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AICORE-kids: Artificial Intelligence COVID-19 Risk AssEssment for kids

Baylor College Of Medicine

Ananth Annapragada

PreVAIL kIds
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Acute appendicitis and SARS-CoV-2 in children: imaging findings at a tertiary children's hospital during the COVID-19 pandemic.

Written by Rida Salman, Andrew C Sher, R Paul Guillerman, Victor J Seghers, J Ruben Rodriguez, Haleh Sangi-Haghpeykar, Ananth V Annapragada, Marla B K Sammer
November 5, 2021

BACKGROUND: Evidence suggests severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection may be associated with appendicitis or clinical symptoms that mimic appendicitis, but it is not clear if the findings…

Population stratification enables modeling effects of reopening policies on mortality and hospitalization rates.

Written by Tongtong Huang, Yan Chu, Shayan Shams, Yejin Kim, Ananth V Annapragada, Devika Subramanian, Ioannis Kakadiaris, Assaf Gottlieb, Xiaoqian Jiang
May 20, 2021

OBJECTIVE: Study the impact of local policies on near-future hospitalization and mortality rates. MATERIALS AND METHODS: We introduce a novel risk-stratified SIR-HCD model that introduces new variables to model the…

Lower skeletal muscle mass on CT body composition analysis is associated with adverse clinical course and outcome in children with COVID-19.

Written by Rida Salman, Marla B Sammer, Bettina L Serrallach, Haleh Sangi-Haghpeykar, Ananth V Annapragada, R Paul Guillerman
February 21, 2022

OBJECTIVES: To assess the association between body composition measures in children with COVID-19 and severity of the disease course and clinical outcome. METHODS: A retrospective study of children (

Social and Demographic Disparities in the Severity of Multisystem Inflammatory Syndrome in Children.

Written by Fabio Savorgnan, Sebastian Acosta, Alexander Alali, Axel Moreira, Ananth Annapragada, Craig G Rusin, Saul Flores, Rohit S Loomba, Alvaro Moreira
June 1, 2022

Social constructs are known risk factors for multisystem inflammatory syndrome in children. A review of 206 patients demonstrated that children who were non-Hispanic Black, over the age of 12 years…

Comparison of Laboratory and Hemodynamic Time Series Data Across Original, Alpha, and Delta Variants in Patients With Multisystem Inflammatory Syndrome in Children.

Written by Parag N Jain, Sebastian Acosta, Ananth Annapragada, Paul A Checchia, Axel Moreira, Eyal Muscal, Sarah E Sartain, S Kristen Sexson Tejtel, Tiphanie P Vogel, Lara Shekerdemian, Craig G Rusin
May 4, 2022

OBJECTIVES: To compare the clinical, laboratory, and hemodynamic parameters during hospitalization for patients with multisystem inflammatory syndrome in children (MIS-C), across the Original/Alpha and the Delta variants of severe acute…

Physiologic profile associated with severe multisystem inflammatory syndrome in children: a retrospective study.

Written by Fabio Savorgnan, Alvaro Moreira, Axel Moreira, Ananth Annapragada, S Kristen Sexson Tejtel, Saul Flores, Craig G Rusin, Lara Shekerdemian, Sebastian Acosta
May 14, 2022

OBJECTIVE: The purpose of this study was to describe the clinical presentation and physiologic profile of individuals with varying degrees of severity of multisystem inflammatory syndrome in children (MIS-C). METHODS:…

Association of Area Deprivation Index With Severity of COVID-19 in Pediatric Patients: A Multisite Study of Racially and Ethnically Diverse Children.

Written by Sebastian Acosta, Srinivasan Suresh, Anna K Ettinger, Fabio Savorgnan, Ananth Annapragada, Nirupama Kannikeswaran, Usha Sethuraman
February 22, 2023

Area deprivation index (ADI) is associated with the risk of severe COVID-19 in adults. However, this association has not been established in children. Information on ADI, demographics, clinical features, disease…

Clinical performance of a semi-quantitative assay for SARS-CoV2 IgG and SARS-CoV2 IgM antibodies.

Written by Joanna Jung, Emily Garnett, Purviben Jariwala, Hue Pham, Rongrong Huang, Eduardo Benzi, Niveen Issaq, Martin Matzuk, Ila Singh, Sridevi Devaraj
September 19, 2020

BACKGROUND: While the diagnosis of SARS-CoV-2 infection is primarily based on detection of viral RNA, the detection of SARS-CoV-2 antibodies is useful for assessing past prevalence of the disease, and…

Analytical and clinical performance of cPass neutralizing antibodies assay.

Written by Joanna Jung, Deepthi Rajapakshe, Christopher Julien, Sridevi Devaraj
September 21, 2021

Serological tests for SARS-CoV-2 are a critical component of disease control strategies. SARS-CoV-2 serology tests used in clinical diagnostic should not accurately evaluate total levels the antibodies but also closely…

Defining the Cytokine Storm Syndrome of COVID-19: Role of the Clinical Laboratory.

Written by Ishwarlal Jialal, Sridevi Devaraj

COVID-19 in Pediatrics: A Laboratory Perspective.

Written by Jing Cao, Sridevi Devaraj
July 1, 2020

Clinical Validation and Performance Evaluation of the Automated Vitros Total Anti-SARS-CoV-2 Antibodies Assay for Screening of Serostatus in COVID-19.

Written by Emily Garnett, Joanna Jung, Estella Tam, Deepthi Rajapakshe, Stephen Cheney, Cameron Brown, Jing Cao, Kenneth Muldrew, Ila Singh, James Versalovic, Sridevi Devaraj
November 4, 2020

OBJECTIVES: Evaluation of serostatus against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has emerged as an important tool in identification of exposure to coronavirus disease 2019 (COVID-19). We report on…

Pandemic-Associated Trends in Measurement of HbA1c in Children with Diabetes Mellitus and Validation of Dried Blood Spot as an Alternative Sample Matrix.

