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Optimizing SARS-CoV-2 Wastewater Based Surveillance in Urban and University Campus Settings

Columbia University Health Sciences

Anne-Catrin Uhlemann

Wastewater
Website

Related publications

Encephalopathy and bilateral thalamic lesions in a child with MIS-C associated with COVID-19.

Written by Dori Abel, Min Ye Shen, Zaynah Abid, Claire Hennigan, Alexis Boneparth, Emily Happy Miller, Anne-Catrin Uhlemann, Danielle K McBrian, Kiran Thakur, Wendy Silver, Jennifer M Bain
October 20, 2020

Cerebrospinal Analysis in Patients With COVID-19.

Written by Emily Happy Miller, Vivian S Namale, Carla Kim, Rachelle Dugue, Greer Waldrop, Prajwal Ciryam, Alexander M Chong, Jason Zucker, Eliza C Miller, Jennifer M Bain, Joshua Z Willey, Kevin Doyle, Amelia Boehme, Jan Claassen, Anne-Catrin Uhlemann, Kiran T Thakur
October 18, 2020

BACKGROUND: Assessment of the impact of cerebrospinal fluid (CSF) analysis including investigation for the presence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is essential for the optimization of patient…

A Novel SARS-CoV-2 Variant of Concern, B.1.526, Identified in New York

Written by Medini K Annavajhala, Hiroshi Mohri, Pengfei Wang, Manoj S Nair, Jason E Zucker, Zizhang Sheng, Angela Gomez-Simmonds, Anne L Kelley, Maya Tagliavia, Yaoxing Huang, Trevor Bedford, David D Ho, Anne-Catrin Uhlemann
February 25, 2021

Recent months have seen surges of SARS-CoV-2 infection across the globe with considerable viral evolution1-3. Extensive mutations in the spike protein may threaten efficacy of vaccines and therapeutic monoclonal antibodies4.…

Supervised Machine Learning Approach to Identify Early Predictors of Poor Outcome in Patients with COVID-19 Presenting to a Large Quaternary Care Hospital in New York City.

Written by Jason Zucker, Angela Gomez-Simmonds, Lawrence J Purpura, Sherif Shoucri, Elijah LaSota, Nicholas E Morley, Brit W Sovic, Marvin A Castellon, Deborah A Theodore, Logan L Bartram, Benjamin A Miko, Matthew L Scherer, Kathrine A Meyers, William C Turner, Maureen Kelly, Martina Pavlicova, Cale N Basaraba, Matthew R Baldwin, Daniel Brodie, Kristin M Burkart, Joan Bathon, Anne-Catrin Uhlemann, Michael T Yin, Delivette Castor, Magdalena E Sobieszczyk
August 11, 2021

BACKGROUND: The progression of clinical manifestations in patients with coronavirus disease 2019 (COVID-19) highlights the need to account for symptom duration at the time of hospital presentation in decision-making algorithms.…

Trophoblast damage with acute and chronic intervillositis: disruption of the placental barrier by severe acute respiratory syndrome coronavirus 2.

Written by Larisa Debelenko, Igor Katsyv, Alexander M Chong, Leonore Peruyero, Matthias Szabolcs, Anne-Catrin Uhlemann
December 13, 2020

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was demonstrated in the placenta; however, the data on the prevalence of placental infection and associated histopathology are limited. To identify the frequency…

Neuronophagia and microglial nodules in a SARS-CoV-2 patient with cerebellar hemorrhage.

Written by Osama Al-Dalahmah, Kiran T Thakur, Anna S Nordvig, Morgan L Prust, William Roth, Angela Lignelli, Anne-Catrin Uhlemann, Emily Happy Miller, Shajo Kunnath-Velayudhan, Armando Del Portillo, Yang Liu, Gunnar Hargus, Andrew F Teich, Richard A Hickman, Kurenai Tanji, James E Goldman, Phyllis L Faust, Peter Canoll
August 26, 2020

We document the neuropathologic findings of a 73-year old man who died from acute cerebellar hemorrhage in the context of relatively mild SARS-CoV2 infection. The patient developed sudden onset of…

Hepatic pathology in patients dying of COVID-19: a series of 40 cases including clinical, histologic, and virologic data.

Written by Stephen M Lagana, Satoru Kudose, Alina C Iuga, Michael J Lee, Ladan Fazlollahi, Helen E Remotti, Armando Del Portillo, Simona De Michele, Anne Koehne de Gonzalez, Anjali Saqi, Pascale Khairallah, Alexander M Chong, Heekuk Park, Anne-Catrin Uhlemann, Jay H Lefkowitch, Elizabeth C Verna
August 13, 2020

The novel coronavirus SARS-CoV-2 (coronavirus disease 19, or COVID-19) primarily causes pulmonary injury, but has been implicated to cause hepatic injury, both by serum markers and histologic evaluation. The histologic…

Clinico-histopathologic and single-nuclei RNA-sequencing insights into cardiac injury and microthrombi in critical COVID-19.

Written by Michael I Brener, Michelle L Hulke, Nobuaki Fukuma, Stephanie Golob, Robert S Zilinyi, Zhipeng Zhou, Christos Tzimas, Ilaria Russo, Claire McGroder, Ryan D Pfeiffer, Alexander Chong, Geping Zhang, Daniel Burkhoff, Martin B Leon, Mathew S Maurer, Jeffrey W Moses, Anne-Catrin Uhlemann, Hanina Hibshoosh, Nir Uriel, Matthias J Szabolcs, Björn Redfors, Charles C Marboe, Matthew R Baldwin, Nathan R Tucker, Emily J Tsai
January 25, 2022

Acute cardiac injury is prevalent in critical COVID-19 and associated with increased mortality. Its etiology remains debated, as initially presumed causes - myocarditis and cardiac necrosis - have proved uncommon.…

Limited Utility of Procalcitonin in Identifying Community-Associated Bacterial Infections in Patients Presenting with Coronavirus Disease 2019.

