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SCENTinel: A Rapid Smell Test for COVID-19 Surveillance

Monell Chemical Senses Center

Pamela Dalton

Chemosensory Testing
Website

Related publications

SCENTinel 1.0: Development of a Rapid Test to Screen for Smell Loss.

Written by Valentina Parma, Mackenzie E Hannum, Maureen O'Leary, Robert Pellegrino, Nancy E Rawson, Danielle R Reed, Pamela H Dalton
January 1, 2021

Commercially available smell tests are primarily used in research or in-depth clinical evaluations and are too costly and time-consuming for population surveillance in health emergencies like COVID-19. To address this…

More than just smell - COVID-19 is associated with severe impairment of smell, taste, and chemesthesis

Written by Valentina Parma, Kathrin Ohla, Maria G. Veldhuizen, Masha Y. Niv, Christine E. Kelly, Alyssa J. Bakke, Keiland W. Cooper, Cédric Bouysset, Nicola Pirastu, Michele Dibattista, Rishemjit Kaur, Marco Tullio Liuzza, Marta Y. Pepino, Veronika Schöpf, Veronica Pereda-Loth, Shannon B Olsson, Richard C Gerkin, Paloma Rohlfs Domínguez, Javier Albayay, Michael C. Farruggia, Surabhi Bhutani, Alexander W Fjaeldstad, Ritesh Kumar, Anna Menini, Moustafa Bensafi, Mari Sandell, Iordanis Konstantinidis, Antonella Di Pizio, Federica Genovese, Lina Öztürk, Thierry Thomas-Danguin, Johannes Frasnelli, Sanne Boesveldt, Özlem Saatci, Luis R. Saraiva, Cailu Lin, Jérôme Golebiowski, Liang-Dar Hwang, Mehmet Hakan Ozdener, Maria Dolors Guàrdia, Christophe Laudamiel, Marina Ritchie, Jan Havlícek, Denis Pierron, Eugeni Roura, Marta Navarro, Alissa A. Nolden, Juyun Lim, KL Whitcroft, Lauren R. Colquitt, Camille Ferdenzi, Evelyn V. Brindha, Aytug Altundag, Alberto Macchi, Alexia Nunez-Parra, Zara M. Patel, Sébastien Fiorucci, Carl M. Philpott, Barry C. Smith, Johan N Lundström, Carla Mucignat, Jane K. Parker, Mirjam van den Brink, Michael Schmuker, Florian Ph.S Fischmeister, Thomas Heinbockel, Vonnie D.C. Shields, Farhoud Faraji, Enrique Enrique Santamaría, William E.A. Fredborg, Gabriella Morini, Jonas K. Olofsson, Maryam Jalessi, Noam Karni, Anna D'Errico, Rafieh Alizadeh, Robert Pellegrino, Pablo Meyer, Caroline Huart, Ben Chen, Graciela M. Soler, Mohammed K. Alwashahi, Olagunju Abdulrahman, Antje Welge-Lüssen, Pamela Dalton, Jessica Freiherr, Carol H. Yan, Jasper H. B. de Groot, Vera V. Voznessenskaya, Hadar Klein, Jingguo Chen, Masako Okamoto, Elizabeth A. Sell, Preet Bano Singh, Julie Walsh-Messinger, Nicholas S. Archer, Sachiko Koyama, Vincent Deary, S. Craig Roberts, Hüseyin Yanik, Samet Albayrak, Lenka Martinec Novákov, Ilja Croijmans, Patricia Portillo Mazal, Shima T. Moein, Eitan Margulis, Coralie Mignot, Sajidxa Mariño, Dejan Georgiev, Pavan K. Kaushik, Bettina Malnic, Hong Wang, Shima Seyed-Allaei, Nur Yoluk, Sara Razzaghi, Jeb M. Justice, Diego Restrepo, Julien W Hsieh, Danielle R. Reed, Thomas Hummel, Steven D Munger, John E Hayes
May 8, 2020

Recent anecdotal and scientific reports have provided evidence of a link between COVID-19 and chemosensory impairments such as anosmia. However, these reports have downplayed or failed to distinguish potential effects…

Proof-of-concept: SCENTinel 1.1 rapidly discriminates COVID-19-related olfactory disorders.

Written by Stephanie R Hunter, Mackenzie E Hannum, Robert Pellegrino, Maureen A O'Leary, Nancy E Rawson, Danielle R Reed, Pamela H Dalton, Valentina Parma
January 1, 2023

It is estimated that 20%-67% of those with COVID-19 develop olfactory disorders, depending on the SARS-CoV-2 variant. However, there is an absence of quick, population-wide olfactory tests to screen for…

Corona Viruses and the Chemical Senses: Past, Present, and Future.