Written by Emily R Garnett, Brandy Recio, Joanna Jung, Estella Tam, Sridevi Devaraj

OBJECTIVE: Routine monitoring of hemoglobin A1c (HbA1c) is the standard of care in diabetes mellitus (DM), but adhering to regular laboratory appointments may be challenging when access to care is…

Clinical validation and performance evaluation of the automated Vitros Total Anti-SARS-CoV-2 Antibodies assay for screening of serostatus in COVID-19

Written by Emily Garnett, Joanna Jung, Estella Tam, Deepthi Rajapakshe, Stephen Cheney, Cameron Brown, Kenneth L Muldrew, Jing Cao, Ila Singh, James Versalovic, Sridevi Devaraj
June 12, 2020

ObjectivesEvaluation of serostatus against SARS-CoV-2 has emerged as an important tool in identification of exposure to COVID-19. We report on the validation of the Vitros Anti-SARS-CoV-2 Total (CoV2T) assay for…

Evaluation of SARS-CoV-2 Serological Testing in Patients with Multiple Myeloma and Other Hematologic Malignancies on Monoclonal Antibody Therapies.

Written by Lenin Mahimainathan, Madhusudhanan Narasimhan, Rolando Corchado, Hetalkumari Patel, Ankit Kansagra, Sridevi Devaraj, Praveen Ramakrishnan Geethakumari, Alagarraju Muthukumar
November 24, 2020

BACKGROUND: Patients with hematological malignancies (HM), including multiple myeloma (MM), frequently suffer from immune deficiency-associated infectious complications because of both the disease and the treatment. Alarming results from China and…

SARS-CoV-2 anti-spike antibodies after vaccination in pediatric heart transplantation: A first report.

Written by Joseph A Spinner, Christopher L Julien, Lily Olayinka, William J Dreyer, Claire E Bocchini, Flor M Munoz, Sridevi Devaraj
November 14, 2021

BACKGROUND: BACKGROUND: There is a paucity of data regarding the antibody response to SARS-CoV-2 vaccination in children after solid organ transplant. METHODS: We retrospectively reviewed the SARS-CoV-2 Anti-Spike IgG antibodies…

SARSCoV-2 serostatus amongst vaccinated employees at a pediatric hospital system.

Written by Sridevi Devaraj, Izmarie Poventud-Fuentes, Matthew Girotto, Jermaine Monroe, Julie Boom, George Delclos, James Versalovic
December 26, 2021

To gain insights on the heterogeneity of immune responses to vaccination against SARS-CoV-2 and to identify factors that could make individuals vulnerable to infection due to lack of response to…

Misleading nomenclature of units of WHO materials used for standardization of SARS COv-2 serology.

Written by Young Bae Lee Hansen, Koh Furuta, Sridevi Devaraj, Fatma Meric Yilmaz, Gunnar Nordin
June 27, 2022

Convalescent plasma in hospitalized pediatric and obstetric COVID-19 patients.

Written by Saki Ikeda, Eduardo Benzi, Lisa A Hensch, Sridevi Devaraj, Shiu-Ki Hui, Manisha Gandhi, Karin A Fox, Jun Teruya, Flor M Munoz
November 3, 2022

BACKGROUND: Published data on COVID-19 convalescent plasma (CCP) use in children and obstetric patients are limited. We describe a single-center experience of hospitalized patients who received CCP for acute COVID-19.…

Abnormalities in cardiac and inflammatory biomarkers in ambulatory subjects after COVID-19 infection.

Written by Joshua A Keefe, Vasanthi Avadhanula, Erin G Nicholson, Sridevi Devaraj, Pedro A Piedra, Biykem Bozkurt, Xander H T Wehrens
October 28, 2022

Background: Coronavirus-2019 (COVID-19) is known to affect the heart and is associated with a pro-inflammatory state. Most studies to date have focused on clinically sick subjects. Here, we report cardiac…

Stratification of Pediatric COVID-19 cases by inflammatory biomarker profiling and machine learning

Written by Devika Subramanian, Aadith Vittala, Xinpu Chen, Christopher Julien, Sebastian Acosta, Craig Rusin, Carl Allen, Nicholas Rider, Zbigniew Starosolski, Ananth A Annapragada, Sridevi Devaraj
April 4, 2023

An objective method to identify imminent or current Multi-Inflammatory Syndrome in Children (MIS-C) infected with SARS-CoV-2 is highly desirable. The aims was to define an algorithmically interpreted novel cytokine/chemokine assay…

Visualizing and assessing US county-level COVID19 vulnerability.

Written by Gina Cahill, Carleigh Kutac, Nicholas L Rider
December 19, 2020

BACKGROUND: Like most of the world, the United States' public health and economy are impacted by the COVID19 pandemic. However, discrete pandemic effects may not be fully realized on the…

Reply to "Subcutaneous terbutaline as an alternative to aerosolized albuterol".

Written by Marcus S Shaker, John Oppenheimer, Mitchell Grayson, David Stukus, Nicholas Hartog, Elena W Y Hsieh, Nicholas Rider, Cullen M Dutmer, Timothy K Vander Leek, Harold Kim, Edmond S Chan, Doug Mack, Anne K Ellis, David Lang, Jay Lieberman, David Fleischer, David B K Golden, Dana Wallace, Jay Portnoy, Giselle Mosnaim, Matthew Greenhawt
April 22, 2020

A Phased Approach to Resuming Suspended Allergy/Immunology Clinical Services.

Written by Daniel A Searing, Cullen M Dutmer, David M Fleischer, