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Identifying Biomarker Signatures of Prognostic Value for Multisystem Inflammatory Syndrome in Children (MIS-C)

Connecticut Children's Medical Center

Juan Salazar

PreVAIL kIds
Website

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Written by Alexandre Bolze, Iva Neveux, Kelly M Schiabor Barrett, Simon White, Magnus Isaksson, Shaun Dabe, William Lee, Joseph J Grzymski, Nicole L Washington, Elizabeth T Cirulli
April 14, 2022

COVID-19 vaccines are safe and highly effective, but some individuals experience unpleasant reactions to vaccination. As the majority of adults in the United States have received a COVID-19 vaccine this…

COVID-19 Serology Control Panel Using the Dried-Tube Specimen Method.

Written by William J Windsor, Vijaya Knight, Patricia A Merkel, Molly M Lamb, Heidi R Tucker, Kyle Carson, Kelly M Howard, Jennifer L Yates, Mario L Santiago, Mary K McCarthy, Thomas E Morrison, Ross M Kedl, Ashley Frazer-Abel, Kejun Guo, Gillian Andersen, Leah Huey, Bradley S Barrett, Jessica M Colón-Franco, William T Lee, May C Chu
January 7, 2022

The dried-tube specimen (DTS) procedure was used to develop the COVID-19 serology control panel (CSCP). The DTS offers the benefit of shipping materials without a cold chain, allowing for greater…

In Utero Vertical Transmission of Coronavirus Disease 2019 in a Severely Ill 29-week Preterm Infant.

Written by Arpit Gupta, Yogangi Malhotra, Uday Patil, Ana R Muradas, William T Lee, Florian Krammer, Fatima Amanat, Camille A Clare, Suja Vinod, Emad Ghaly
September 16, 2020

Severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) or coronavirus disease 2019 (COVID-19) is currently in worldwide pandemic state with very limited data about the mode of transmission to the growing…

Multiplexed detection and quantification of human antibody response to COVID-19 infection using a plasmon enhanced biosensor platform.

Written by Nathaniel C Cady, Natalya Tokranova, Armond Minor, Nima Nikvand, Klemen Strle, William T Lee, William Page, Ernest Guignon, Arturo Pilar, George N Gibson
January 1, 2021

The 2019 SARS CoV-2 (COVID-19) pandemic has illustrated the need for rapid and accurate diagnostic tests. In this work, a multiplexed grating-coupled fluorescent plasmonics (GC-FP) biosensor platform was used to…

Evidence for SARS-CoV-2 Delta and Omicron co-infections and recombination

Written by Alexandre Bolze, Tracy Basler, Simon White, Andrew Dei Rossi, Dana Wyman, Pavitra Roychoudhury, Alexander L. Greninger, Kathleen Hayashibara, Eric Kil, Hang Dai, Tyler Cassens, Kevin Tsan, Jason Nguyen, Jimmy Ramirez, Scotty Carter, Elizabeth T. Cirulli, Kelly Schiabor Barrett, Nicole L Washington, Pedro Belda-Ferre, Sharoni Jacobs, Efren Sandoval, David Becker, James T Lu, Magnus Isaksson, William Lee, Shishi Luo
March 12, 2022

Between November 2021 and February 2022, SARS-CoV-2 Delta and Omicron variants co-circulated in the United States, allowing for co-infections and possible recombination events. We sequenced 29,719 positive samples during this…

Serological analysis reveals an imbalanced IgG subclass composition associated with COVID-19 disease severity.

Written by Jennifer L Yates, Dylan J Ehrbar, Danielle T Hunt, Roxanne C Girardin, Alan P Dupuis, Anne F Payne, Mycroft Sowizral, Scott Varney, Karen E Kulas, Valerie L Demarest, Kelly M Howard, Kyle Carson, Margaux Hales, Monir Ejemel, Qi Li, Yang Wang, Ruben Peredo-Wende, Ananthakrishnan Ramani, Gurpreet Singh, Klemen Strle, Nicholas J Mantis, Kathleen A McDonough, William T Lee
July 20, 2021

Coronavirus disease 2019 (COVID-19) is associated with a wide spectrum of disease presentation, ranging from asymptomatic infection to acute respiratory distress syndrome (ARDS). Paradoxically, a direct relationship has been suggested…

Identification of Omicron-Delta Coinfections Using PCR-Based Genotyping.

Written by Pavitra Roychoudhury, Shishi Luo, Kathleen Hayashibara, Pooneh Hajian, Margaret G Mills, Jean Lozach, Tyler Cassens, Seffir T Wendm, Isabel Arnould, David Becker, Tim Wesselman, Jeremy Davis-Turak, Richard Creager, Eric Lai, Keith R Jerome, Tracy Basler, Andrew Dei Rossi, William Lee, Alexander L Greninger
May 3, 2022

Impact of COVID-19 on mental health research: is this the breaking point?

