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Discovery and Characterization of Spike N-Terminal Domain-Binding Aptamers for Rapid SARS-CoV-2 Detection.

Written by Nataly Kacherovsky, Lucy F Yang, Ha V Dang, Emmeline L Cheng, Ian I Cardle, Alexandra C Walls, Matthew McCallum, Drew L Sellers, Frank DiMaio, Stephen J Salipante, Davide Corti, David Veesler, Suzie H Pun

September 20, 2021

The coronavirus disease 2019 (COVID-19) pandemic has devastated families and disrupted healthcare, economies and societies across the globe. Molecular recognition agents that are specific for distinct viral proteins are critical…

Inhibition of SARS-CoV-2 replication in the lung with siRNA/VIPER polyplexes.

Written by Domizia Baldassi, Shubhankar Ambike, Martin Feuerherd, Cho-Chin Cheng, David J Peeler, Daniel P Feldmann, Diana Leidy Porras-Gonzalez, Xin Wei, Lea-Adriana Keller, Nikolaus Kneidinger, Mircea Gabriel Stoleriu, Andreas Popp, Gerald Burgstaller, Suzie H Pun, Thomas Michler, Olivia M Merkel

March 29, 2022

SARS-CoV-2 has been the cause of a global pandemic since 2019 and remains a medical urgency. siRNA-based therapies are a promising strategy to fight viral infections. By targeting a specific…

Aptamer Sandwich Lateral Flow Assay (AptaFlow) for Antibody-Free SARS-CoV-2 Detection.

Written by Lucy F Yang, Nataly Kacherovsky, Nuttada Panpradist, Ruixuan Wan, Joey Liang, Bo Zhang, Stephen J Salipante, Barry R Lutz, Suzie H Pun

May 24, 2022

The COVID-19 pandemic is among the greatest health and socioeconomic crises in recent history. Although COVID-19 vaccines are being distributed, there remains a need for rapid testing to limit viral…

SCORe: SARS-CoV-2 Omicron Variant RBD-Binding DNA Aptamer for Multiplexed Rapid Detection and Pseudovirus Neutralization.

Written by Lucy F Yang, Nataly Kacherovsky, Joey Liang, Stephen J Salipante, Suzie H Pun

August 16, 2022

During the COVID-19 (coronavirus disease 2019) pandemic, several SARS-CoV-2 variants of concern emerged, including the Omicron variant, which has enhanced infectivity and immune invasion. Many antibodies and aptamers that bind…

Discordant SARS-CoV-2 Detection in the Nasopharynx Versus Trachea for Patients With Tracheostomies.

Written by Joshua D Smith, Jason A Correll, Jennifer L Stein, Robbi A Kupfer, Norman D Hogikyan, Robert J Morrison, Andrew P Stein

May 14, 2021

OBJECTIVES/HYPOTHESIS: Patients with tracheostomies have an anatomically altered connection between their upper and lower airways that could impact SARS-CoV-2 testing. Our goal was to evaluate for discordance in SARS-CoV-2 detection…

Postacute COVID-19 Laryngeal Injury and Dysfunction.

Written by Andrew J Neevel, Joshua D Smith, Robert J Morrison, Norman D Hogikyan, Robbi A Kupfer, Andrew P Stein

August 24, 2021

OBJECTIVE: Patients with COVID-19 are at risk for laryngeal injury and dysfunction secondary to respiratory failure, prolonged intubation, and other unique facets of this illness. Our goal is to report…

In-flight particulate matter concentrations in commercial flights are likely lower than other indoor environments.

Written by Jean C Rivera-Rios, Taekyu Joo, Masayuki Takeuchi, Thomas M Orlando, Tracy Bevington, John W Mathis, Cliffton D Pert, Brandon A Tyson, Tyler M Anderson-Lennert, Joshua A Smith, Nga Lee Ng

March 1, 2021

Air quality in indoor environments can have significant impacts on people's health, comfort, and productivity. Particulate matter (PM; also referred to as aerosols) is an important type of air pollutant,…

The Difficult Airway and Aerosol-Generating Procedures in COVID-19: Timeless Principles for Uncertain Times.

Written by Joshua D Smith, Michelle M Chen, Karthik Balakrishnan, Douglas R Sidell, Arianna di Stadio, Samuel A Schechtman, Robert M Brody, Robbi A Kupfer, Christopher H Rassekh, Michael J Brenner

June 23, 2020

The impact of the COVID-19 pandemic on otolaryngology practice is nowhere more evident than in acute airway management. Considerations of preventing SARS-CoV-2 transmission, conserving personal protective equipment, and prioritizing care…

Coronavirus Disease 2019 in Lung Transplant Recipients.

Written by Anna K Gergen, Helen J Madsen, Keval R Tilva, Joshua B Smith, Michael J Weyant

December 19, 2020

We report risk factors, clinical manifestations, and treatment course of 2 lung transplant recipients diagnosed with coronavirus disease 2019 (COVID-19) pneumonia. Both patients underwent an initial hospitalization and discharged home,…

ConceptWAS: A high-throughput method for early identification of COVID-19 presenting symptoms and characteristics from clinical notes.

