Przedborski, Christina Ulane, Kirk Roberts, Olajide Williams, Andrew B Lassman, Laura Lennihan, Kiran T Thakur

Neurology

May 19, 2020

Immediate psychological distress in quarantined patients with COVID-19 and its association with peripheral inflammation: A mixed-method study.

Written by Qian Guo, Yuchen Zheng, Jia Shi, Jijun Wang, Guanjun Li, Chunbo Li, John A Fromson, Yong Xu, Xiaohua Liu, Hua Xu, Tianhong Zhang, Yunfei Lu, Xiaorong Chen, Hao Hu, Yingying Tang, Shuwen Yang, Han Zhou, Xiaoliang Wang, Haiying Chen, Zhen Wang, Zongguo Yang

Brain Behav Immun

May 19, 2020

Since the end of 2019, Corona Virus Disease 2019 (COVID-19) has been the cause of a worldwide pandemic. The mental status of patients with COVID-19 who have been quarantined and…

Coronavirus disease 2019 in children: Characteristics, antimicrobial treatment, and outcomes.

Written by Hui Peng, Ping Gao, Qiong Xu, Maochang Liu, Jing Peng, Yang Wang, Hua Xu

J Clin Virol

May 7, 2020

BACKGROUND: At present, coronavirus disease 2019 (COVID-19) has spread in many countries. We conducted this study to help pediatricians understand the conditions of COVID-19 in children. METHODS: We retrospectively summarized…

Detection of Nucleocapsid Antibody to SARS-CoV-2 is More Sensitive than Antibody to Spike Protein in COVID-19 Patients

Written by Peter D Burbelo, Francis X Riedo, Chihiro Morishima, Stephen Rawlings, Davey Smith, Sanchita Das, Jeffrey R Strich, Daniel S Chertow, Richard T Davey Jr., Jeffrey I Cohen

April 24, 2020

BackgroundSARS-CoV-2, the cause of coronavirus disease 2019 (COVID-19), is associated with respiratory-related morbidity and mortality. Assays to detect virus-specific antibodies are important to understand the prevalence of infection and the…

The profile of peripheral blood lymphocyte subsets and serum cytokines in children with 2019 novel coronavirus pneumonia.

Comparative Study

J Infect

Written by Hui Li, Kailan Chen, Maochang Liu, Hua Xu, Qiong Xu

April 20, 2020

OBJECTIVES: The study was aimed at investigating the characteristics of peripheral blood lymphocyte subsets and serum cytokines in children with 2019 novel coronavirus (2019-nCoV) pneumonia. METHODS: Children with 2019-nCoV pneumonia…

Loopholes in Current Infection Control and Prevention Practices Against COVID-19 in Radiology Department and Improvement Suggestions.

Written by Juan Yu, Ning Ding, Huan Chen, Xia-Jing Liu, Zu-Hui Pu, Hua-Jian Xu, Yi Lei, Han-Wen Zhang

Can Assoc Radiol J

April 13, 2020

OBJECTIVES: To improve the infection control and prevention practices against coronavirus disease 2019 (COVID-19) in radiology department through loophole identification and providing rectifying measurements. METHODS: Retrospective analysis of 2 cases…

Infection Control against COVID-19 in Departments of Radiology.

Written by Juan Yu, Ning Ding, Huan Chen, Xia-Jing Liu, Wen-Jie He, Wei-Cai Dai, Zhao-Guang Zhou, Fan Lin, Zu-Hui Pu, Ding-Fu Li, Hua-Jian Xu, Yu-Li Wang, Han-Wen Zhang, Yi Lei

Acad Radiol

April 8, 2020

The COVID-19 epidemic, which is caused by the novel coronavirus SARS-CoV-2, has spread rapidly to become a world-wide pandemic. Chest radiography and chest CT are frequently used to support the…

Transmission and clinical characteristics of coronavirus disease 2019 in 104 outside-Wuhan patients, China

Written by Chengfeng Qiu, Qian Xiao, Xin Liao, Ziwei Deng, Huiwen Liu, Yuanlu Shu, Dinghui Zhou, Ye Deng, Hongqiang Wang, Xiang Zhao, Jianliang Zhou, Jin Wang, Zhihua Shi, Long Da

March 6, 2020

BackgroundCases with coronavirus disease 2019 (COVID-19) emigrated from Wuhan escalated the risk of spreading in other cities. This report focused on the outside-Wuhan patients to assess the transmission and clinical…

CT Imaging and Differential Diagnosis of COVID-19.

Written by Wei-Cai Dai, Han-Wen Zhang, Juan Yu, Hua-Jian Xu, Huan Chen, Si-Ping Luo, Hong Zhang, Li-Hong Liang, Xiao-Liu Wu, Yi Lei, Fan Lin

Can Assoc Radiol J

March 4, 2020

Since the beginning of 2020, coronavirus disease 2019 (COVID-19) has spread throughout China. This study explains the findings from lung computed tomography images of some patients with COVID-19 treated in…

Understanding and Promoting Racial Diversity in Healthcare Settings to Address Disparities in Pandemic Crisis Management.