Written by Michael May, Michelle Chang, Donald Dietz, Sherif Shoucri, Justin Laracy, Magdalena E Sobieszczyk, Anne-Catrin Uhlemann, Jason Zucker, Christine J Kubin
March 18, 2021

The role of procalcitonin in identifying community-associated bacterial infections among patients with coronavirus disease 2019 is not yet established. In 2,443 patients of whom 148 had bacterial coinfections, mean procalcitonin…

Partial ORF1ab Gene Target Failure with Omicron BA.2.12.1

Written by Kyle G Rodino, David R. Peaper, Brendan J Kelly, Frederic Bushman, Andrew Marques, Hriju Adhikari, Zheng Jin Tu, Rebecca Marrero Rolon, Lars F Westblade, Daniel Green, Gregory J Berry, Fann Wu, Medini K Annavajhala, Anne-Catrin Uhlemann, Bijal A Parikh, Tracy McMillen, Krupa Jani, N. Esther Babady, Anne M Hahn, Robert T Koch, Nathan D Grubaugh, - Yale SARS-CoV-2 Genomic Surveillance Initiative, Daniel D Rhoads
April 28, 2022

Mutations in the viral genome of SARS-CoV-2 can impact the performance of molecular diagnostic assays. In some cases, such as S gene target failure, the impact can serve as a…

What about tocilizumab? A retrospective study from a NYC Hospital during the COVID-19 outbreak.

Written by Monica Mehta, Lawrence J Purpura, Thomas H McConville, Matthew J Neidell, Michaela R Anderson, Elana J Bernstein, Donald E Dietz, Justin Laracy, Shauna H Gunaratne, Emily Happy Miller, Jennifer Cheng, Jason Zucker, Shivang S Shah, Shaoli Chaudhuri, Christian A Gordillo, Shreena R Patel, Tai Wei Guo, Lara E Karaaslan, Ran Reshef, Benjamin A Miko, Joan M Bathon, Marcus R Pereira, Anne-Catrin Uhlemann, Michael T Yin, Magdalena E Sobieszczyk
April 8, 2021

BACKGROUND: Tocilizumab, an interleukin-6 receptor blocker, has been used in the inflammatory phase of COVID-19, but its impact independent of corticosteroids remains unclear in patients with severe disease. METHODS: In…

Outcomes of COVID-19 in solid organ transplant recipients: A matched cohort study.

Written by Marcus R Pereira, Selim Arcasoy, Maryjane A Farr, Sumit Mohan, Jean C Emond, Demetra S Tsapepas, Qiuhu Shi, Lawrence Purpura, Anne-Catrin Uhlemann, Jason Zucker, Elizabeth C Verna
May 31, 2021

Whether solid organ transplant (SOT) recipients are at increased risk of poor outcomes due to COVID-19 in comparison to the general population remains uncertain. In this study, we compared outcomes…

Characterization of Bacterial and Fungal Infections in Hospitalized Patients With Coronavirus Disease 2019 and Factors Associated With Health Care-Associated Infections.

Written by Christine J Kubin, Thomas H McConville, Donald Dietz, Jason Zucker, Michael May, Brian Nelson, Elizabeth Istorico, Logan Bartram, Jennifer Small-Saunders, Magdalena E Sobieszczyk, Angela Gomez-Simmonds, Anne-Catrin Uhlemann
May 5, 2021

BACKGROUND: Patients hospitalized with coronavirus disease 2019 (COVID-19) are at increased risk of health care-associated infections (HAIs), especially with prolonged hospital stays. We sought to identify incidence, antimicrobial susceptibilities, and…

COVID-19 neuropathology at Columbia University Irving Medical Center/New York Presbyterian Hospital.

Written by Kiran T Thakur, Emily Happy Miller, Michael D Glendinning, Osama Al-Dalahmah, Matei A Banu, Amelia K Boehme, Alexandra L Boubour, Samuel S Bruce, Alexander M Chong, Jan Claassen, Phyllis L Faust, Gunnar Hargus, Richard A Hickman, Sachin Jambawalikar, Alexander G Khandji, Carla Y Kim, Robyn S Klein, Angela Lignelli-Dipple, Chun-Chieh Lin, Yang Liu, Michael L Miller, Gul Moonis, Anna S Nordvig, Jonathan B Overdevest, Morgan L Prust, Serge Przedborski, William H Roth, Allison Soung, Kurenai Tanji, Andrew F Teich, Dritan Agalliu, Anne-Catrin Uhlemann, James E Goldman, Peter Canoll
October 22, 2021

Many patients with SARS-CoV-2 infection develop neurological signs and symptoms; although, to date, little evidence exists that primary infection of the brain is a significant contributing factor. We present the…

Detection of SARS-CoV-2 in placental but not fetal tissues in the second trimester.

Written by Jacob E Valk, Alexander M Chong, Anne-Catrin Uhlemann, Larisa Debelenko
November 30, 2020

COVID-19 Neuropathology at Columbia University Irving Medical Center/New York Presbyterian Hospital

Written by Kiran Thakur, Emily H Miller, Michael D Glendinning, Osama Al Dalahmah, Matei Banu, Amelia K Boehme, Alex Boubour, Samuel Bruce, Alexander M Chong, Jan Claassen, Phyllis Faust, Gunnar Hargus, Richard Hickman, Sachin Jambawalikar, Alexander Khandji, Carla Kim, Robyn S Klein, Angela Lignelli-Dipple, Chun-Chieh Lin, Yang Liu, Michael Miller, Gul Moonis, Anna Nordvig, Jonathan Overdevest, Morgan Prust, Serge Przedborski, William Roth, Allison Soung, Kurenai Tanji, Andrew Teich, Dritan Agalliu, Anne-Catrin Uhlemann, James E. Goldman, Peter Canoll
March 20, 2021

Many patients with SARS-CoV-2 infection develop neurological signs and symptoms, though, to date, little evidence exists that primary infection of the brain is a significant contributing factor. We present the…

Inflammation and Mortality in COVID-19 Hospitalized Patients With and Without Type 2 Diabetes.