Written by Juan Zhao, Monika E Grabowska, Vern Eric Kerchberger, Joshua C Smith, H Nur Eken, QiPing Feng, Josh F Peterson, S Trent Rosenbloom, Kevin B Johnson, Wei-Qi Wei

March 25, 2021

OBJECTIVE: Identifying symptoms and characteristics highly specific to coronavirus disease 2019 (COVID-19) would improve the clinical and public health response to this pandemic challenge. Here, we describe a high-throughput approach…

Coronavirus 2019 (COVID-19) venovenous extracorporeal oxygenation: Single community hospital results and insights.

Written by James Lee West, Andrew Nutting, Brock Daughtry, Andrew M Frey, Clara T Nicolas, Rayan Saab, David H Sibley, Joshua Smith, Ronald Roan, Michael Crain

April 19, 2022

BACKGROUND: The role of extracorporeal membrane oxygenation (ECMO) for patients with refractory respiratory failure due to coronavirus 2019 (COVID-19) is still unclear even now over a year into the pandemic.…

Examining Use and Effectiveness of Teletherapy for Patients with Dysphonia.

Written by Joshua D Smith, Katherine McConville, Margaret K Tiner, Elizabeth Ford Baldner, Marci Rosenberg, Robbi A Kupfer, Norman D Hogikyan, Robert J Morrison

February 28, 2023

OBJECTIVE(S)/HYPOTHESIS: Virtual therapy (teletherapy) for patients with dysphonia has become ubiquitous in the COVID-19 era. However, barriers to widespread implementation are evident, including unpredictable insurance coverage attributed to limited evidence…

Extracellular vesicle proteomics and phosphoproteomics identify pathways for increased risk in patients hospitalized with COVID-19 and type 2 diabetes mellitus.

Written by Yury O Nunez Lopez, Anton Iliuk, Anna Casu, Amay Parikh, Joshua S Smith, Karen Corbin, Daniel Lupu, Richard E Pratley

February 1, 2023

Recent studies suggest that extracellular vesicles (EVs) play a role in the pathogenesis of SARS-CoV-2 infection and the severity of COVID-19. However, their role in the interaction between COVID-19 and…

Comparison of COVID-19 Pandemic Waves in 10 Countries in Southern Africa, 2020-2021.

Written by Joshua Smith-Sreen, Bridget Miller, Alinune N Kabaghe, Evelyn Kim, Nellie Wadonda-Kabondo, Alean Frawley, Sarah Labuda, Eusébio Manuel, Helga Frietas, Anne C Mwale, Tebogo Segolodi, Pauline Harvey, Onalenna Seitio-Kgokgwe, Alfredo E Vergara, Eduardo S Gudo, Eric J Dziuban, Naemi Shoopala, Jonas Z Hines, Simon Agolory, Muzala Kapina, Nyambe Sinyange, Michael Melchior, Kelsey Mirkovic, Agnes Mahomva, Surbhi Modhi, Stephanie Salyer, Andrew S Azman, Catherine McLean, Lul P Riek, Fred Asiimwe, Michelle Adler, Sikhatele Mazibuko, Velephi Okello, Andrew F Auld

We used publicly available data to describe epidemiology, genomic surveillance, and public health and social measures from the first 3 COVID-19 pandemic waves in southern Africa during April 6, 2020-September…

Plasma therapy cured a COVID-19 patient with long duration of viral shedding for 49 days: The clinical features, laboratory tests, plasma therapy, and implications for public health management.

Written by Li Tan, Xia Kang, Bo Zhang, Shangen Zheng, Bo Liu, Tiantian Yu, Fan Yang, Qiongshu Wang, Hongming Miao

May 27, 2020

The structure-based design of peptidomimetic inhibitors against SARS-CoV-2 3C like protease as Potent anti-viral drug candidate.

Written by Hao Wang, Rongjuan Pei, Xin Li, Weilong Deng, Shuai Xing, Yanan Zhang, Chen Zhang, Shuai He, Hao Sun, Shuqi Xiao, Jin Xiong, Yecheng Zhang, Xinwen Chen, Yaxin Wang, Yu Guo, Bo Zhang, Luqing Shang

May 13, 2022

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), as the pathogen of coronavirus disease 2019 (COVID-19), has infected millions of people and took hundreds of thousands of lives. Unfortunately, there is…

Applying to Fellowship During a Pandemic: Lessons Learned From the 2020-2021 Orthopaedic Spine Fellowship Application Cycle.

Written by Meghana Jami, Amy L Xu, Bo Zhang, Wesley M Durand, Farah N Musharbash, Jacob M Babu

February 26, 2022

Introduction The COVID-19 pandemic resulted in a transition to a virtual format for all medical residency and fellowship application processes. Previous studies have discussed the successful implementation of virtual interviews,…

Associations of youth mental health, parental psychological distress, and family relationships during the COVID-19 outbreak in China.

