RADx-rad / Diagnostics Portal

Related publications

Computational analysis of SARS-CoV-2/COVID-19 surveillance by wastewater-based epidemiology locally and globally: Feasibility, economy, opportunities and challenges.

August 15, 2020

With the economic and practical limits of medical screening for SARS-CoV-2/COVID-19 coming sharply into focus worldwide, scientists are turning now to wastewater-based epidemiology (WBE) as a potential tool for assessing…

Opportunities and limits of wastewater-based epidemiology for tracking global health and attainment of UN sustainable development goals.

Written by Sangeet Adhikari, Rolf U Halden

March 27, 2022

Wastewater-based epidemiology (WBE) emerged as a powerful, actionable health management tool during the COVID-19 pandemic. Hypothesizing future uses, we explored its potential for real-time, tracking of progress in attaining United…

Standardizing data reporting in the research community to enhance the utility of open data for SARS-CoV-2 wastewater surveillance.

Written by Jill S McClary-Gutierrez, Zachary T Aanderud, Mitham Al-Faliti, Claire Duvallet, Raul Gonzalez, Joe Guzman, Rochelle H Holm, Michael A Jahne, Rose S Kantor, Panagis Katsivelis, Katrin Gaardbo Kuhn, Laura M Langan, Cresten Mansfeldt, Sandra L McLellan, Lorelay M Mendoza Grijalva, Kevin S Murnane, Colleen C Naughton, Aaron I Packman, Sotirios Paraskevopoulos, Tyler S Radniecki, Fernando A Roman, Abhilasha Shrestha, Lauren B Stadler, Joshua A Steele, Brian M Swalla, Peter Vikesland, Brian Wartell, Carol J Wilusz, Judith Chui Ching Wong, Alexandria B Boehm, Rolf U Halden, Kyle Bibby, Jeseth Delgado Vela

SARS-CoV-2 RNA detection in wastewater is being rapidly developed and adopted as a public health monitoring tool worldwide. With wastewater surveillance programs being implemented across many different scales and by…

Comparison of high-frequency in-pipe SARS-CoV-2 wastewater-based surveillance to concurrent COVID-19 random clinical testing on a public U.S. university campus.

Written by Jillian Wright, Erin M Driver, Devin A Bowes, Bridger Johnston, Rolf U Halden

May 10, 2022

Wastewater-based epidemiology (WBE) is utilized globally as a tool for quantifying the amount of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) within communities, yet the efficacy of community-level wastewater monitoring…

A framework for wastewater sample collection from a sewage cleanout to inform building-scale wastewater-based epidemiology studies.

Written by Devin A Bowes, Erin M Driver, Rolf U Halden

April 30, 2022

Wastewater-based epidemiology (WBE) is a public health tool utilized for drug surveillance, and more recently, infectious disease monitoring of SARS-CoV-2. Sample collection is historically performed at a wastewater treatment plant,…

Occurrence of Z-drugs, benzodiazepines, and ketamine in wastewater in the United States and Mexico during the Covid-19 pandemic.

Written by Sangeet Adhikari, Rahul Kumar, Erin M Driver, Devin A Bowes, Keng Tiong Ng, Juan Eduardo Sosa-Hernandez, Mariel Araceli Oyervides-Muñoz, Elda M Melchor-Martínez, Manuel Martínez-Ruiz, Karina G Coronado-Apodaca, Ted Smith, Aruni Bhatnagar, Brian J Piper, Kenneth L McCall, Roberto Parra-Saldivar, Leon P Barron, Rolf U Halden

October 12, 2022

Z-drugs, benzodiazepines and ketamine are classes of psychotropic drugs prescribed for treating anxiety, sleep disorders and depression with known side effects including an elevated risk of addiction and substance misuse.…

Mass trends of parabens, triclocarban and triclosan in Arizona wastewater collected after the 2017 FDA ban on antimicrobials and during the COVID-19 pandemic.

Written by Sangeet Adhikari, Rahul Kumar, Erin M Driver, Tyler D Perleberg, Allan Yanez, Bridger Johnston, Rolf U Halden

July 23, 2022

Antimicrobials like parabens, triclosan (TCS), and triclocarban (TCC) are of public health concern worldwide due to their endocrine-disrupting properties and ability to promote antimicrobial drug resistance in human pathogens. The…

Systematic scoping review evaluating the potential of wastewater-based epidemiology for monitoring cardiovascular disease and cancer.

Written by Vivek Amin, Devin A Bowes, Rolf U Halden

February 1, 2023

Cardiovascular disease (CVD) and cancer are collectively responsible for tens of millions of global deaths each year. These rates are projected to intensify as the COVID-19 pandemic has caused delays…

Wastewater surveillance uncovers regional diversity and dynamics of SARS-CoV-2 variants across nine states in the USA.

