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COVID-19 Network of Networks Expanding Clinical and Translational Approaches to Predict Severe Illness in Children (CONNECT to Predict Sick Children)

Robert Wood Johnson Medical School

Lawrence Kleinman

PreVAIL kIds
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Neurologic Involvement in Children and Adolescents Hospitalized in the United States for COVID-19 or Multisystem Inflammatory Syndrome.

Written by Kerri L LaRovere, Becky J Riggs, Tina Y Poussaint, Cameron C Young, Margaret M Newhams, Mia Maamari, Tracie C Walker, Aalok R Singh, Heda Dapul, Charlotte V Hobbs, Gwenn E McLaughlin, Mary Beth F Son, Aline B Maddux, Katharine N Clouser, Courtney M Rowan, John K McGuire, Julie C Fitzgerald, Shira J Gertz, Steven L Shein, Alvaro Coronado Munoz, Neal J Thomas, Katherine Irby, Emily R Levy, Mary A Staat, Mark W Tenforde, Leora R Feldstein, Natasha B Halasa, John S Giuliano, Mark W Hall, Michele Kong, Christopher L Carroll, Jennifer E Schuster, Sule Doymaz, Laura L Loftis, Keiko M Tarquinio, Christopher J Babbitt, Ryan A Nofziger, Lawrence C Kleinman, Michael A Keenaghan, Natalie Z Cvijanovich, Philip C Spinella, Janet R Hume, Kari Wellnitz, Elizabeth H Mack, Kelly N Michelson, Heidi R Flori, Manish M Patel, Adrienne G Randolph
May 1, 2021

Importance: Coronavirus disease 2019 (COVID-19) affects the nervous system in adult patients. The spectrum of neurologic involvement in children and adolescents is unclear. Objective: To understand the range and severity…

Multisystem Inflammatory Syndrome in U.S. Children and Adolescents.

Written by Leora R Feldstein, Erica B Rose, Steven M Horwitz, Jennifer P Collins, Margaret M Newhams, Mary Beth F Son, Jane W Newburger, Lawrence C Kleinman, Sabrina M Heidemann, Amarilis A Martin, Aalok R Singh, Simon Li, Keiko M Tarquinio, Preeti Jaggi, Matthew E Oster, Sheemon P Zackai, Jennifer Gillen, Adam J Ratner, Rowan F Walsh, Julie C Fitzgerald, Michael A Keenaghan, Hussam Alharash, Sule Doymaz, Katharine N Clouser, John S Giuliano, Anjali Gupta, Robert M Parker, Aline B Maddux, Vinod Havalad, Stacy Ramsingh, Hulya Bukulmez, Tamara T Bradford, Lincoln S Smith, Mark W Tenforde, Christopher L Carroll, Becky J Riggs, Shira J Gertz, Ariel Daube, Amanda Lansell, Alvaro Coronado Munoz, Charlotte V Hobbs, Kimberly L Marohn, Natasha B Halasa, Manish M Patel, Adrienne G Randolph
July 23, 2020

BACKGROUND: Understanding the epidemiology and clinical course of multisystem inflammatory syndrome in children (MIS-C) and its temporal association with coronavirus disease 2019 (Covid-19) is important, given the clinical and public…

Characteristics and Outcomes of Children With Coronavirus Disease 2019 (COVID-19) Infection Admitted to US and Canadian Pediatric Intensive Care Units.

Written by Lara S Shekerdemian, Nabihah R Mahmood, Katie K Wolfe, Becky J Riggs, Catherine E Ross, Christine A McKiernan, Sabrina M Heidemann, Lawrence C Kleinman, Anita I Sen, Mark W Hall, Margaret A Priestley, John K McGuire, Konstantinos Boukas, Matthew P Sharron, Jeffrey P Burns
September 1, 2020

IMPORTANCE: The recent and ongoing coronavirus disease 2019 (COVID-19) pandemic has taken an unprecedented toll on adults critically ill with COVID-19 infection. While there is evidence that the burden of…

Incidence of Multisystem Inflammatory Syndrome in Children Among US Persons Infected With SARS-CoV-2.