Written by Yashuang Bai, Xiaohan Liu, Bo Zhang, Mingqi Fu, Ning Huang, Qitu Hu, Jing Guo

April 19, 2022

BACKGROUND: The COVID-19 pandemic has brought significant changes in society and family life, which could be particularly difficult for parents. The present study examines the relationship between youth mental health…

A cell-based large-scale screening of natural compounds for inhibitors of SARS-CoV-2.

Written by Zhe-Rui Zhang, Ya-Nan Zhang, Xiao-Dan Li, Hong-Qing Zhang, Shu-Qi Xiao, Fei Deng, Zhi-Ming Yuan, Han-Qing Ye, Bo Zhang

October 3, 2020

A non-RBM targeted RBD specific antibody neutralizes SARS-CoV-2 inducing S1 shedding.

Written by Yingyi Long, Shuyi Song, Feiyang Luo, Xiaojian Han, Chao Hu, Yingming Wang, Shenglong Li, Wang Wang, Huajun Zhang, Bo Zhang, Tingting Li, Aishun Jin

September 24, 2021

Potent neutralizing antibodies (Abs) have been proven with therapeutic efficacy for the intervention against SARS-CoV-2. Majority of these Abs function by directly interfering with the virus entry to host cells.…

Different pathogenesis of SARS-CoV-2 Omicron variant in wild-type laboratory mice and hamsters.

Written by Ya-Nan Zhang, Zhe-Rui Zhang, Hong-Qing Zhang, Na Li, Qiu-Yan Zhang, Xiao-Dan Li, Cheng-Lin Deng, Fei Deng, Shuo Shen, Bing Zhu, Bo Zhang

February 25, 2022

Pre-Clinical Development of a Potent Neutralizing Antibody MW3321 With Extensive SARS-CoV-2 Variants Coverage.

Written by Wen Jiang, Zherui Zhang, Yuhe Zhu, Ben Chen, Chunying Gu, Zhiyan Liu, Xukai Zhang, Hualong Xiong, Yanan Zhang, Bin Zheng, Rongjuan Wang, Shasha Jiao, An Wang, Tianying Zhang, Jinchao Zhang, Shuang Wang, Bo Zhang, Gang Li, Xun Gui

July 8, 2022

Since the outbreak of the coronavirus disease 2019 (COVID-19) pandemic, several variants of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have emerged and have consistently replaced the previous dominant…

Study on SARS-COV-2 transmission and the effects of control measures in China

Written by Bo Zhang, Hongwei Zhou, Fang Zhou

February 18, 2020

ObjectiveTo reconstruct the transmission trajectory of SARS-COV-2 and analyze the effects of control measures in China.

MethodsPython 3.7.1 was used to write a SEIR class to model the epidemic procedure…

Intranasal delivery of replicating mRNA encoding neutralizing antibody against SARS-CoV-2 infection in mice.

Written by Jia-Qi Li, Zhe-Rui Zhang, Hong-Qing Zhang, Ya-Nan Zhang, Xiang-Yue Zeng, Qiu-Yan Zhang, Cheng-Lin Deng, Xiao-Dan Li, Bo Zhang, Han-Qing Ye

October 25, 2021

The lung is the prophylaxis target against SARS-CoV-2 infection, and neutralizing antibodies are a leading class of biological products against various infectious viral pathogen. In this study, we develop a…

Prognostic Value of Pro-Inflammatory Neutrophils and C-Reactive Protein in Cancer Patient With Coronavirus Disease 2019: A Multi-Center, Retrospective Study.

Written by Bo Zhang, Yuanhang Yu, Shawna M Hubert, Yue Zhang, Jianhua Lu, Shihua Liu, Fang Xie, Liang Zhao, Xiao Lei, Wei Deng, Jianying Chen, Yunqiao Li

October 22, 2020

Background: At present, the epidemic of the novel coronavirus disease 2019 (COVID-19) has quickly engulfed the world. Inflammatory cytokines are associated with the severity and outcomes of patients with COVID-19.…

Comparing the Nucleocapsid Proteins of Human Coronaviruses: Structure, Immunoregulation, Vaccine, and Targeted Drug.

Written by Bo Zhang, Junjie Tian, Qintao Zhang, Yan Xie, Kejia Wang, Shuyi Qiu, Keyu Lu, Yang Liu

April 29, 2022

The seven pathogenic human coronaviruses (HCoVs) include HCoV-229E, HCoV-OC43, HCoV-NL63, and HCoV-HKU1, which usually cause mild upper respiratory tract diseases, and SARS-CoV, MERS-CoV, and SARS-CoV-2, which cause a severe acute…

Corrigendum to: Clinical and Epidemiological Features of 46 Children <1 Year Old With Coronavirus Disease 2019 in Wuhan, China: A Descriptive Study.