Written by Robert Pellegrino, Keiland W Cooper, Antonella Di Pizio, Paule V Joseph, Surabhi Bhutani, Valentina Parma
May 14, 2020

A wealth of rapidly evolving reports suggests that olfaction and taste disturbances may be manifestations of the novel COVID-19 pandemic. While otolaryngological societies worldwide have started to consider chemosensory evaluation…

Recent smell loss is the best predictor of COVID-19: a preregistered, cross-sectional study

Written by Richard C. Gerkin, Kathrin Ohla, Maria Geraldine Veldhuizen, Paule V. Joseph, Christine E. Kelly, Alyssa J. Bakke, Kimberley E. Steele, Michael C. Farruggia, Robert Pellegrino, Marta Y. Pepino, Cédric Bouysset, Graciela M. Soler, Veronica Pereda-Loth, Michele Dibattista, Keiland W. Cooper, Ilja Croijmans, Antonella Di Pizio, M. Hakan Ozdener, Alexander W. Fjaeldstad, Cailu Lin, Mari A. Sandell, Preet B. Singh, V. Evelyn Brindha, Shannon B. Olsson, Luis R. Saraiva, Gaurav Ahuja, Mohammed K. Alwashahi, Surabhi Bhutani, Anna D'Errico, Marco A. Fornazieri, Jérôme Golebiowski, Liang-Dar Hwang, Lina Öztürk, Eugeni Roura, Sara Spinelli, Katherine L. Whitcroft, Farhoud Faraji, Florian Ph.S Fischmeister, Thomas Heinbockel, Julien W. Hsieh, Caroline Huart, Iordanis Konstantinidis, Anna Menini, Gabriella Morini, Jonas K. Olofsson, Carl M. Philpott, Denis Pierron, Vonnie D. C. Shields, Vera V. Voznessenskaya, Javier Albayay, Aytug Altundag, Moustafa Bensafi, María Adelaida Bock, Orietta Calcinoni, William Fredborg, Christophe Laudamiel, Juyun Lim, Johan N. Lundström, Alberto Macchi, Pablo Meyer, Shima T. Moein, Enrique Santamaría, Debarka Sengupta, Paloma Paloma Domínguez, Hüseyin Yanık, Sanne Boesveldt, Jasper H. B. de Groot, Caterina Dinnella, Jessica Freiherr, Tatiana Laktionova, Sajidxa Mariño, Erminio Monteleone, Alexia Nunez-Parra, Olagunju Abdulrahman, Marina Ritchie, Thierry Thomas-Danguin, Julie Walsh-Messinger, Rashid Al Abri, Rafieh Alizadeh, Emmanuelle Bignon, Elena Cantone, Maria Paola Cecchini, Jingguo Chen, Maria Dolors Guàrdia, Kara C. Hoover, Noam Karni, Marta Navarro, Alissa A. Nolden, Patricia Portillo Mazal, Nicholas R. Rowan, Atiye Sarabi-Jamab, Nicholas S. Archer, Ben Chen, Elizabeth A. Di Valerio, Emma L. Feeney, Johannes Frasnelli, Mackenzie Hannum, Claire Hopkins, Hadar Klein, Coralie Mignot, Carla Mucignat, Yuping Ning, Elif E. Ozturk, Mei Peng, Ozlem Saatci, Elizabeth A. Sell, Carol H. Yan, Raul Alfaro, Cinzia Cecchetto, Gérard Coureaud, Riley D. Herriman, Jeb M. Justice, Pavan Kumar Kaushik, Sachiko Koyama, Jonathan B. Overdevest, Nicola Pirastu, Vicente A. Ramirez, S. Craig Roberts, Barry C. Smith, Hongyuan Cao, Hong Wang, Patrick Balungwe, Marius Baguma, Thomas Hummel, John E. Hayes, Danielle R. Reed, Masha Y. Niv, Steven D. Munger, Valentina Parma
July 26, 2020

BackgroundCOVID-19 has heterogeneous manifestations, though one of the most common symptoms is a sudden loss of smell (anosmia or hyposmia). We investigated whether olfactory loss is a reliable predictor of…

Assessing the extent and timing of chemosensory impairments during COVID-19 pandemic.

Written by Cinzia Cecchetto, Antonella Di Pizio, Federica Genovese, Orietta Calcinoni, Alberto Macchi, Andreas Dunkel, Kathrin Ohla, Sara Spinelli, Michael C Farruggia, Paule V Joseph, Anna Menini, Elena Cantone, Caterina Dinnella, Maria Paola Cecchini, Anna D'Errico, Carla Mucignat-Caretta, Valentina Parma, Michele Dibattista
September 1, 2021

Chemosensory impairments have been established as a specific indicator of COVID-19. They affect most patients and may persist long past the resolution of respiratory symptoms, representing an unprecedented medical challenge.…

From loss to recovery: how to effectively assess chemosensory impairments during COVID-19 pandemic