Peer reviewed pubs

J Prim Care Community Health

Written by Azza Sarfraz, et al.

BACKGROUND: Health disparities have become apparent since the beginning of the COVID-19 pandemic. When observing racial discrimination in healthcare, self-reported incidences, and perceptions among minority groups in the United States…

Realizing Present and Future Promise of DIY Biology and Medicine through a Trust Architecture.

Written by Lisa M Rasmussen, Christi J Guerrini, Todd Kuiken, Camille Nebeker, Alex Pearlman, Sarah B Ware, Anna Wexler, Patricia J Zettler

Hastings Cent Rep

The speed and scale of the COVID-19 pandemic has highlighted the limits of current health systems and the potential promise of non-establishment research such as "DIY" research. We consider one…

[A retrospective analysis of medication in children with SARS-CoV-2 infection in Wuhan, China].

Zhongguo Dang Dai Er Ke Za Zhi

Written by Zhao-Song DU, Hua Xu, Mao-Chang Liu

OBJECTIVE: To study the medication in children with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in Wuhan, China, and to provide a reference for rational drug use in clinical…

Anosmia, Ageusia and COVID-19.

J Assoc Physicians India

Written by Partha S Ray

COVID-19 is certainly the greatest global health problem now and for the foreseeable future. Clinicians and scientists from all over the world have been producing evidence to understand the epidemiology,…

Aggravated Respiratory Failure From COVID-19 Infection: Patient Care Management From Nurses in the Intensive Care Unit.

Written by Jianying Xiong, Shanggan Zeng, Hua Xu, Ying Cao

Altern Ther Health Med

CONTEXT: About 19% of COVID-19-patients undergo hypoxic breathing problems, approximately 14% require intensive oxygen therapy, and 5% require mechanical ventilation and ICU admission. These patients can deteriorate rapidly, so nurses…

Coronavirus: indexed data speed up solutions.

Written by Lucila Ohno-Machado, Hua Xu

Nature

"Global Health": Time to Refocus while We still Have Time.

Written by David Bell, Eliah Aronoff-Spencer

Am J Trop Med Hyg

Two decades of growing resource availability from agencies and foundations in wealthy countries has transformed approaches to health in poorly resourced nations. This progress looks increasingly unstable as climate change,…

SARS-CoV-2 Variants of Concern.

Written by Jun Yong Choi, Davey M Smith

Yonsei Med J

Since the COVID-19 pandemic first began in December 2019, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus has continuously evolved with many variants emerging across the world. These variants…

Comparative efficacy of the front-line anti-HBV drugs in nucleos(t)ide analogue-naive chronic hepatitis B: A protocol for systematic review and network meta-analysis.

Written by Mao-Bing Chen, Hua Wang, Qi-Han Zheng, Wei-Yan Cui, Hua-Lan Xu, Xu-Wen Zheng

Medicine (Baltimore)

Evaluation of a Rapid Antigen Test for the Diagnosis of SARS-CoV-2 during the COVID-19 Pandemic.

Written by Chih-Chien Cheng, Chia-Chen Liu, Ting-Fang Chiu, Saint Shiou-Sheng Chen

Inquiry

OBJECTIVES: Reverse transcriptase-polymerase chain reaction (RT-PCR), the reference laboratory method of confirmed SARS-CoV-2 diagnosis, though requiring equipment, is time-consuming. There is a crucial demand for rapid techniques such as antigen…

In-service Education Programs for CT Technologists During the COVID-19 Pandemic.

Written by Sharon Mohammed, Lior Molvin

Radiol Technol

Engineering defensin α-helix to produce high-affinity SARS-CoV-2 spike protein binding ligands.

Written by Leonardo Antônio Fernandes, Anderson Albino Gomes, Beatriz Gomes Guimarães, Maria de Lourdes Borba Magalhães, Partha Ray, Gustavo Felippe da Silva

Protein Sci

The binding of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein to the angiotensin-converting enzyme 2 (ACE2) receptor expressed on the host cells is a critical initial step for…

[Analysis of clinical characteristics of patients with different vaccines and underlying diseases infected with novel coronavirus Omicron variant].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue

Written by Hua Xu, Jingjing Wang, Hongmei Gao, Yongqiang Wang

OBJECTIVE: To analyze the clinical characteristics of patients inoculated with different vaccines and underlying diseases, infected with the novel coronavirus Omicron variant. METHODS: The data of 430 patients infected with…

SARS-CoV-2 Omicron Variant of Concern: Everything You Wanted to Know about Omicron but Were Afraid to Ask.