Written by Xinghua Liu, Jianqiao Tang, Rong Xie, Wei Li, Jianying Chen, Yan Guo, Bo Zhang, Yue Zhang, Juanjuan Wang, Cao Peng, Xiao Lei, Qunying Luo, Qiong Zhang, Yunqiao Li

February 13, 2021

Dynamic monitoring of immune function indexes in COVID-19 patients.

Written by Yaohui Song, Huixiu Zhong, Lin Li, Minggang Yin, Yi Yin, Xiaolong Guo, Bo Zhang, Weiping Liu

December 23, 2020

We conducted a retrospective analysis of the clinical characteristics and dynamic variations of immune indexes in nine COVID-19 patients in Zigong, China. We used flow cytometry and enzyme-linked immunosorbent assays…

Table_1_Psychological Health Issues of Medical Staff During the COVID-19 Outbreak.DOCX

Written by Jun Xie, Qi Liu, Xiaobing Jiang, Upasana Manandhar, Zhen Zhu, Yuanyuan Li, Bo Zhang

April 30, 2021

Background: The outbreak of novel coronavirus disease 2019 (COVID-19) has caused public panic and psychological health problems, especially in medical staff. We aimed to investigate the psychological effect of the…

Analysis of the real number of infected people by COVID-19: A system dynamics approach.

Written by Bo Hu, Matthias Dehmer, Frank Emmert-Streib, Bo Zhang

March 18, 2021

At the beginning of 2020, the COVID-19 pandemic was able to spread quickly in Wuhan and in the province of Hubei due to a lack of experience with this novel…

A new screening system for entry inhibitors based on cell-to-cell transmitted syncytia formation mediated by self-propagating hybrid VEEV-SARS-CoV-2 replicon.

Written by Na Li, Xiao-Ling Chen, Qi Li, Zhe-Rui Zhang, Cheng-Lin Deng, Bo Zhang, Xiao-Dan Li, Han-Qing Ye

The extremely high transmission rate of SARS-CoV-2 and severe cases of COVID-19 pose the two critical challenges in the battle against COVID-19. Increasing evidence has shown that the viral spike…

Chest CT Findings of Coronavirus Disease 2019 (COVID-19).

Written by Wu Cai, Junlin Yang, Guohua Fan, Liang Xu, Bo Zhang, Rong Liu

The aim of this study was to investigate the chest CT findings of coronavirus disease 2019 (COVID-19) from January to February 2020. CT features of six cases, confirmed by reverse…

Increased morbidity of obese mice infected with mouse-adapted SARS-CoV-2.

Written by Ya-Nan Zhang, Zhe-Rui Zhang, Hong-Qing Zhang, Xiao-Dan Li, Jia-Qi Li, Qiu-Yan Zhang, Jing Liu, Qi Li, Cheng-Lin Deng, Zheng-Li Shi, Zhi-Ming Yuan, Han-Qing Ye, Bo Zhang

August 25, 2021

Organ transplantation management in the midst of the COVID-19 outbreak: a synopsis.

Written by Bo-Han Zhang, Lyu-Nan Yan, Jia-Yin Yang

Clinical characteristics of 9 cancer patients with SARS-CoV-2 infection.

Written by Yong Zeng, Bo Zhang, Xufeng Zhang, Cunjian Yi

May 14, 2020

In December 2019, a cluster of pneumonia cases was caused by the Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) in Wuhan, China. Cancer patients are a special group, the immunity…

Detection of IgM and IgG antibodies in patients with coronavirus disease 2019.

Written by Hongyan Hou, Ting Wang, Bo Zhang, Ying Luo, Lie Mao, Feng Wang, Shiji Wu, Ziyong Sun

May 6, 2020

OBJECTIVES: This study aimed to determine the IgM and IgG responses against severe acute respiratory syndrome coronavirus (SARS-CoV)-2 in coronavirus disease 2019 (COVID-19) patients with varying illness severities. METHODS: IgM…

The Epidemic of Sexually Transmitted Diseases Under the Influence of COVID-19 in China.

Written by Xiangyu Yan, Xuechun Wang, Xiangyu Zhang, Lei Wang, Bo Zhang, Zhongwei Jia

December 16, 2021

Background: Prevention and control of HIV/AIDS and other sexually transmitted diseases (STDs) are major public health priorities in China, but are influenced by the COVID-19 epidemic. In this study, we…

Psychological Health Issues of Medical Staff During the COVID-19 Outbreak.

Written by Jun Xie, Qi Liu, Xiaobing Jiang, Upasana Manandhar, Zhen Zhu, Yuanyuan Li, Bo Zhang

April 30, 2021

Pentamidine Ninety Years on: the Development and Applications of Pentamidine and its Analogs.

Written by Bo Zhang, Yushan Jin, Lei Zhang, Hongshuang Wang, Xiaohui Wang

March 14, 2022

Pentamidine, an FDA-approved human drug for many protozoal infections, was initially synthesized in the late 1930s and first reported to be curative for parasitosis in the 1940s. After ninety years…

Intranasal administration of a recombinant RBD vaccine induced protective immunity against SARS-CoV-2 in mouse.