Written by Cinzia Cecchetto, Antonella Di Pizio, Federica Genovese, Orietta Calcinoni, Alberto Macchi, Andreas Dunkel, Kathrin Ohla, Sara Spinelli, Michael C. Farruggia, Paule V. Joseph, Anna Menini, Elena Cantone, Caterina Dinnella, Maria Paola Cecchini, Anna D'Errico, Carla Mucignat-Caretta, Valentina Parma, Michele Dibattista
March 26, 2021

Chemosensory impairments have been established as a specific indicator of COVID-19. They affect most patients and may persist long past the resolution of respiratory symptoms, representing an unprecedented medical challenge.…

Leveraging machine learning and self-administered tests to predict COVID-19:An olfactory and gustatory dysfunction assessment through crowd-sourced data in India

Written by Ritesh Kumar, Maneet Singh, Prateek Singh, Valentina Parma, Kathrin Ohla, Shannon B Olsson, Varun Saini, Jyotsna Rani, Kunal Kishore, Priyanka Kumari, Parul Ichhpujani, Anupma Sharma, Saurav Kumar, Manu Sharma, Amol P Bhondekar, Anamika Kothari, Viren Sardana, Sudarshan Iyengar, Debasis Dash, Rishemjit Kaur
October 26, 2021

It has been established that smell and taste loss are frequent symptoms during COVID-19 onset. Most evidence stems from medical exams or self-reports. The latter is particularly confounded by the…

The Effects of Persistent Olfactory and Gustatory Dysfunctions on Quality of Life in Long-COVID-19 Patients.

Written by Luigi Angelo Vaira, Claudia Gessa, Giovanna Deiana, Giovanni Salzano, Fabio Maglitto, Jerome R Lechien, Sven Saussez, Pasquale Piombino, Andrea Biglio, Federico Biglioli, Paolo Boscolo-Rizzo, Claire Hopkins, Valentina Parma, Giacomo De Riu
January 19, 2022

(1) Background: Persistent olfactory (POD) and gustatory (PGD) dysfunctions are one of the most frequent symptoms of long-Coronavirus Disease 2019 but their effect on the quality of life (QoL) of…

COVID-19 Related Chemosensory Changes in Individuals with Self-Reported Obesity

Written by Surabhi Bhutani, Geraldine Coppin, Maria Geraldine Veldhuizen, Valentina Parma, Paule Valery Joseph
March 2, 2021

Background/objectivesIndividuals with obesity show alterations in smell and taste abilities. Smell and taste loss are also the most prominent neurological symptoms of COVID-19, yet how chemosensory ability present in individuals…

SCENTinel 1.1 rapidly screens for COVID-19 related olfactory disorders

Written by Stephanie R Hunter, Mackenzie E Hannum, Robert Pellegrino, Maureen A O'Leary, Nancy E Rawson, Danielle R Reed, Pamela H Dalton, Valentina Parma
March 23, 2022

The COVID-19 pandemic has increased the prevalence of people suffering from olfactory disorders. In the absence of quick, population-wide olfactory tests, we developed SCENTinel, a rapid, inexpensive smell test to…

Increasing incidence of parosmia and phantosmia in patients recovering from COVID-19 smell loss

Written by Kathrin Ohla, Maria G Veldhuizen, Tomer Green, Mackenzie E Hannum, Alyssa J Bakke, Shima Moein, Arnaud Tognetti, Elbrich M Postma, Robert Pellegrino, Liang-Dar Hwang, Javier Albayay, Sachiko Koyama, Alissa Nolden, Thierry Thomas-Danguin, Carla Mucignat-Caretta, Nick S Menger, Iljia Croijmans, Lina Ozturk, Huseyin Yanik, Denis Pierron, Veronica Pereda-Loth, Alexia Nunez-Parra, Aldair M Martinez Pineda, David Gillespie, Michael C Farruggia, Cinzia Cecchetto, Marco A Fornazieri, Carl Philpott, Vera Voznessenskaya, Keiland Cooper, Paloma Rohlfs Dominguez, Orietta Calcinoni, Jasper de Groot, Sanne Boesveldt, Surabhi Bhutani, Elisabeth M Weir, Cara Exten, Paule V Joseph, Valentina Parma, John E Hayes, Masha Y Niv
August 31, 2021

ImportanceSudden smell loss is a specific early symptom of COVID-19, with an estimated prevalence of ~40% to 75%. Smell impairment affects physical and mental health, and dietary behavior. Thus, it…

Proof-of-concept: SCENTinel 1.1 rapidly discriminates COVID-19-related olfactory disorders.

Written by Stephanie R Hunter, Mackenzie E Hannum, Robert Pellegrino, Maureen A O'Leary, Nancy E Rawson, Danielle R Reed, Pamela H Dalton, Valentina Parma
January 1, 2023

It is estimated that 20%-67% of those with COVID-19 develop olfactory disorders, depending on the SARS-CoV-2 variant. However, there is an absence of quick, population-wide olfactory tests to screen for…