Written by Amanda B Payne, Zunera Gilani, Shana Godfred-Cato, Ermias D Belay, Leora R Feldstein, Manish M Patel, Adrienne G Randolph, Margaret Newhams, Deepam Thomas, Reed Magleby, Katherine Hsu, Meagan Burns, Elizabeth Dufort, Angie Maxted, Michael Pietrowski, Allison Longenberger, Sally Bidol, Justin Henderson, Lynn Sosa, Alexandra Edmundson, Melissa Tobin-D'Angelo, Laura Edison, Sabrina Heidemann, Aalok R Singh, John S Giuliano, Lawrence C Kleinman, Keiko M Tarquinio, Rowan F Walsh, Julie C Fitzgerald, Katharine N Clouser, Shira J Gertz, Ryan W Carroll, Christopher L Carroll, Brooke E Hoots, Carrie Reed, F Scott Dahlgren, Matthew E Oster, Timmy J Pierce, Aaron T Curns, Gayle E Langley, Angela P Campbell, Neha Balachandran, Thomas S Murray, Cole Burkholder, Troy Brancard, Jenna Lifshitz, Dylan Leach, Ian Charpie, Cory Tice, Susan E Coffin, Dana Perella, Kaitlin Jones, Kimberly L Marohn, Phoebe H Yager, Neil D Fernandes, Heidi R Flori, Monica L Koncicki, Karen S Walker, Maria Cecilia Di Pentima, Simon Li, Steven M Horwitz, Sunanda Gaur, Dennis C Coffey, Ilana Harwayne-Gidansky, Saul R Hymes, Neal J Thomas, Kate G Ackerman, Jill M Cholette
June 1, 2021

Importance: Multisystem inflammatory syndrome in children (MIS-C) is associated with recent or current SARS-CoV-2 infection. Information on MIS-C incidence is limited. Objective: To estimate population-based MIS-C incidence per 1 000…

Trends in Disease Severity Among Critically Ill Children With Severe Acute Respiratory Syndrome Coronavirus 2: A Retrospective Multicenter Cohort Study in the United States.

Written by Catherine E Ross, Jeffrey P Burns, Anne V Grossestreuer, Pallav Bhattarai, Christine A McKiernan, Jennifer D Franks, Sonja Lehmann, Jill L Sorcher, Matthew P Sharron, Kitman Wai, Haitham Al-Wahab, Konstantinos Boukas, Mark W Hall, George Ru, Anita I Sen, Hariprem R Rajasekhar, Lawrence C Kleinman, John K McGuire, Amy S Arrington, Flor Munoz-Rivas, Christopher M Osborne, Lara S Shekerdemian
January 1, 2023

OBJECTIVES: To describe trends in critical illness from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in children over the course of the COVID-19 pandemic. We hypothesized that PICU admission…

Highly versatile antibody binding assay for the detection of SARS-CoV-2 infection

Written by Pratik Datta, Rahul Ukey, Natalie Bruiners, William Honnen, Mary O Caryannopoulos, Charles Reichman, Alok K Choudhary, Alberta Onyuka, Deborah Handler, Valentina Guerrini, Pankaj Mishra, Hannah K Dewald, Alfred Lardizabal, Leeba Lederer, Aliza L Leiser, Sabiha Hussain, Sugeet K Jagpal, Jared Radbel, Tanaya Bhowmick, Daniel B Horton, Emily S Barrett, Yingda L Xie, Patricia Fitzgerald-Bocarsly, Stanley H Weiss, Melissa Woortman, Heta Parmar, Jason Roy, Maria Gloria Dominguez-Bello, Martin Blaser, Jeffrey L Carson, Reynold A Panettieri, Steven K Libutti, Henry F Raymond, Abraham Pinter, Maria Laura Gennaro
July 14, 2021

Monitoring the burden and spread of infection with the new coronavirus SARS-CoV-2, whether within small communities or in large geographical settings, is of paramount importance for public health purposes. Serology,…

Prevalence of SARS-CoV-2 infection in previously undiagnosed health care workers at the onset of the U.S. COVID-19 epidemic

Written by Emily S Barrett, Daniel B. Horton, Jason Roy, Maria Laura Gennaro, Andrew Brooks, Jay Tischfield, Patricia Greenberg, Tracy Andrews, Sugeet Jagpal, Nancy Reilly, Martin J. Blaser, Jeffrey Carson, Reynold A. Panettieri Jr.
April 24, 2020

ImportanceHealthcare workers are presumed to be at increased risk of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection due to occupational exposure to infected patients. However, no epidemiological study has examined…

Dichotomy between the humoral and cellular responses elicited by mRNA and adenoviral vector vaccines against SARS-CoV-2.