Written by Yingying Du, Yuhua Xu, Jin Feng, Longbo Hu, Yanan Zhang, Bo Zhang, Weili Guo, Runming Mai, Liyun Chen, Jianmin Fang, Hui Zhang, Tao Peng

April 15, 2021

The emergence of the global Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) pandemic underscores the importance of the rapid development of a non-invasive vaccine that can be easily administered. A vaccine…

Network analysis of COVID-19-related PTSD symptoms in China: the similarities and differences between the general population and PTSD sub-population.

Written by Fan Yang, Mingqi Fu, Ning Huang, Farooq Ahmed, Muhammad Shahid, Bo Zhang, Jing Guo, Paul Lodder

December 6, 2021

Background and Objectives: Prevalent Post-traumatic Stress Disorder (PTSD) negatively affected individuals during the COVID-19 pandemic. Using network analyses, this study explored the construct of PTSD symptoms during the COVID-19 pandemic…

ACE2-Targeting Monoclonal Antibody As A "Pan" Coronavirus Blocker In Vitro and In A Mouse Model

Written by Yuning Chen, Yanan Zhang, Renhong Yan, Guifeng Wang, Yuanyuan Zhang, Zherui Zhang, Yaning Li, jianxia ou, Wendi Chu, Zhijuan Liang, yongmei wang, Yili Chen, Ganjun Chen, Qi Wang, Qiang Zhou, Bo Zhang, Chunhe Wang

November 12, 2020

The evolution of coronaviruses, such as SARS-CoV-2, makes broad-spectrum coronavirus preventional or therapeutical strategies highly sought after. Here we report a human angiotensin-converting enzyme 2 (ACE2)-targeting monoclonal antibody, 3E8, blocked…

Characteristics and Outcomes of 35 Breast Cancer Patients Infected With COVID-19.

Written by Bo Zhang, Rong Xie, Shawna M Hubert, Yuanhang Yu, Yue Zhang, Xiao Lei, Wei Deng, Jianying Chen, Yunqiao Li

October 21, 2020

Since December 2019, a novel coronavirus disease (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has rapidly engulfed the world. Cancer patients infected with COVID-19 are considered to…

Worldwide Research Trends on Artemisinin: A Bibliometric Analysis From 2000 to 2021.

Written by Yankai Dong, Lina Liu, Jie Han, Lianqing Zhang, Yi Wang, Juan Li, Yuexiang Li, He Liu, Kun Zhou, Luyao Li, Xin Wang, Xue Shen, Meiling Zhang, Bo Zhang, Xiaofei Hu

May 6, 2022

Objective: Artemisinin is an organic compound that comes from Artemisia annua. Artemisinin treatment is the most important and effective method for treating malaria. Bibliometric analysis was carried out to identify…

Cost-effectiveness analysis on COVID-19 surveillance strategy of large-scale sports competition.

Written by Xuechun Wang, Yiru Cai, Bo Zhang, Xiangyu Zhang, Lianhao Wang, Xiangyu Yan, Mingchen Zhao, Yuan Zhang, Zhongwei Jia

March 18, 2022

BACKGROUND: Nucleic acid test (NAT) could effectively control the spread of COVID-19 caused by large-scale sports competitions. However, quantitative analysis on the appropriate frequency of NAT is scarce, and the…

Aglycone polyether ionophores as broad-spectrum agents inhibit multiple enveloped viruses including SARS-CoV-2 in vitro and successfully cure JEV infected mice

Written by Tiangang Liu, Jia-Qi Li, Minjian Huang, Ya-Nan Zhang, Ran Liu, Zhe-Rui Zhang, Qiu-Yan Zhang, Yong Wang, Jing Liu, Zixin Deng, Bo Zhang, Han-Qing Ye

October 28, 2020

Infections with zoonotic viruses, such as flaviviruses, influenza virus, and the SARS-CoV-2 pandemic coronavirus constitute an increasing global risk. Hence, an urgent need exists for the development of broad-spectrum antivirals…

Effect of the COVID-19 Pandemic on the Orthopaedic Surgery Residency Application Process: What Can We Learn?

Written by Kevin Y Wang, Jacob Babu, Bo Zhang, Meghana Jami, Farah Musharbash, Dawn LaPorte

October 4, 2021

INTRODUCTION: The goal of this study was to assess the influence of the coronavirus disease 2019 pandemic on the orthopaedic surgery residency application process in the 2020 to 2021 application…

Data_Sheet_1_The Epidemic of Sexually Transmitted Diseases Under the Influence of COVID-19 in China.DOCX

Written by Xiangyu Yan, Xuechun Wang, Xiangyu Zhang, Lei Wang, Bo Zhang, Zhongwei Jia

December 16, 2021

The Intentions to Wear Face Masks and the Differences in Preventive Behaviors between Urban and Rural Areas during COVID-19: An Analysis Based on the Technology Acceptance Model.