Written by Jia Guo, Wen-Hsuan W Lin, Jason E Zucker, Renu Nandakumar, Anne-Catrin Uhlemann, Shuang Wang, Rupak Shivakoti
April 19, 2022

CONTEXT: COVID-19 mortality is increased in patients with diabetes. A common hypothesis is that the relationship of inflammation with COVID-19 mortality differs by diabetes status. OBJECTIVE: The aim of this…

Molecular Pathophysiology of Cardiac Injury and Cardiac Microthrombi in Fatal COVID-19: Insights from Clinico-histopathologic and Single Nuclei RNA Sequencing Analyses

Written by Nobuaki Fukuma, Michelle L Hulke, Michael I Brener, Stephanie Golob, Robert Zilinyi, Zhipeng Zhou, Christos Tzimas, Ilaria Russo, Claire McGroder, Ryan Pfeiffer, Alexander Chong, Geping Zhang, Daniel Burkhoff, Martin B Leon, Mathew Maurer, Jeffrey W Moses, Anne-Catrin Uhlemann, Hanina Hibshoosh, Nil Uriel, Matthias J Szabolcs, Björn Redfors, Charles C Marboe, Matthew R Baldwin, Nathan R Tucker, Emily J Tsai
July 27, 2021

Cardiac injury is associated with critical COVID-19, yet its etiology remains debated. To elucidate the pathogenic mechanisms of COVID-19-associated cardiac injury, we conducted a single-center prospective cohort study of 69…

Reduction in risk of death among patients admitted with COVID-19 between first and second epidemic waves in New York City

Written by Anthony Bowen, Jason E. Zucker, Yanhan Shen, Simian Huang, Qiheng Yan, Medini K Annavajhala, Anne-Catrin Uhlemann, Louise Kuhn, Magdalena E Sobieszczyk, Delivette Castor
March 30, 2022

Many regions have experienced successive epidemic waves of COVID-19 since the emergence of SARS-CoV-2 with heterogeneous differences in mortality. Elucidating factors differentially associated with mortality between epidemic waves may inform…

Multiple pathways for SARS-CoV-2 resistance to nirmatrelvir

Written by Sho Iketani, Hiroshi Mohri, Bruce Culbertson, Seo Jung Hong, Yinkai Duan, Maria I. Luck, Medini K. Annavajhala, Yicheng Guo, Zizhang Sheng, Anne-Catrin Uhlemann, Stephen P. Goff, Yosef Sabo, Haitao Yang, Alejandro Chavez, David D. Ho
August 8, 2022

Nirmatrelvir, an oral antiviral targeting the 3CL protease of SARS-CoV-2, has been demonstrated to be clinically useful in reducing hospitalization or death due to COVID-191,2. However, as SARS-CoV-2 has evolved…

Multiple pathways for SARS-CoV-2 resistance to nirmatrelvir.

Written by Sho Iketani, Hiroshi Mohri, Bruce Culbertson, Seo Jung Hong, Yinkai Duan, Maria I Luck, Medini K Annavajhala, Yicheng Guo, Zizhang Sheng, Anne-Catrin Uhlemann, Stephen P Goff, Yosef Sabo, Haitao Yang, Alejandro Chavez, David D Ho
November 9, 2022

Nirmatrelvir, an oral antiviral targeting the 3CL protease of SARS-CoV-2, has been demonstrated to be clinically useful against COVID-191,2. However, as SARS-CoV-2 has evolved to become resistant to other therapeutic…

Carbapenemase-producing Enterobacterales causing secondary infections during the COVID-19 crisis at a New York City hospital.

Written by Angela Gomez-Simmonds, Medini K Annavajhala, Thomas H McConville, Donald E Dietz, Sherif M Shoucri, Justin C Laracy, Felix D Rozenberg, Brian Nelson, William G Greendyke, E Yoko Furuya, Susan Whittier, Anne-Catrin Uhlemann
January 19, 2021

BACKGROUND: Patients with COVID-19 may be at increased risk for secondary bacterial infections with MDR pathogens, including carbapenemase-producing Enterobacterales (CPE). OBJECTIVES: We sought to rapidly investigate the clinical characteristics, population…

Prolonged severe acute respiratory syndrome coronavirus 2 persistence, attenuated immunologic response, and viral evolution in a solid organ transplant patient.

Written by Lawrence J Purpura, Michelle Chang, Medini K Annavajhala, Hiroshi Mohri, Lihong Liu, Jayesh Shah, Anyelina Cantos, Nicola Medrano, Justin Laracy, Brian Scully, Benjamin A Miko, Marlena Habal, Marcus R Pereira, Moriya Tsuji, David D Ho, Anne-Catrin Uhlemann, Michael T Yin
September 20, 2021

Unlike immunocompetent hosts, the duration of viral persistence after infection with severe acute respiratory syndrome coronavirus 2 can be prolonged in immunosuppressed patients. Here, we present a case of viral…

Emergence and expansion of SARS-CoV-2 B.1.526 after identification in New York.

Written by Medini K Annavajhala, Hiroshi Mohri, Pengfei Wang, Manoj Nair, Jason E Zucker, Zizhang Sheng, Angela Gomez-Simmonds, Anne L Kelley, Maya Tagliavia, Yaoxing Huang, Trevor Bedford, David D Ho, Anne-Catrin Uhlemann
August 24, 2021

SARS-CoV-2 infections have surged across the globe in recent months, concomitant with considerable viral evolution1-3. Extensive mutations in the spike protein may threaten the efficacy of vaccines and therapeutic monoclonal…

Pretest Symptom Duration and Cycle Threshold Values for Severe Acute Respiratory Syndrome Coronavirus 2 Reverse-Transcription Polymerase Chain Reaction Predict Coronavirus Disease 2019 Mortality.

Written by Emily Happy Miller, Jason Zucker, Delivette Castor, Medini K Annavajhala, Jorge L Sepulveda, Daniel A Green, Susan Whittier, Matthew Scherer, Nicola Medrano, Magdalena E Sobieszczyk, Michael T Yin, Louise Kuhn, Anne-Catrin Uhlemann
January 4, 2021

BACKGROUND: The relationship between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral load and patient symptom duration in both in- and outpatients, and the impact of these factors on patient…

Reduction in Risk of Death Among Patients Admitted With COVID-19 Between the First and Second Epidemic Waves in New York City.

Written by Anthony Bowen, Jason Zucker, Yanhan Shen, Simian Huang, Qiheng Yan, Medini K Annavajhala, Anne-Catrin Uhlemann, Louise Kuhn, Magdalena Sobieszczyk, Delivette Castor
August 25, 2022

Background: Many regions have experienced successive epidemic waves of coronavirus disease 2019 (COVID-19) since the emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), with heterogeneous differences in mortality. Elucidating…

Oral Microbiome Alterations and SARS-CoV-2 Saliva Viral Load in Patients with COVID-19.

Written by Emily Happy Miller, Medini K Annavajhala, Alexander M Chong, Heekuk Park, Yael R Nobel, Ali Soroush, John W Blackett, Anna Krigel, Meaghan M Phipps, Daniel E Freedberg, Jason Zucker, Ellen D Sano, Anne-Catrin Uhlemann, Julian A Abrams
October 31, 2021

Bacterial-viral interactions in saliva have been associated with morbidity and mortality for respiratory viruses such as influenza and SARS-CoV. However, such transkingdom relationships during SARS-CoV-2 infection are currently unknown. Here,…

Development and performance of a point-of-care rapid antigen test for detection of SARS-COV-2 variants.