Written by Rafaela S Fontenele, Yiyan Yang, Erin M Driver, Arjun Magge, Simona Kraberger, Joy M Custer, Keith Dufault-Thompson, Erin Cox, Melanie Engstrom Newell, Arvind Varsani, Rolf U Halden, Matthew Scotch, Xiaofang Jiang

March 16, 2023

Wastewater-based epidemiology (WBE) is a non-invasive and cost-effective approach for monitoring the spread of a pathogen within a community. WBE has been adopted as one of the methods to monitor…

Baseline Sequencing Surveillance of Public Clinical Testing, Hospitals, and Community Wastewater Reveals Rapid Emergence of SARS-CoV-2 Omicron Variant of Concern in Arizona, USA.

Written by Matthew F Smith, Steven C Holland, Mihyun B Lee, James C Hu, Nghia C Pham, Regan A Sullins, LaRinda A Holland, Tianchen Mu, Alexis W Thomas, Remington Fitch, Erin M Driver, Rolf U Halden, Michelle Villegas-Gold, Sheri Sanders, Jennifer L Krauss, Lora Nordstrom, Mary Mulrow, Michael White, Vel Murugan, Efrem S Lim

January 9, 2023

The adaptive evolution of SARS-CoV-2 variants is driven by selection for increased viral fitness in transmissibility and immune evasion. Understanding the dynamics of how an emergent variant sweeps across populations…

Considerations for Large Building Water Quality after Extended Stagnation.

Written by Caitlin R Proctor, William J Rhoads, Tim Keane, Maryam Salehi, Kerry Hamilton, Kelsey J Pieper, David M Cwiertny, Michele Prévost, Andrew J Whelton

June 16, 2020

The unprecedented number of building closures related to the coronavirus disease (COVID-19) pandemic is concerning because water stagnation will occur in many buildings that do not have water management plans…

SARS-CoV-2 in wastewater: State of the knowledge and research needs.

Written by Masaaki Kitajima, Warish Ahmed, Kyle Bibby, Annalaura Carducci, Charles P Gerba, Kerry A Hamilton, Eiji Haramoto, Joan B Rose

October 15, 2020

The ongoing global pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been a Public Health Emergency of International Concern, which was officially…

Detection of SARS-CoV-2 RNA in commercial passenger aircraft and cruise ship wastewater: a surveillance tool for assessing the presence of COVID-19 infected travellers.

Written by Warish Ahmed, Paul M Bertsch, Nicola Angel, Kyle Bibby, Aaron Bivins, Leanne Dierens, Janette Edson, John Ehret, Pradip Gyawali, Kerry A Hamilton, Ian Hosegood, Philip Hugenholtz, Guangming Jiang, Masaaki Kitajima, Homa T Sichani, Jiahua Shi, Katja M Shimko, Stuart L Simpson, Wendy J M Smith, Erin M Symonds, Kevin V Thomas, Rory Verhagen, Julian Zaugg, Jochen F Mueller

August 20, 2020

BACKGROUND: Wastewater-based epidemiology (WBE) for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can be an important source of information for coronavirus disease 2019 (COVID-19) management during and after the pandemic.…

Surveillance of SARS-CoV-2 RNA in wastewater: Methods optimisation and quality control are crucial for generating reliable public health information.

Written by Warish Ahmed, Aaron Bivins, Paul M Bertsch, Kyle Bibby, Phil M Choi, Kata Farkas, Pradip Gyawali, Kerry A Hamilton, Eiji Haramoto, Masaaki Kitajima, Stuart L Simpson, Sarmila Tandukar, Kevin Thomas, Jochen F Mueller

September 30, 2020

Monitoring for SARS-CoV-2 RNA in wastewater through the process of wastewater-based epidemiology (WBE) provides an additional surveillance tool, contributing to community-based screening and prevention efforts as these measurements have preceded…

Informing Building Strategies to Reduce Infectious Aerosol Transmission Risk by Integrating DNA Aerosol Tracers with Quantitative Microbial Risk Assessment.

Written by Nicholas Clements, Ilan Arvelo, Phil Arnold, Nicholas J Heredia, Ulrike W Hodges, Stan Deresinski, Peter W Cook, Kerry A Hamilton

March 31, 2023

Using aerosol-based tracers to estimate risk of infectious aerosol transmission aids in the design of buildings with adequate protection against aerosol transmissible pathogens, such as SARS-CoV-2 and influenza. We propose…

Wastewater Analysis of SARS CoV-2 in Tribal Communities