Written by Bo Zhang, Zhongjie Li, Lei Jiang

September 23, 2021

The SARS-CoV-2 virus first emerged in late 2019 and has since spread quickly throughout China and become a global pandemic. As the situation with COVID-19 has evolved, wearing a face…

Characteristics of Household Transmission of COVID-19.

Written by Wei Li, Bo Zhang, Jianhua Lu, Shihua Liu, Zhiqiang Chang, Cao Peng, Xinghua Liu, Peng Zhang, Yan Ling, Kaixiong Tao, Jianying Chen

November 5, 2020

BACKGROUND: Since December 2019, SARS-CoV-2 has extended to most parts of China with >80 000 cases and to at least 100 countries with >60 000 international cases as of 15…

Urinary trace elements in association with disease severity and outcome in patients with COVID-19.

Written by Hao-Long Zeng, Bo Zhang, Xu Wang, Qing Yang, Liming Cheng

December 30, 2020

BACKGROUND: The dynamics of urinary trace elements in patients with COVID-19 still remains to be investigated. METHODS: A retrospective study was performed on a cohort of 138 confirmed COVID-19 patients…

Structural characterization of cocktail-like targeting polysaccharides from Ecklonia kurome Okam and their anti-SARS-CoV-2 activities in vitro

Written by Kan Ding, Bo Zhang, Xinwen Chen, Yechun Xu, Chunfan Huang, Can Jin, Zhenyun Du, Xia Chen, Yaqi Ding, Hao Sun, Meixia Li, Rongjuan Pei, Shihai Zhang, Minbo Su, Yi Zhang, Jia Li

January 15, 2021

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the etiological agent responsible for the worldwide coronavirus disease 2019 (COVID-19) outbreak. Investigation has confirmed that polysaccharide heparan sulfate can bind to…

Comparison of the Efficacy and Safety of PARP Inhibitors as a Monotherapy for Platinum-Sensitive Recurrent Ovarian Cancer: A Network Meta-Analysis.

Written by Hongmei Wang, Meng Wu, Haonan Liu, Hang Zhou, Yang Zhao, Yifan Geng, Bo Jiang, Kai Zhang, Bo Zhang, Zhengxiang Han, Xiuping Du

November 24, 2021

BACKGROUND: The present COVID-19 pandemic has tended toward normality. To provide convenient, safe, and effective home treatment programs for patients with recurrent ovarian cancer (ROC), the clinical efficacy and safety…

Clinical and Epidemiological Features of 46 Children <1 Year Old With Coronavirus Disease 2019 in Wuhan, China: A Descriptive Study.

Written by Xinghua Liu, Jianqiao Tang, Rong Xie, Wei Li, Jianying Chen, Yan Guo, Bo Zhang, Yue Zhang, Juanjuan Wang, Cao Peng, Xiao Lei, Qunying Luo, Qiong Zhang, Yunqiao Li

September 14, 2020

The number of coronavirus disease 2019 (COVID-19) cases has exceeded 10 million. However, little is known about the epidemiology and clinical characteristics of COVID-19 infants. We collected medical information of…

Expert Consensus on Telemedicine Management of Diabetes (2020 Edition).

Written by Bo Zhang

March 24, 2021

Diabetes is a chronic disease that is very suitable for telemedicine management. Owing to the coronavirus disease 2019 (COVID-19) pandemic, telemedicine management of diabetes is particularly important. This consensus proposes…

Differences and prediction of imaging characteristics of COVID-19 and non-COVID-19 viral pneumonia: A multicenter study.

Written by Bo Zhang, Xia Wang, Xiaoyan Tian, Xiaoying Zhao, Bin Liu, Xingwang Wu, Yaqing Du, Guoquan Huang, Qing Zhang

October 16, 2020

To study the differences in imaging characteristics and prediction of COVID-19 and non-COVID-19 viral pneumonia through chest CT.Chest CT data of 128 cases of COVID-19 and 47 cases of non-COVID-19…

A Short Plus Long-Amplicon Based Sequencing Approach Improves Genomic Coverage and Variant Detection In the SARS-CoV-2 Genome

Written by Carlos Arana, Chaoying Liang, Matthew Brock, Bo Zhang, Jinchun Zhou, Li Chen, Brandi Cantarel, Jeffrey SoRelle, Lora V. Hooper, Prithvi Raj

June 20, 2021

High viral transmission in the COVID-19 pandemic has enabled SARS-CoV-2 to acquire new mutations that impact genome sequencing methods. The ARTIC.v3 primer pool that amplifies short amplicons in a multiplex-PCR…

Bergamottin, a bioactive component of bergamot, inhibits SARS-CoV-2 infection in golden Syrian hamsters.

Written by Minmin Zhou, Yang Liu, Junyuan Cao, Siqi Dong, Yuxia Hou, Yan Yu, Qiuyan Zhang, Yueli Zhang, Xiaoying Jia, Bo Zhang, Gengfu Xiao, Gang Li, Wei Wang

June 19, 2022

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has caused an ongoing pandemic, coronavirus disease-2019 (COVID-19), which has become a major global public health event. Antiviral compounds remain the predominant means of…

Baicalein inhibits SARS-CoV-2/VSV replication with interfering mitochondrial oxidative phosphorylation in a mPTP dependent manner.