Written by Lihong Liu, Kathrine Meyers, Lawrence J Purpura, Nadia Nguyen, Hiroshi Mohri, Jennifer Y Chang, Medini K Annavajhala, Leo Lopez, Sang Won Lee, Jayesh Shah, Benjamin Lane, Anyelina Cantos, Sade A Tukuru, Yicheng Guo, Kenra Ford, Yueh-Ting Chiu, Zizhang Sheng, Tenzin Choesang, Delivette Castor, Maple Wang, Christina Pili, Michael N Van Hoy, Andrew Wallach, Jamie Horton, Zhiqiang Chen, Susan Rosenthal, Son McLaren, Baowei Jiang, Frank Wang, Helen H Lu, Anne-Catrin Uhlemann, David D Ho, Michael T Yin
May 4, 2022

Background: SARS-CoV-2 antigen-based tests are well-calibrated to infectiousness and have a critical role to play in the COVID-19 public health response. We report the development and performance of a unique…

Association between COVID-19 mRNA vaccination and COVID-19 illness and severity during Omicron BA.4 and BA.5 sublineage periods

Written by Ruth Link-Gelles, Matthew E. Levy, Karthik Natarajan, Sarah E. Reese, Allison L. Naleway, Shaun J. Grannis, Nicola P. Klein, Malini B. DeSilva, Toan C. Ong, Manjusha Gaglani, Emily Hartmann, Monica E. Dickerson, Edward Stenehjem, Anupam B. Kharbanda, Jungmi Han, Talia L. Spark, Stephanie A. Irving, Brian E. Dixon, Ousseny Zerbo, Charlene E. McEvoy, Suchitra Rao, Chandni Raiyani, Chantel Sloan-Aagard, Palak Patel, Kristin Dascomb, Anne-Catrin Uhlemann, Margaret M. Dunne, William F. Fadel, Ned Lewis, Michelle A. Barron, Kempapura Murthy, Juan Nanez, Eric P. Griggs, Nancy Grisel, Medini Annavajhala, Akintunde Akinseye, Nimish R. Valvi, Kristin Goddard, Mufaddal Mamawala, Julie Arndorfer, Duck-Hye Yang, Peter J. Embi, Bruce Fireman, Sarah W. Ball, Mark W. Tenforde
October 5, 2022

ImportanceRecent sublineages of the SARS-CoV-2 Omicron variant, including BA.4 and BA.5, may be associated with greater immune evasion and less protection against COVID-19 following vaccination.

ObjectiveTo evaluate the association between…

Partial ORF1ab Gene Target Failure with Omicron BA.2.12.1.

Written by Kyle G Rodino, David R Peaper, Brendan J Kelly, Frederic Bushman, Andrew Marques, Hriju Adhikari, Zheng Jin Tu, Rebecca Marrero Rolon, Lars F Westblade, Daniel A Green, Gregory J Berry, Fann Wu, Medini K Annavajhala, Anne-Catrin Uhlemann, Bijal A Parikh, Tracy McMillen, Krupa Jani, N Esther Babady, Anne M Hahn, Robert T Koch, Nathan D Grubaugh, Daniel D Rhoads
May 18, 2022

Mutations in the genome of SARS-CoV-2 can affect the performance of molecular diagnostic assays. In some cases, such as S-gene target failure, the impact can serve as a unique indicator…

Estimation of COVID-19 mRNA Vaccine Effectiveness and COVID-19 Illness and Severity by Vaccination Status During Omicron BA.4 and BA.5 Sublineage Periods.

Written by Ruth Link-Gelles, Matthew E Levy, Karthik Natarajan, Sarah E Reese, Allison L Naleway, Shaun J Grannis, Nicola P Klein, Malini B DeSilva, Toan C Ong, Manjusha Gaglani, Emily Hartmann, Monica Dickerson, Edward Stenehjem, Anupam B Kharbanda, Jungmi Han, Talia L Spark, Stephanie A Irving, Brian E Dixon, Ousseny Zerbo, Charlene E McEvoy, Suchitra Rao, Chandni Raiyani, Chantel Sloan-Aagard, Palak Patel, Kristin Dascomb, Anne-Catrin Uhlemann, Margaret M Dunne, William F Fadel, Ned Lewis, Michelle A Barron, Kempapura Murthy, Juan Nanez, Eric P Griggs, Nancy Grisel, Medini K Annavajhala, Akintunde Akinseye, Nimish R Valvi, Kristin Goddard, Mufaddal Mamawala, Julie Arndorfer, Duck-Hye Yang, Peter J Embí, Bruce Fireman, Sarah W Ball, Mark W Tenforde
March 1, 2023

IMPORTANCE: Recent SARS-CoV-2 Omicron variant sublineages, including BA.4 and BA.5, may be associated with greater immune evasion and less protection against COVID-19 after vaccination. OBJECTIVES: To evaluate the estimated vaccine…

A replication-competent vesicular stomatitis virus for studies of SARS-CoV-2 spike-mediated cell entry and its inhibition

Written by M Eugenia Dieterle, Denise Haslwanter, Robert H Bortz III, Ariel S Wirchnianski, Gorka Lasso, Olivia Vergnolle, Shawn A Abbasi, J Maximilian Fels, Ethan Laudermilch, Catalina Florez, Amanda Mengotto, Duncan Kimmel, Ryan J Malonis, George Georgiev, Jose Quiroz, Jason Barnhill, Liise-Anne Pirofski, Johanna P Daily, John M Dye, Jonathan R Lai, Andrew S Herbert, Kartik Chandran, Rohit K Jangra
May 20, 2020

There is an urgent need for vaccines and therapeutics to prevent and treat COVID-19. Rapid SARS-CoV-2 countermeasure development is contingent on the availability of robust, scalable, and readily deployable surrogate…

Genomic surveillance of SARS-CoV-2 in the Bronx enables clinical and epidemiological inference

Written by J. Maximilian Fels, Saad Khan, Ryan Forster, Karin A Skalina, Surksha Sirichand, Amy S Fox, Aviv Bergman, William B Mitchell, Lucia R Wolgast, Wendy A Szymczak, Robert H Bortz III, M Eugenia Dieterle, Catalina Florez, Denise Haslwanter, Rohit K Jangra, Ethan Laudermilch, Ariel S Wirchnianski, Jason Barnhill, David L Goldman, Hnin Khine, D. Yitzchak Goldstein, Johanna P Daily, Kartik Chandran, Libusha Kelly
February 10, 2021