Written by Rahul Ukey, Natalie Bruiners, Hridesh Mishra, Pankaj K Mishra, Deborah McCloskey, Alberta Onyuka, Fei Chen, Abraham Pinter, Daniela Weiskopf, Alessandro Sette, Jason Roy, Sunanda Gaur, Maria Laura Gennaro
January 25, 2022

BACKGROUND: Protection from severe disease and hospitalization by SARS-CoV-2 vaccination has been amply demonstrated by real-world data. However, the rapidly evolving pandemic raises new concerns. One pertains efficacy of adenoviral…

Dichotomy between the humoral and cellular responses elicited by mRNA and adenoviral vector vaccines against SARS-CoV-2.

Written by Rahul Ukey, Natalie Bruiners, Hridesh Mishra, Pankaj K Mishra, Deborah McCluskey, Alberta Onyuka, Fei Chen, Abraham Pinter, Daniela Weiskopf, Alessandro Sette, Jason Roy, Sunanda Gaur, Maria Laura Gennaro
September 21, 2021

Protection from severe disease and hospitalization by SARS-CoV-2 vaccination has been amply demonstrated by real-world data. However, the rapidly evolving pandemic raises new concerns. One pertains efficacy of adenoviral vector-based…

Biologic correlates of beneficial convalescent plasma therapy in a COVID-19 patient reveal disease resolution mechanisms

Written by Natalie Bruiners, Valentina Guerrini, Rahul Ukey, Ryan Dikdan, Jason Yang, Pankaj Kumar Mishra, Alberta Onyuka, Deborah Handler, Joshua Vieth, Mary o Caryannopoulos, Shuang Guo, Maressa Pollen, Abraham Pinter, Sanjay Tyagi, Daniel Feingold, Claire Philipp, Steven Libutti, Maria Laura Gennaro
February 3, 2022

BackgroundWhile the biomarkers of COVID-19 severity have been thoroughly investigated, the key biological dynamics associated with COVID-19 resolution are still insufficiently understood.

Main bodyWe report a case of full resolution…

Prevalence and Correlates of SARS CoV-2 Among a Community-Based Sample Recruited Using Randomized Venue-Based Sampling. Essex County, NJ, 2020.

Written by Henry F Raymond, Pratik Datta, Rahul Ukey, Peng Wang, Richard J Martino, Kristen D Krause, Corey Rosmarin-DeStefano, Abraham Pinter, Perry N Halkitis, Maria L Gennaro
November 8, 2021

Disparities in morbidity and mortality related to COVID-19 based on race and ethnicity have been documented in the USA. However, it is unclear if these disparities also exist at the…

Design and proof of concept for targeted phage-based COVID-19 vaccination strategies with a streamlined cold-free supply chain.

Written by Daniela I Staquicini, Fenny H F Tang, Christopher Markosian, Virginia J Yao, Fernanda I Staquicini, Esteban Dodero-Rojas, Vinícius G Contessoto, Deodate Davis, Paul O'Brien, Nazia Habib, Tracey L Smith, Natalie Bruiners, Richard L Sidman, Maria L Gennaro, Edmund C Lattime, Steven K Libutti, Paul C Whitford, Stephen K Burley, José N Onuchic, Wadih Arap, Renata Pasqualini
July 27, 2021

Development of effective vaccines against coronavirus disease 2019 (COVID-19) is a global imperative. Rapid immunization of the entire human population against a widespread, continually evolving, and highly pathogenic virus is…

Human Immunodeficiency Viruses Pseudotyped with SARS-CoV-2 Spike Proteins Infect a Broad Spectrum of Human Cell Lines through Multiple Entry Mechanisms.

Written by Chuan Xu, Annie Wang, Ke Geng, William Honnen, Xuening Wang, Natalie Bruiners, Sukhwinder Singh, Fortunato Ferrara, Sara D'Angelo, Andrew R M Bradbury, Maria Laura Gennaro, Dongfang Liu, Abraham Pinter, Theresa L Chang
May 21, 2021

Severe acute respiratory syndrome-related coronavirus (SARS-CoV-2), the causative agent of coronavirus disease 19 (COVID-19), enters cells through attachment to the human angiotensin converting enzyme 2 (hACE2) via the receptor-binding domain…

Severe acute respiratory syndrome coronavirus 2 screening to augment dental office and patient safety.