Written by Shichao Huang, Yu'e Liu, Yanan Zhang, Ru Zhang, ChengJie Zhu, Lihong Fan, Gang Pei, Bo Zhang, Yufeng Shi

November 13, 2020

Novel pectin from crude polysaccharide of Syzygium aromaticum against SARS-CoV-2 activities by targeting 3CLpro

Written by Can Jin, Bo Feng, Rong juan Pei, Ya qi Ding, Mei xia Li, Xia Chen, Zhen yun Du, Yang xiao Ding, Chun fan Huang, Bo Zhang, Xin wen Chen, Yi Zang, Jia Li, Kan Ding

October 29, 2021

To date, COVID-19 is still a severe threat to public health, hence specific effective therapeutic drugs development against SARS-CoV-2 is urgent needed. 3CLpro and PLpro and RdRp are the enzymes…

Decreased TMPRSS2 expression by SARS-CoV-2 predicts the poor prognosis of lung cancer patients through metabolic pathways and immune infiltration.

Written by Xiaopeng Liu, Bing Liu, Yanan Shang, Pengxiu Cao, Jiajie Hou, Fei Chen, Bo Zhang, Yumei Fan, Ke Tan

January 11, 2022

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has rapidly spread around the world and became a global pandemic in 2020. One promising drug target for SARS-CoV-2 is the transmembrane protease…

Micronucleus production, activation of DNA damage response and cGAS-STING signaling in syncytia induced by SARS-CoV-2 infection.

Written by He Ren, Chaobing Ma, Haoran Peng, Bo Zhang, Lulin Zhou, Yan Su, Xiaoyan Gao, Hongyan Huang

October 21, 2021

SARS-CoV-2 infection could cause severe acute respiratory syndrome, largely attributed to dysregulated immune activation and extensive lung tissue damage. However, the underlying mechanisms are not fully understood. Here, we reported…

A special case of COVID-19 with long duration of viral shedding for 49 days

Written by Li Tan, Xia Kang, Bo Zhang, Shangen Zheng, Bo Liu, Tiantian Yu, Fan Yang, Qiongshu Wang, Hongming Miao

March 27, 2020

Prolonged viral shedding is associated with severe status and poor prognosis of COVID-19 patients. Unexpectedly, here we report a non-severe patient with the longest duration of viral shedding. According to…

The endogenous factors affecting the detection of serum SARS-CoV-2 IgG/IgM antibodies by ELISA.

Written by Weiping Liu, Xia Long, Kexing Wan, Minggang Yin, Yi Yin, Bo Zhang, Lin Li, Yaohui Song

January 7, 2022

To investigate endogenous interference factors of the detection results of novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) IgM/IgG. Enzyme-linked immunosorbent assay (ELISA) was used to detect SARS-CoV-2 IgM/IgG in…

Study on SARS-CoV-2 transmission and the effects of control measures in China.

Written by Bo Zhang, Hongwei Zhou, Fang Zhou

November 30, 2020

OBJECTIVE: To reconstruct the transmission trajectory of SARS-CoV-2 and analyze the effects of control measures in China. METHODS: Python 3.7.1 was used to write a SEIR class to model the…

Is the psychological impact of exposure to COVID-19 stronger in adolescents with pre-pandemic maltreatment experiences? A survey of rural Chinese adolescents.

Written by Jing Guo, Mingqi Fu, Danxia Liu, Bo Zhang, Xiaohua Wang, Marinus H van IJzendoorn

August 20, 2020

BACKGROUND: Since the COVID-19 outbreak at the end of 2019, it has evolved into a global pandemic with tremendous mental health impact besides the threats to people's physical health. OBJECTIVE:…

Berbamine hydrochloride potently inhibits SARS-CoV-2 infection by blocking S protein-mediated membrane fusion.

Written by Zhe-Rui Zhang, Ya-Nan Zhang, Hong-Qing Zhang, Qiu-Yan Zhang, Na Li, Qi Li, Cheng-Lin Deng, Bo Zhang, Xiao-Dan Li, Han-Qing Ye

April 25, 2022

COVID-19 caused by SARS-CoV-2 has posed a significant threat to global public health since its outbreak in late 2019. Although there are a few drugs approved for clinical treatment to…

[Mechanism of Xuanfei Baidu Tang in treatment of COVID-19 based on network pharmacology].

Written by Yi Wang, Xiang Li, Jun-Hua Zhang, Rui Xue, Jing-Yang Qian, Xiao-Hui Zhang, Han Zhang, Qing-Quan Liu, Xiao-Hui Fan, Yi-Yu Cheng, Bo-Li Zhang

The study aimed to investigate the multi-constituent, multi-target mechanism of Xuanfei Baidu Tang(XFBD) in the treatment of coronavirus disease 2019(COVID-19), through exploring the main ingredients and effective targets of XFBD,…

SARS-CoV-2 replicon for high-throughput antiviral screening.