The Bronx was an early epicenter of the COVID-19 pandemic in the USA. We conducted temporal genomic surveillance of SARS-CoV-2 genomes across the Bronx from March-October 2020. Although the local…

Characterization of the SARS-CoV-2 S Protein: Biophysical, Biochemical, Structural, and Antigenic Analysis

Written by Natalia G Herrera, Nicholas C Morano, Alev Celikgil, George I Georgiev, Ryan J Malonis, James H Lee, Karen Tong, Olivia Vergnolle, Aldo B Massimi, Laura Y Yen, Alex J Noble, Mykhailo Kopylov, Jeffrey B Bonanno, Sarah C Garrett-Thomson, David B Hayes, Robert H Bortz, Ariel S Wirchniaski, Catalina Florez, Ethan Laudermilch, Denise Haslwanter, J Maximilian Fels, M Eugenia Dieterle, Rohit K Jangra, Jason Barnhill, Amanda Mengotto, Duncan Kimmel, Johanna P Daily, Liise-anne Pirofski, Kartik Chandran, Michael Brenowitz, Scott J Garforth, Edward T Eng, Jonathan R Lai, Steven C Almo
June 15, 2020

Coronavirus disease 2019 (COVID-19) is a global health crisis caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and there is a critical need to produce large quantities…

Broad sarbecovirus neutralizing antibodies define a key site of vulnerability on the SARS-CoV-2 spike protein

Written by Anna Z Wec, Daniel Wrapp, Andrew S Herbert, Daniel P Maurer, Denise Haslwanter, Mrunal Sakharkar, Rohit K Jangra, M. Eugenia Dieterle, Asparouh Lilov, Deli Huang, Longping V Tse, Nicole V Johnson, Ching-Lin Hsieh, Nianshuang Wang, Juergen H Nett, Elizabeth Champney, Irina Burnina, Michael Brown, Shu Lin, Melanie Sinclair, Carl Johnson, Sarat Pudi, Robert Bortz III, Ariel S Wirchnianski, Ethan Laudermilch, Catalina Florez, J. Maximilian Fels, Barney S Graham, David Nemazee, Dennis R Burton, Ralph S Baric, James E Voss, Kartik Chandran, John M Dye, Jason S McLellan, Laura M Walker
May 15, 2020

Broadly protective vaccines against known and pre-emergent coronaviruses are urgently needed. Critical to their development is a deeper understanding of cross-neutralizing antibody responses induced by natural human coronavirus (HCoV) infections.…

Genomic surveillance of SARS-CoV-2 during the first year of the pandemic in the Bronx enabled clinical and epidemiological inference.

Written by J Maximilian Fels, Saad Khan, Ryan Forster, Karin A Skalina, Surksha Sirichand, Amy S Fox, Aviv Bergman, William B Mitchell, Lucia R Wolgast, Wendy A Szymczak, Robert H Bortz, M Eugenia Dieterle, Catalina Florez, Denise Haslwanter, Rohit K Jangra, Ethan Laudermilch, Ariel S Wirchnianski, Jason Barnhill, David L Goldman, Hnin Khine, D Yitzchak Goldstein, Johanna P Daily, Kartik Chandran, Libusha Kelly
July 13, 2022

The Bronx was an early epicenter of the COVID-19 pandemic in the USA. We conducted temporal genomic surveillance of 104 SARS-CoV-2 genomes across the Bronx from March October 2020. Although…

Treatment of severe COVID-19 with convalescent plasma in Bronx, NYC.

Written by Hyun Ah Yoon, Rachel Bartash, Inessa Gendlina, Johanna Rivera, Antonio Nakouzi, Robert H Bortz, Ariel S Wirchnianski, Monika Paroder, Karen Fehn, Leana Serrano-Rahman, Rachelle Babb, Uzma N Sarwar, Denise Haslwanter, Ethan Laudermilch, Catalina Florez, M Eugenia Dieterle, Rohit K Jangra, J Maximilian Fels, Karen Tong, Margarette C Mariano, Olivia Vergnolle, George I Georgiev, Natalia G Herrera, Ryan J Malonis, Jose A Quiroz, Nicholas C Morano, Gregory J Krause, Joseph M Sweeney, Kelsie Cowman, Stephanie Allen, Jayabhargav Annam, Ariella Applebaum, Daniel Barboto, Ahmed Khokhar, Brianna J Lally, Audrey Lee, Max Lee, Avinash Malaviya, Reise Sample, Xiuyi A Yang, Yang Li, Rafael Ruiz, Raja Thota, Jason Barnhill, Doctor Y Goldstein, Joan Uehlinger, Scott J Garforth, Steven C Almo, Jonathan R Lai, Morayma Reyes Gil, Amy S Fox, Kartik Chandran, Tao Wang, Johanna P Daily, Liise-Anne Pirofski
February 22, 2021

Convalescent plasma with severe acute respiratory disease coronavirus 2 (SARS-CoV-2) antibodies (CCP) may hold promise as a treatment for coronavirus disease 2019 (COVID-19). We compared the mortality and clinical outcome…

A Combination of Receptor-Binding Domain and N-Terminal Domain Neutralizing Antibodies Limits the Generation of SARS-CoV-2 Spike Neutralization-Escape Mutants.

Written by Denise Haslwanter, M Eugenia Dieterle, Anna Z Wec, Cecilia M O'Brien, Mrunal Sakharkar, Catalina Florez, Karen Tong, C Garrett Rappazzo, Gorka Lasso, Olivia Vergnolle, Ariel S Wirchnianski, Robert H Bortz, Ethan Laudermilch, J Maximilian Fels, Amanda Mengotto, Ryan J Malonis, George I Georgiev, Jose A Quiroz, Daniel Wrapp, Nianshuang Wang, Kathryn E Dye, Jason Barnhill, John M Dye, Jason S McLellan, Johanna P Daily, Jonathan R Lai, Andrew S Herbert, Laura M Walker, Kartik Chandran, Rohit K Jangra
October 26, 2021

Most known SARS-CoV-2 neutralizing antibodies (nAbs), including those approved by the FDA for emergency use, inhibit viral infection by targeting the receptor-binding domain (RBD) of the spike (S) protein. Variants…

Broad neutralization of SARS-related viruses by human monoclonal antibodies.