Written by Cecile A Feldman, Janine Fredericks-Younger, Gayathri Subramanian, Maria Laura Gennaro, Modupe O Coker, Daniel H Fine
January 24, 2022

Longitudinal Analysis of Biologic Correlates of COVID-19 Resolution: Case Report.

Written by Natalie Bruiners, Valentina Guerrini, Rahul Ukey, Ryan J Dikdan, Jason H Yang, Pankaj Kumar Mishra, Alberta Onyuka, Deborah Handler, Joshua Vieth, Mary Carayannopoulos, Shuang Guo, Maressa Pollen, Abraham Pinter, Sanjay Tyagi, Daniel Feingold, Claire Philipp, Steven K Libutti, Maria Laura Gennaro
June 15, 2022

While the biomarkers of COVID-19 severity have been thoroughly investigated, the key biological dynamics associated with COVID-19 resolution are still insufficiently understood. We report a case of full resolution of…

The Pragmatic Return to Effective Dental Infection Control through Triage and Testing (PREDICT): Protocol for a Prospective Clinical Study in the National Dental Practice-Based Research Network.

Written by Janine Fredericks-Younger, Daniel H Fine, Gayathri Subramanian, Modupe O Coker, Cyril Meyerowitz, Patricia Ragusa, Veerasathpurush Allareddy, Mary Ann McBurnie, Ellen Funkhouser, Maria L Gennaro, Cecile A Feldman
August 6, 2022

BACKGROUND: Dental practice has been greatly affected by the COVID-19 pandemic. As SARS-COV-2 infection is transmitted by respiratory fluids, dental practice techniques, which include aerosol-generating procedures, can increase the risk…

Researching COVID to enhance recovery (RECOVER) pediatric study protocol: Rationale, objectives and design

Written by Rachel Gross, Tanayott Thaweethai, Erika B. Rosenzweig, James Chan, Lori B. Chibnik, Mine S. Cicek, Amy J. Elliott, Valerie J. Flaherman, Andrea S. Foulkes, Margot Gage Witvliet, Richard Gallagher, Maria Laura Gennaro, Terry L. Jernigan, Elizabeth W. Karlson, Stuart D. Katz, Patricia A. Kinser, Lawrence C. Kleinman, Michelle F. Lamendola-Essel, Joshua D. Milner, Sindhu Mohandas, Praveen C. Mudumbi, Jane W. Newburger, Kyung E. Rhee, Amy L. Salisbury, Jessica N. Snowden, Cheryl R. Stein, Melissa S. Stockwell, Kelan G. Tantisira, Moriah E. Thomason, Dongngan T. Truong, David Warburton, John C. Wood, Shifa Ahmed, Almary Akerlundh, Akram N. Alshawabkeh, Brett R. Anderson, Judy L. Aschner, Andrew M. Atz, Robin L. Aupperle, Fiona C. Baker, Venkataraman Balaraman, Dithi Banerjee, Deanna M. Barch, Arielle Baskin-Sommers, Sultana Bhuiyan, Marie-Abele C. Bind, Amanda L. Bogie, Natalie C. Buchbinder, Elliott Bueler, Hülya Bükülmez, B.J. Casey, Linda Chang, Duncan B. Clark, Rebecca G. Clifton, Katharine N. Clouser, Lesley Cottrell, Kelly Cowan, Viren D'sa, Mirella Dapretto, Soham Dasgupta, Walter Dehority, Kirsten B. Dummer, Matthew D. Elias, Shari Esquenazi-Karonika, Danielle N. Evans, E. Vincent S. Faustino, Alexander G. Fiks, Daniel Forsha, John J. Foxe, Naomi P. Friedman, Greta Fry, Sunanda Gaur, Dylan G. Gee, Kevin M. Gray, Ashraf S. Harahsheh, Andrew C. Heath, Mary M. Heitzeg, Christina M. Hester, Sophia Hill, Laura Hobart-Porter, Travis K.F. Hong, Carol R. Horowitz, Daniel S. Hsia, Matthew Huentelman, Kathy D. Hummel, William G. Iacono, Katherine Irby, Joanna Jacobus, Vanessa L. Jacoby, Pei-Ni Jone, David C. Kaelber, Tyler J. Kasmarcak, Matthew J. Kluko, Jessica S. Kosut, Angela R. Laird, Jeremy Landeo-Gutierrez, Sean M. Lang, Christine L. Larson, Peter Paul C. Lim, Krista M. Lisdahl, Brian W. McCrindle, Russell J. McCulloh, Alan L. Mendelsohn, Torri D. Metz, Lerraughn M. Morgan, Eva M. Müller-Oehring, Erica R. Nahin, Michael C. Neale, Manette Ness-Cochinwala, Sheila M. Nolan, Carlos R. Oliveira, Matthew E. Oster, Ronald M. Payne, Hengameh Raissy, Isabelle G. Randall, Suchitra Rao, Harrison T. Reeder, Johana M. Rosas, Mark W. Russell, Arash A. Sabati, Yamuna Sanil, Alice I. Sato, Michael S. Schechter, Rangaraj Selvarangan, Divya Shakti, Kavita Sharma, Lindsay M. Squeglia, Michelle D. Stevenson, Jacqueline Szmuszkovicz, Maria M. Talavera-Barber, Ronald J. Teufel, Deepika Thacker, Mmekom M. Udosen, Megan R. Warner, Sara E. Watson, Alan Werzberger, Jordan C. Weyer, Marion J. Wood, H. Shonna Yin, William T. Zempsky, Emily Zimmerman, Benard P. Dreyer, - RECOVER Initiative
May 1, 2023