Written by Oli Sparasci, Kamaldeep Bhui, Asit Biswas, Samuel Chamberlain, Bernadka Dubicka, Robert Dudas, Saeed Farooq, Tamsin Ford, Nusrat Husain, Ian Jones, Helen Killaspy, William Lee, Anne Lingford-Hughes, Ciaran Mulholland, Judy Rubinsztein, Rohit Shankar, Aditya Sharma, Lindsey Sinclair, James Stone, Allan Young
February 17, 2022

There are many structural problems facing the UK at present, from a weakened National Health Service to deeply ingrained inequality. These challenges extend through society to clinical practice and have…

SARS-CoV-2 antibody characterization in emergency department, hospitalized and convalescent patients by two semi-quantitative immunoassays.

Written by He S Yang, Sabrina E Racine-Brzostek, William T Lee, Danielle Hunt, Jim Yee, Zhengming Chen, Jeffrey Kubiak, Miguel Cantu, Layla Hatem, Elaine Zhong, Danielle D'Ambrosio, Amy Chadburn, Lars Westblade, Marshall Glesby, Massimo Loda, Melissa M Cushing, Zhen Zhao
June 4, 2020

BACKGROUND: In the ongoing COVID-19 pandemic, there is an urgent need for comprehensive performance evaluation and clinical utility assessment of serological assays to understand the immune response to SARS-CoV-2. METHODS:…

SARS-CoV-2 antibody characterization in emergency department, hospitalized and convalescent patients by two semi-quantitative immunoassays.

Written by He S Yang, Sabrina E Racine-Brzostek, William T Lee, Danielle Hunt, Jim Yee, Zhengming Chen, Jeffrey Kubiak, Miguel Cantu, Layla Hatem, Elaine Zhong, Danielle D'Ambrosio, Amy Chadburn, Lars Westblade, Marshall Glesby, Massimo Loda, Melissa M Cushing, Zhen Zhao
June 4, 2020

BACKGROUND: In the ongoing COVID-19 pandemic, there is an urgent need for comprehensive performance evaluation and clinical utility assessment of serological assays to understand the immune response to SARS-CoV-2. METHODS:…

Rapid displacement of SARS-CoV-2 variant B.1.1.7 by B.1.617.2 and P.1 in the United States

Written by Alexandre Bolze, Elizabeth T Cirulli, Shishi Luo, Simon White, Dana Wyman, Andrew Dei Rossi, Henrique Machado, Tyler Cassens, Sharoni Jacobs, Kelly M. Schiabor Barrett, Kevin Tsan, Jason Nguyen, Jimmy M. Ramirez III, Efren Sandoval, Xueqing Wang, David Wong, David Becker, Marc Laurent, James Lu, Magnus Isaksson, Nicole L Washington, William Lee
June 21, 2021

This study reports on the displacement of Alpha (B.1.1.7) by Delta (B.1.617.2 and its substrains AY.1, AY.2, and AY.3) in the United States. By analyzing RT-qPCR testing results and viral…

SARS-CoV-2 variant Delta rapidly displaced variant Alpha in the United States and led to higher viral loads.

Written by Alexandre Bolze, Shishi Luo, Simon White, Elizabeth T Cirulli, Dana Wyman, Andrew Dei Rossi, Henrique Machado, Tyler Cassens, Sharoni Jacobs, Kelly M Schiabor Barrett, Francisco Tanudjaja, Kevin Tsan, Jason Nguyen, Jimmy M Ramirez, Efren Sandoval, Xueqing Wang, David Wong, David Becker, Marc Laurent, James T Lu, Magnus Isaksson, Nicole L Washington, William Lee
March 15, 2022

We report on the sequencing of 74,348 SARS-CoV-2 positive samples collected across the United States and show that the Delta variant, first detected in the United States in March 2021,…

Development of a biomarker signature using grating-coupled fluorescence plasmonic microarray for diagnosis of MIS-C.

Written by Michele Maltz-Matyschsyk, Clare K Melchiorre, Katherine W Herbst, Alexander H Hogan, Kristina Dibble, Brandon O'Sullivan, Joerg Graf, Aishwarya Jadhav, David A Lawrence, William T Lee, Kyle J Carson, Justin D Radolf, Juan C Salazar, Michael A Lynes
March 31, 2023

Multisystem inflammatory syndrome in children (MIS-C) is a rare but serious condition that can develop 4-6 weeks after a school age child becomes infected by SARS-CoV-2. To date, in the…