Written by Anna Z Wec, Daniel Wrapp, Andrew S Herbert, Daniel P Maurer, Denise Haslwanter, Mrunal Sakharkar, Rohit K Jangra, M Eugenia Dieterle, Asparouh Lilov, Deli Huang, Longping V Tse, Nicole V Johnson, Ching-Lin Hsieh, Nianshuang Wang, Juergen H Nett, Elizabeth Champney, Irina Burnina, Michael Brown, Shu Lin, Melanie Sinclair, Carl Johnson, Sarat Pudi, Robert Bortz, Ariel S Wirchnianski, Ethan Laudermilch, Catalina Florez, J Maximilian Fels, Cecilia M O'Brien, Barney S Graham, David Nemazee, Dennis R Burton, Ralph S Baric, James E Voss, Kartik Chandran, John M Dye, Jason S McLellan, Laura M Walker
August 7, 2020

Broadly protective vaccines against known and preemergent human coronaviruses (HCoVs) are urgently needed. To gain a deeper understanding of cross-neutralizing antibody responses, we mined the memory B cell repertoire of…

Development, clinical translation, and utility of a COVID-19 antibody test with qualitative and quantitative readouts

Written by Robert H. Bortz III, Catalina Florez, Ethan Laudermilch, Ariel S Wirchnianski, Gorka Lasso, Ryan J Malonis, George I Georgiev, Olivia Vergnolle, Natalia G Herrera, Nicholas C Morano, Sean T Campbell, Erika P. Orner, Amanda Mengotto, M Eugenia Dieterle, Jens Maximilian Fels, Denise Haslwanter, Rohit Jangra, Alev Celikgil, Duncan Kimmel, James H Lee, Margarette Mariano, Antonio Nakouzi, Jose Quiroz, Johanna Rivera, Wendy A Szymczak, Karen Tong, Jason Barnhill, Mattias NE Forsell, Clas Ahlm, Daniel T. Stein, Liise-anne Pirofski, Doctor Y Goldstein, Scott J. Garforth, Steven C. Almo, Johanna P. Daily, Michael B. Prystowsky, James D. Faix, Amy S. Fox, Louis M. Weiss, Jonathan R. Lai, Kartik Chandran
September 11, 2020

The COVID-19 global pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) continues to place an immense burden on societies and healthcare systems. A key component of COVID-19 control efforts…

Efficacy and Safety of COVID-19 Convalescent Plasma in Hospitalized Patients: A Randomized Clinical Trial.

Written by Mila B Ortigoza, Hyunah Yoon, Keith S Goldfeld, Andrea B Troxel, Johanna P Daily, Yinxiang Wu, Yi Li, Danni Wu, Gia F Cobb, Gillian Baptiste, Mary O'Keeffe, Marilou O Corpuz, Luis Ostrosky-Zeichner, Amee Amin, Ioannis M Zacharioudakis, Dushyantha T Jayaweera, Yanyun Wu, Julie V Philley, Megan S Devine, Mahalia S Desruisseaux, Alessandro D Santin, Shweta Anjan, Reeba Mathew, Bela Patel, Masayuki Nigo, Rabi Upadhyay, Tania Kupferman, Andrew N Dentino, Rahul Nanchal, Christian A Merlo, David N Hager, Kartik Chandran, Jonathan R Lai, Johanna Rivera, Chowdhury R Bikash, Gorka Lasso, Timothy P Hilbert, Monika Paroder, Andrea A Asencio, Mengling Liu, Eva Petkova, Alexander Bragat, Reza Shaker, David D McPherson, Ralph L Sacco, Marla J Keller, Corita R Grudzen, Judith S Hochman, Liise-Anne Pirofski, Lalitha Parameswaran, Anthony T Corcoran, Abhinav Rohatgi, Marta W Wronska, Xinyuan Wu, Ranjini Srinivasan, Fang-Ming Deng, Thomas D Filardo, Jay Pendse, Simone B Blaser, Olga Whyte, Jacqueline M Gallagher, Ololade E Thomas, Danibel Ramos, Caroline L Sturm-Reganato, Charlotte C Fong, Ivy M Daus, Arianne Gisselle Payoen, Joseph T Chiofolo, Mark T Friedman, Ding Wen Wu, Jessica L Jacobson, Jeffrey G Schneider, Uzma N Sarwar, Henry E Wang, Ryan M Huebinger, Goutham Dronavalli, Yu Bai, Carolyn Z Grimes, Karen W Eldin, Virginia E Umana, Jessica G Martin, Timothy R Heath, Fatimah O Bello, Daru Lane Ransford, Maudry Laurent-Rolle, Sheela V Shenoi, Oscar Bate Akide-Ndunge, Bipin Thapa, Jennifer L Peterson, Kelly Knauf, Shivani U Patel, Laura L Cheney, Christopher A Tormey, Jeanne E Hendrickson
February 1, 2022

Importance: There is clinical equipoise for COVID-19 convalescent plasma (CCP) use in patients hospitalized with COVID-19. Objective: To determine the safety and efficacy of CCP compared with placebo in hospitalized…

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Qualitative Immunoglobulin G Assays: The Value of Numeric Reporting.

Written by Stefanie K Forest, Erika P Orner, D Yitzchak Goldstein, Ariel S Wirchnianski, Robert H Bortz, Ethan Laudermilch, Catalina Florez, Ryan J Malonis, George I Georgiev, Olivia Vergnolle, Yungtai Lo, Sean T Campbell, Jason Barnhill, Evan M Cadoff, Jonathan R Lai, Kartik Chandran, Louis M Weiss, Amy S Fox, Michael B Prystowsky, Lucia R Wolgast
August 1, 2021

CONTEXT.—: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) immunoglobulin G (IgG) testing is used for serosurveillance and will be important to evaluate vaccination status. Given the urgency to release coronavirus…

Characterization of the SARS-CoV-2 S Protein: Biophysical, Biochemical, Structural, and Antigenic Analysis.