ImportanceThe prevalence, pathophysiology, and long-term outcomes of COVID-19 (post-acute sequelae of SARS-CoV-2 [PASC] or "Long COVID") in children and young adults remain unknown. Studies must address the urgent need to…

Researching COVID to enhance recovery (RECOVER) adult study protocol: Rationale, objectives and design

Written by Leora I. Horwitz, Tanayott Thaweethai, Shari B. Brosnahan, Mine S. Cicek, Megan L. Fitzgerald, Jason D. Goldman, Rachel Hess, S. L. Hodder, Vanessa L. Jacoby, Michael R. Jordan, Jerry A. Krishnan, Adeyinka O. Laiyemo, Torri D. Metz, Lauren Nichols, Rachel E. Patzer, Anisha Sekar, Nora G. Singer, Lauren E. Stiles, Barbara S. Taylor, Shifa Ahmed, Heather A. Algren, Khamal Anglin, Lisa Aponte-Soto, Hassan Ashktorab, Ingrid V. Bassett, Brahmchetna Bedi, Nahid Bhadelia, Christian Bime, Marie-Abele C. Bind, Lora J. Black, Andra L. Blomkalns, Hassan Brim, Mario Castro, James Chan, Alexander W. Charney, Benjamin K. Chen, Li Qing Chen, Peter Chen, David Chestek, Lori B. Chibnik, Dominic C. Chow, Helen Y. Chu, Rebecca G. Clifton, Shelby Collins, Maged M. Costantine, Sushma K. Cribbs, Steven G. Deeks, John D. Dickinson, Sarah E. Donohue, Matthew S. Durstenfeld, Ivette F. Emery, Kristine M. Erlandson, Julio C. Facelli, Rachael Farah-Abraham, Aloke V. Finn, Melinda S. Fischer, Valerie J. Flaherman, Judes Fleurimont, Vivian Fonseca, Emily J. Gallagher, Jennifer C. Gander, Maria Laura Gennaro, Kelly S. Gibson, Minjoung Go, Steven N. Goodman, Joey P. Granger, Frank L. Greenway, John W. Hafner, Jenny E. Han, Michelle S. Harkins, Kristine S.P. Hauser, James R. Heath, Carla R. Hernandez, On Ho, Matthew K. Hoffman, Susan E. Hoover, Carol R. Horowitz, Harvey Hsu, Priscilla Y. Hsue, Brenna L. Hughes, Prasanna Jagannathan, Judith A. James, Janice John, Sarah Jolley, S. E. Judd, Joy J. Juskowich, Diane G. Kanjilal, Elizabeth W. Karlson, Stuart D. Katz, J. Daniel Kelly, Sara W. Kelly, Arthur Y. Kim, John P. Kirwan, Kenneth S. Knox, Andre Kumar, Michelle F. Lamendola-Essel, Margaret Lanca, Joyce K. Lee-lannotti, R. Craig Lefebvre, Bruce D. Levy, Janet Y. Lin, Brian P. Logarbo Jr., Jennifer K. Logue, Michele T. Longo, Carlos A. Luciano, Karen Lutrick, Shahdi K. Malakooti, Gail Mallett, Gabrielle Maranga, Jai G. Marathe, Vincent C. Marconi, Gailen D. Marshall, Christopher F. Martin, Jeffrey N. Martin, Heidi T. May, Grace A. McComsey, Dylan McDonald, Hector Mendez-Figueroa, Lucio Miele, Murray A. Mittleman, Sindhu Mohandas, Christian Mouchati, Janet M. Mullington, Girish N Nadkarni, Erica R. Nahin, Robert B. Neuman, Lisa T. Newman, Amber Nguyen, Janko Z. Nikolich, Igho Ofotokun, Princess U. Ogbogu, Anna Palatnik, Kristy T.S. Palomares, Tanyalak Parimon, Samuel Parry, Sairam Parthasarathy, Thomas F. Patterson, Ann Pearman, Michael