Written by Qiu-Yan Zhang, Cheng-Lin Deng, Jing Liu, Jia-Qi Li, Hong-Qing Zhang, Na Li, Ya-Nan Zhang, Xiao-Dan Li, Bo Zhang, Yi Xu, Han-Qing Ye

The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) virus, which is highly pathogenic and classified as a biosafety level 3 (BSL-3) agent, has greatly threatened global health and efficacious antivirals are…

ACE2-Targeting antibody suppresses SARS-CoV-2 Omicron and Delta variants.

Written by Jianxia Ou, Yanan Zhang, Yongmei Wang, Zherui Zhang, Hongping Wei, Junping Yu, Qi Wang, Guifeng Wang, Bo Zhang, Chunhe Wang

February 9, 2022

Refocus attention on HIV/AIDS: it was neglected during the COVID-19 pandemic.

Written by Xiangyu Yan, Xuechun Wang, Lei Wang, Bo Zhang, Zhongwei Jia

June 18, 2022

Safety profile of the antiviral drug remdesivir: An update.

Written by Qianqian Fan, Bo Zhang, Jie Ma, Shuyang Zhang

July 22, 2020

Exploring the Bridge Cases' Role in the Transmission of the SARS-CoV-2 Delta Variant - Ruili City, Yunnan Province, China, July-September 2021.

Written by Xiangyu Yan, Litao Chang, Zekun Wang, Linhui Hao, Zhongwei Jia, Bo Zhang, Tiejun Shui

December 3, 2021

WHAT IS ALREADY KNOWN ABOUT THIS TOPIC?: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Delta variant has proved to have increased transmissibility, and mutations that can cause partial immune…

Number of Healthcare Workers Who Have Died of COVID-19.

Written by Bo Zhang, Dylan S Small

[Recent advances in treatment of viral pneumonia using Chinese patent medicine].

Written by Tao Wang, Li-Feng Han, Yue-Fei Wang, Lin Miao, Jian Yang, Jun-Hua Zhang, Xiu-Mei Gao, Bo-Li Zhang

Viral pneumonia is caused by a spreading of lung infection caused by respiratory viruses. Some virus infections were found to be highly aggressive, leading to lung inflammation and severe damage…

The dynamics of immune response in COVID-19 patients with different illness severity.

Written by Bo Zhang, Daoyuan Yue, Yun Wang, Feng Wang, Shiji Wu, Hongyan Hou

October 10, 2020

This study aimed to analyze the dynamic changes of lymphocyte subsets and specific antibodies in coronavirus disease 2019 (COVID-19) patients with different illness severity. The amounts of lymphocyte subsets and…

Targeting epigenetic regulators for inflammation: Mechanisms and intervention therapy.

Written by Su Zhang, Yang Meng, Lian Zhou, Lei Qiu, Heping Wang, Dan Su, Bo Zhang, Kui-Ming Chan, Junhong Han

September 15, 2022

Emerging evidence indicates that resolution of inflammation is a critical and dynamic endogenous process for host tissues defending against external invasive pathogens or internal tissue injury. It has long been…

SARS-CoV-2 Nucleocapsid Protein Has DNA-Melting and Strand-Annealing Activities With Different Properties From SARS-CoV-2 Nsp13.

Written by Bo Zhang, Yan Xie, Zhaoling Lan, Dayu Li, Junjie Tian, Qintao Zhang, Hongji Tian, Jiali Yang, Xinnan Zhou, Shuyi Qiu, Keyu Lu, Yang Liu

July 22, 2022

Since December 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread throughout the world and has had a devastating impact on health and economy. The biochemical characterization of SARS-CoV-2…

Relationship among Child Maltreatment, Parental Conflict, and Mental Health of Children during the COVID-19 Lockdown in China.

Written by Yashuang Bai, Mingqi Fu, Xiaohua Wang, Danxia Liu, Yanjun Zhang, Chengbin Liu, Bo Zhang, Jing Guo

August 26, 2022

Children are more likely to experience maltreatment and parental conflict in a pandemic context, which can exacerbate their vulnerability to psychological disorders. The purpose of the present study was to…

Epidemiological and clinical characteristics of the largest COVID-19 outbreak along the China-Myanmar border in Ruili City, Yunnan Province, China.

Written by Xiangyu Yan, Linhui Hao, Zekun Wang, Xuechun Wang, Xiangyu Zhang, Tao Li, Zhongwei Jia, Litao Chang, Bo Zhang, Tiejun Shui

August 23, 2022

Background: Imported COVID-19 patients posed great challenges to border areas' COVID-19 control. However, research was scarce to reveal epidemiological characteristics of COVID-19 in border areas. This study aimed to explore…

Touchscreen-compatible, Real-Time Electrochemical Sensing of SARS-CoV-2