Written by Natalia G Herrera, Nicholas C Morano, Alev Celikgil, George I Georgiev, Ryan J Malonis, James H Lee, Karen Tong, Olivia Vergnolle, Aldo B Massimi, Laura Y Yen, Alex J Noble, Mykhailo Kopylov, Jeffrey B Bonanno, Sarah C Garrett-Thomson, David B Hayes, Robert H Bortz, Ariel S Wirchnianski, Catalina Florez, Ethan Laudermilch, Denise Haslwanter, J Maximilian Fels, M Eugenia Dieterle, Rohit K Jangra, Jason Barnhill, Amanda Mengotto, Duncan Kimmel, Johanna P Daily, Liise-Anne Pirofski, Kartik Chandran, Michael Brenowitz, Scott J Garforth, Edward T Eng, Jonathan R Lai, Steven C Almo
January 12, 2021

Coronavirus disease 2019 (COVID-19) is a global health crisis caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and there is a critical need to produce large quantities…

Treatment of Severe COVID-19 with Convalescent Plasma in the Bronx, NYC

Written by Hyun ah Yoon, Rachel Bartash, Inessa Gendlina, Johanna Rivera, Antonio Nakouzi, Robert H. Bortz III, Ariel S. Wirchnianski, Monika Paroder, Karen Fehn, Leana Serrano-Rahman, Rachelle Babb, Uzma N. Sarwar, Denise Haslwanter, Ethan Laudermilch, Catalina Florez, M. Eugenia Dieterle, Rohit K. Jangra, J. Maximilian Fels, Karen Tong, Margarette C. Mariano, Olivia Vergnolle, George I. Georgiev, Natalia G. Herrera, Ryan J. Malonis, Jose A. Quiroz, Nicholas C. Morano, Gregory J. Krause, Joseph M. Sweeney, Kelsie Cowman, Stephanie Allen, Jayabhargav Annam, Ariella Applebaum, Daniel Barboto, Ahmed Khokhar, Brianna J. Lally, Audrey Lee, Max Lee, Avinash Malaviya, Reise Sample, Xiuyi A. Yang, Yang Li, Rafael Ruiz, Raja Thota, Jason Barnhill, Doctor Y. Goldstein, Joan Uehlinger, Scott J. Garforth, Steven C. Almo, Jonathan R. Lai, Morayma Reyes Gil, Amy S. Fox, Kartik Chandran, Tao Wang, Johanna P. Daily, Liise-anne Pirofski
December 4, 2020

Convalescent plasma with severe acute respiratory disease coronavirus 2 (SARS-CoV-2) antibodies (CCP) may hold promise as treatment for Coronavirus Disease 2019 (COVID-19). We compared the mortality and clinical outcome of…

Single-Dilution COVID-19 Antibody Test with Qualitative and Quantitative Readouts.

Written by Robert H Bortz, Catalina Florez, Ethan Laudermilch, Ariel S Wirchnianski, Gorka Lasso, Ryan J Malonis, George I Georgiev, Olivia Vergnolle, Natalia G Herrera, Nicholas C Morano, Sean T Campbell, Erika P Orner, Amanda Mengotto, M Eugenia Dieterle, J Maximilian Fels, Denise Haslwanter, Rohit K Jangra, Alev Celikgil, Duncan Kimmel, James H Lee, Margarette C Mariano, Antonio Nakouzi, Jose Quiroz, Johanna Rivera, Wendy A Szymczak, Karen Tong, Jason Barnhill, Mattias N E Forsell, Clas Ahlm, Daniel T Stein, Liise-Anne Pirofski, D Yitzchak Goldstein, Scott J Garforth, Steven C Almo, Johanna P Daily, Michael B Prystowsky, James D Faix, Amy S Fox, Louis M Weiss, Jonathan R Lai, Kartik Chandran
April 21, 2021

The coronavirus disease 2019 (COVID-19) global pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to place an immense burden on societies and health care systems. A key…

Long-lasting neutralizing antibody responses in SARS-CoV-2 seropositive individuals are robustly boosted by immunization with the CoronaVac and BNT162b2 vaccines

Written by Nicolas A. Muena, Tamara Garcia-Salum, Catalina Pardo-Roa, Eileen F. Serrano, Jorge Levican, Maria Jose Avendano, Leonardo I. Almonacid, Gonzalo Valenzuela, Estefany Poblete, Shirin Strohmeier, Erick Salinas, Denise Haslwanter, Maria Eugenia Dieterle, Rohit K. Jangra, Kartik Chandran, Claudia Gonzalez, Arnoldo Riquelme, Florian Krammer, Nicole D. Tischler, Rafael A. Medina
May 18, 2021

The durability of circulating neutralizing antibody (nAb) responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and their boosting by vaccination remains to be defined. We show that outpatient…

Immune responses to SARS-CoV-2 infection in hospitalized pediatric and adult patients.

Written by Carl A Pierce, Paula Preston-Hurlburt, Yile Dai, Clare Burn Aschner, Natalia Cheshenko, Benjamin Galen, Scott J Garforth, Natalia G Herrera, Rohit K Jangra, Nicholas C Morano, Erika Orner, Sharlene Sy, Kartik Chandran, James Dziura, Steven C Almo, Aaron Ring, Marla J Keller, Kevan C Herold, Betsy C Herold
October 7, 2020

Children and youth infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have milder disease than do adults, and even among those with the recently described multisystem inflammatory syndrome, mortality…

S-Palmitoylation and Sterol Interactions Mediate Antiviral Specificity of IFITMs.

Written by Tandrila Das, Xinglin Yang, Hwayoung Lee, Emma H Garst, Estefania Valencia, Kartik Chandran, Wonpil Im, Howard C Hang
July 21, 2022

Interferon-induced transmembrane proteins (IFITM1, 2, and 3) are important antiviral proteins that are active against many viruses, including influenza A virus (IAV), dengue virus (DENV), Ebola virus (EBOV), Zika virus…

Induction of SARS-CoV-2 neutralizing antibodies by CoronaVac and BNT162b2 vaccines in naïve and previously infected individuals.

Written by Nicolás A Muena, Tamara García-Salum, Catalina Pardo-Roa, María José Avendaño, Eileen F Serrano, Jorge Levican, Leonardo I Almonacid, Gonzalo Valenzuela, Estefany Poblete, Shirin Strohmeier, Erick Salinas, Andres Muñoz, Denise Haslwanter, Maria Eugenia Dieterle, Rohit K Jangra, Kartik Chandran, Claudia González, Arnoldo Riquelme, Florian Krammer, Nicole D Tischler, Rafael A Medina
March 30, 2022

BACKGROUND: A major challenge of the SARS-CoV-2 pandemic is to better define "protective thresholds" to guide the global response. We aimed to characterize the longitudinal dynamics of the antibody responses…

A Replication-Competent Vesicular Stomatitis Virus for Studies of SARS-CoV-2 Spike-Mediated Cell Entry and Its Inhibition.