J. Peluso, Priscilla Pemu, Christian M. Pettker, Beth A. Plunkett, Kristen Pogreba-Brown, Athena Poppas, J. Zachary Porterfield, John G. Quigley, Davin K. Quinn, Hengameh Raissy, Candida J. Rebello, Uma M. Reddy, Rebecca Reece, Harrison T. Reeder, Franz P. Rischard, Johana M. Rosas, Clifford J. Rosen, Nadine G. Rouphae, Dwight J. Rouse, Adam M. Ruff, Christina Saint Jean, Grecio J. Sandoval, Jorge L. Santana, Shannon M. Schlater, Frank C. Sciurba, Caitlin Selvaggi, Sudha Seshadri, Howard D. Sesso, Dimpy P. Shah, Eyal Shemesh, Zaki A. Sherif, Daniel J. Shinnick, Hyagriv N. Simhan, Upinder Singh, Amber Sowles, Vignesh Subbian, Jun Sun, Mehul S. Suthar, Larissa J. Teunis, John M. Thorp Jr., Amberly Ticotsky, Alan T. N. Tita, Robin Tragus, Katherine R. Tuttle, Alfredo E. Urdaneta, P. J. Utz, Timothy M. VanWagoner, Andrew Vasey, Suzanne D. Vernon, Crystal Vidal, Tiffany Walker, Honorine D. Ward, David E. Warren, Ryan M. Weeks, Steven J. Weiner, Jordan C. Weyer, Jennifer L. Wheeler, Sidney W. Whiteheart, Zanthia Wiley, Natasha J. Williams, Juan P. Wisnivesky, John C. Wood, Lynn M. Yee, Natalie M. Young, Sokratis N. Zisis, Andrea S. Foulkes, - Recover Initiative
May 28, 2023

ImportanceSARS-CoV-2 infection can result in ongoing, relapsing, or new symptoms or other health effects after the acute phase of infection; termed post-acute sequelae of SARS-CoV-2 infection (PASC), or long COVID.…

Risk Factors for Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Hospital Workers: Results From a Screening Study in New Jersey, United States in Spring 2020.

Written by Emily S Barrett, Daniel B Horton, Jason Roy, Weiyi Xia, Patricia Greenberg, Tracy Andrews, Maria Laura Gennaro, Veenat Parmar, William D Russell, Nancy Reilly, Priyanka Uprety, John J Gantner, Lydia Stockman, Stanley Z Trooskin, Martin J Blaser, Jeffrey L Carson, Reynold A Panettieri
October 31, 2020

BACKGROUND: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is a critical concern among healthcare workers (HCWs). Other studies have assessed SARS-CoV-2 virus and antibodies in HCWs, with disparate findings…

Detection of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Is Comparable in Clinical Samples Preserved in Saline or Viral Transport Medium.

Written by Jared Radbel, Sugeet Jagpal, Jason Roy, Andrew Brooks, Jay Tischfield, Michael Sheldon, Christian Bixby, Dana Witt, Maria L Gennaro, Daniel B Horton, Emily S Barrett, Jeffrey L Carson, Reynold A Panettieri, Martin J Blaser
May 13, 2020

As the coronavirus disease 2019 (COVID-19) pandemic sweeps across the world, the availability of viral transport medium (VTM) has become severely limited, contributing to delays in diagnosis and rationing of…

Highly versatile antibody binding assay for the detection of SARS-CoV-2 infection and vaccination.

Written by Pratik Datta, Rahul Ukey, Natalie Bruiners, William Honnen, Mary O Carayannopoulos, Charles Reichman, Alok Choudhary, Alberta Onyuka, Deborah Handler, Valentina Guerrini, Pankaj K Mishra, Hannah K Dewald, Alfred Lardizabal, Leeba Lederer, Aliza L Leiser, Sabiha Hussain, Sugeet K Jagpal, Jared Radbel, Tanaya Bhowmick, Daniel B Horton, Emily S Barrett, Yingda L Xie, Patricia Fitzgerald-Bocarsly, Stanley H Weiss, Melissa Woortman, Heta Parmar, Jason Roy, Maria Gloria Dominguez-Bello, Martin J Blaser, Jeffrey L Carson, Reynold A Panettieri, Steven K Libutti, Henry F Raymond, Abraham Pinter, Maria Laura Gennaro
October 9, 2021

Monitoring the burden and spread of infection with the new coronavirus SARS-CoV-2, whether within small communities or in large geographical settings, is of paramount importance for public health purposes. Serology,…

Determinants and Dynamics of SARS-CoV-2 Infection in a Diverse Population: 6-Month Evaluation of a Prospective Cohort Study.

Written by Daniel B Horton, Emily S Barrett, Jason Roy, Maria Laura Gennaro, Tracy Andrews, Patricia Greenberg, Natalie Bruiners, Pratik Datta, Rahul Ukey, Senthil K Velusamy, Daniel Fine, William J Honnen, Yue Sandra Yin, Abraham Pinter, Andrew Brooks, Jay Tischfield, Sabiha Hussain, Sugeet Jagpal, Shobha Swaminathan, Veenat Parmar, Nancy Reilly, Sunanda Gaur, Reynold A Panettieri, Jeffrey L Carson, Martin J Blaser
October 28, 2021

BACKGROUND: We studied risk factors, antibodies, and symptoms of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in a diverse, ambulatory population. METHODS: A prospective cohort (n = 831) previously…

Prevalence of SARS-CoV-2 infection in previously undiagnosed health care workers in New Jersey, at the onset of the U.S. COVID-19 pandemic.

Written by Emily S Barrett, Daniel B Horton, Jason Roy, Maria Laura Gennaro, Andrew Brooks, Jay Tischfield, Patricia Greenberg, Tracy Andrews, Sugeet Jagpal, Nancy Reilly, Jeffrey L Carson, Martin J Blaser, Reynold A Panettieri
November 16, 2020

BACKGROUND: Healthcare workers (HCW) are presumed to be at increased risk of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection due to occupational exposure to infected patients. However, there has been…

Acute respiratory distress syndrome and COVID-19 in a child with systemic lupus erythematosus.

Written by Simone Sukhdeo, Emily Negroponte, Hariprem Rajasekhar, Sunanda Gaur, Daniel B Horton, Amisha Malhotra, L Nandini Moorthy
January 28, 2021

We report a case of COVID-19 in a pediatric patient with systemic lupus erythematosus (SLE), who presented with respiratory distress marked by increased work of breathing and low oxygen saturation.…

Asthma and COVID: What Are the Important Questions?

Written by Reynold A Panettieri, Jeffrey Carson, Daniel Horton, Emily Barrett, Jason Roy, Jared Radbel
June 22, 2020

Coronavirus disease 2019 (COVID-19) mortality and neighborhood characteristics in Chicago.

Written by Molly Scannell Bryan, Jiehuan Sun, Jyotsna Jagai, Daniel E Horton, Anastasia Montgomery, Robert Sargis, Maria Argos
November 10, 2020

PURPOSE: To describe coronavirus disease 2019 (COVID-19) mortality in Chicago during the spring of 2020 and identify at the census-tract level neighborhood characteristics that were associated with higher COVID-19 mortality…

Guidelines for Modeling and Reporting Health Effects of Climate Change Mitigation Actions.