Written by M Eugenia Dieterle, Denise Haslwanter, Robert H Bortz, Ariel S Wirchnianski, Gorka Lasso, Olivia Vergnolle, Shawn A Abbasi, J Maximilian Fels, Ethan Laudermilch, Catalina Florez, Amanda Mengotto, Duncan Kimmel, Ryan J Malonis, George Georgiev, Jose Quiroz, Jason Barnhill, Liise-Anne Pirofski, Johanna P Daily, John M Dye, Jonathan R Lai, Andrew S Herbert, Kartik Chandran, Rohit K Jangra
September 9, 2020

There is an urgent need for vaccines and therapeutics to prevent and treat COVID-19. Rapid SARS-CoV-2 countermeasure development is contingent on the availability of robust, scalable, and readily deployable surrogate…

The evolutionary history of ACE2 usage within the coronavirus subgenus Sarbecovirus

Written by Heather L Wells, Michael C Letko, Gorka Lasso, Benard Ssebide, Julius Nziza, Denis K Byarugaba, Isamara Navarrete-Macias, Eliza Liang, Michael Cranfield, Barbara A Han, Morgan W Tingley, Maria Diuk-Wasser, Tracey Goldstein, Christine Kreuder Johnson, Jonna Mazet, Kartik Chandran, Vincent Munster, Kirsten Gilardi, Simon J Anthony
July 7, 2020

SARS-CoV-1 and SARS-CoV-2 are not phylogenetically closely related; however, both use the ACE2 receptor in humans for cell entry. This is not a universal sarbecovirus trait; for example, many known…

Analysis of SARS-CoV-2 amino acid mutations in New York City Metropolitan wastewater (2020-2022) reveals multiple traits with human health implications across the genome and environment-specific distinctions

Written by Archana Anand, Chenghua Long, Kartik Chandran
July 17, 2022

We characterize variant diversity, amino acid mutation frequency, functionality and associations with COVID-19 infections in one of the largest datasets of SARS-CoV-2 genome sequences collected from wastewater in the New…

Longitudinally monitored immune biomarkers predict the timing of COVID-19 outcomes.

Written by Gorka Lasso, Saad Khan, Stephanie A Allen, Margarette Mariano, Catalina Florez, Erika P Orner, Jose A Quiroz, Gregory Quevedo, Aldo Massimi, Aditi Hegde, Ariel S Wirchnianski, Robert H Bortz, Ryan J Malonis, George I Georgiev, Karen Tong, Natalia G Herrera, Nicholas C Morano, Scott J Garforth, Avinash Malaviya, Ahmed Khokhar, Ethan Laudermilch, M Eugenia Dieterle, J Maximilian Fels, Denise Haslwanter, Rohit K Jangra, Jason Barnhill, Steven C Almo, Kartik Chandran, Jonathan R Lai, Libusha Kelly, Johanna P Daily, Olivia Vergnolle
January 18, 2022

The clinical outcome of SARS-CoV-2 infection varies widely between individuals. Machine learning models can support decision making in healthcare by assessing fatality risk in patients that do not yet show…

Functional Antibodies in COVID-19 Convalescent Plasma

Written by Jonathan D Herman, Chuangqi Wang, Carolin Loos, Hyun ah Yoon, Johanna Rivera, M. Eugenia Dieterle, Denise Haslwanter, Rohit K Jangra, Robert Bortz, Katharine Bar, Boris Julg, Kartik Chandran, Liise-anne Pirofski, Douglas Lauffenburger, Galit Alter
March 11, 2021

In the absence of an effective vaccine or monoclonal therapeutic, transfer of convalescent plasma (CCP) was proposed early in the SARS-CoV-2 pandemic as an easily accessible therapy. However, despite the…

Approaching the Interpretation of Discordances in SARS-CoV-2 Testing.

Written by Sandeep N Wontakal, Robert H Bortz, Wen-Hsuan W Lin, Inessa Gendlina, Amy S Fox, Eldad A Hod, Kartik Chandran, Michael B Prystowsky, Louis M Weiss, Steven L Spitalnik
March 23, 2021

The coronavirus disease 2019 pandemic has upended life throughout the globe. Appropriate emphasis has been placed on developing effective therapies and vaccines to curb the pandemic. While awaiting such countermeasures,…

Cell-impermeable staurosporine analog targets extracellular kinases to inhibit HSV and SARS-CoV-2.

Written by Natalia Cheshenko, Jeffrey B Bonanno, Hans-Heinrich Hoffmann, Rohit K Jangra, Kartik Chandran, Charles M Rice, Steven C Almo, Betsy C Herold
October 16, 2022

Herpes simplex virus (HSV) receptor engagement activates phospholipid scramblase triggering Akt translocation to the outer leaflet of the plasma membrane where its subsequent phosphorylation promotes viral entry. We hypothesize that…

A combination of RBD and NTD neutralizing antibodies limits the generation of SARS-CoV-2 spike neutralization-escape mutants

Written by Denise Haslwanter, M. Eugenia Dieterle, Anna Z. Wec, Mrunal Sakharkar, Catalina Florez, Karen Tong, C. Garrett Rappazzo, Gorka Lasso, Olivia Vergnolle, Ariel S. Wirchnianski, Robert H. Bortz III, Ethan Laudermilch, J. Maximilian Fels, Amanda Mengotto, Ryan J Malonis, George I Georgiev, Jose Quiroz, Daniel Wrapp, Nianshuang Wang, Jason Barnhill, John M Dye, Jason S. McLellan, Johanna P. Daily, Jonathan R. Lai, Andrew S Herbert, Laura Walker, Kartik Chandran, Rohit K. Jangra
June 11, 2021

Most known SARS-CoV-2 neutralizing antibodies (nAbs), including those approved by the FDA for emergency use, inhibit viral infection by targeting the receptor-binding domain (RBD) of the spike (S) protein. Variants…

Functional convalescent plasma antibodies and pre-infusion titers shape the early severe COVID-19 immune response.

Written by Jonathan D Herman, Chuangqi Wang, Carolin Loos, Hyunah Yoon, Johanna Rivera, M Eugenia Dieterle, Denise Haslwanter, Rohit K Jangra, Robert H Bortz, Katharine J Bar, Boris Julg, Kartik Chandran, Douglas Lauffenburger, Liise-Anne Pirofski, Galit Alter
November 25, 2021

Transfer of convalescent plasma (CP) had been proposed early during the SARS-CoV-2 pandemic as an accessible therapy, yet trial results worldwide have been mixed, potentially due to the heterogeneous nature…