Written by Jeremy J Hess, Nikhil Ranadive, Chris Boyer, Lukasz Aleksandrowicz, Susan C Anenberg, Kristin Aunan, Kristine Belesova, Michelle L Bell, Sam Bickersteth, Kathryn Bowen, Marci Burden, Diarmid Campbell-Lendrum, Elizabeth Carlton, Guéladio Cissé, Francois Cohen, Hancheng Dai, Alan David Dangour, Purnamita Dasgupta, Howard Frumkin, Peng Gong, Robert J Gould, Andy Haines, Simon Hales, Ian Hamilton, Tomoko Hasegawa, Masahiro Hashizume, Yasushi Honda, Daniel E Horton, Alexandra Karambelas, Ho Kim, Satbyul Estella Kim, Patrick L Kinney, Inza Kone, Kim Knowlton, Jos Lelieveld, Vijay S Limaye, Qiyong Liu, Lina Madaniyazi, Micaela Elvira Martinez, Denise L Mauzerall, James Milner, Tara Neville, Mark Nieuwenhuijsen, Shonali Pachauri, Frederica Perera, Helen Pineo, Justin V Remais, Rebecca K Saari, Jon Sampedro, Pauline Scheelbeek, Joel Schwartz, Drew Shindell, Priya Shyamsundar, Timothy J Taylor, Cathryn Tonne, Detlef Van Vuuren, Can Wang, Nicholas Watts, J Jason West, Paul Wilkinson, Stephen A Wood, James Woodcock, Alistair Woodward, Yang Xie, Ying Zhang, Kristie L Ebi
November 10, 2020

BACKGROUND: Modeling suggests that climate change mitigation actions can have substantial human health benefits that accrue quickly and locally. Documenting the benefits can help drive more ambitious and health-protective climate…

Community- Versus Health Care Organization-Based Approaches to Expanding At-Home COVID-19 Testing in Black and Latino Communities, New Jersey, 2021.

Written by Emily S Barrett, Tracy R Andrews, Jason Roy, Patricia Greenberg, Jeanne M Ferrante, Daniel B Horton, Marsha Gordon, Zorimar Rivera-Núñez, Maria B Pellerano, Alfred F Tallia, Mark Budolfson, Panos Georgopoulos, Dorothy Reed, Beverly Lynn, Robert Rosati, Manuel Castañeda, Francis Dixon, Chris Pernell, Diane Hill, Manuel E Jimenez, Martin J Blaser, Reynold Panettieri, Shawna V Hudson
October 20, 2022

At-home COVID-19 testing offers convenience and safety advantages. We evaluated at-home testing in Black and Latino communities through an intervention comparing community-based organization (CBO) and health care organization (HCO) outreach.…

Neutralizing antibody activity against 21 SARS-CoV-2 variants in older adults vaccinated with BNT162b2.

Written by Joseph Newman, Nazia Thakur, Thomas P Peacock, Dagmara Bialy, Ahmed M E Elrefaey, Carlijn Bogaardt, Daniel L Horton, Sammy Ho, Thivya Kankeyan, Christine Carr, Katja Hoschler, Wendy S Barclay, Gayatri Amirthalingam, Kevin E Brown, Bryan Charleston, Dalan Bailey
July 14, 2022

SARS-CoV-2 variants may threaten the effectiveness of vaccines and antivirals to mitigate serious COVID-19 disease. This is of most concern in clinically vulnerable groups such as older adults. We analysed…

Childhood asthma diagnoses declined during the COVID-19 pandemic in the United States.

Written by Daniel B Horton, Amanda L Neikirk, Yiling Yang, Cecilia Huang, Reynold A Panettieri, Stephen Crystal, Brian L Strom, Lauren E Parlett
March 10, 2023

BACKGROUND: Prior studies have documented declines in pediatric asthma exacerbations and asthma-related health care utilization during the COVID-19 pandemic, but less is known about the incidence of asthma during the…

Geographic Trends in Pediatric Psychotropic Medication Dispensing Before and After the Startof the COVID-19 Pandemic.

Written by Greta Bushnell, Jenny W Sun, Susan dosReis, Wendy Camelo Castillo, Angela S Czaja, Geneviève Durrieu, Tobias Gerhard, Haeyoung Lee, Florentia Kaguelidou, Sangita Pudasainee-Kapri, Sudha R Raman, O'Mareen Spence, Daniel B Horton
February 8, 2023

OBJECTIVE: This study examined trends and geographic variability in dispensing of prescription psychotropic medications to U.S. youths before and after the start of the COVID-19 pandemic. METHODS: Using national data…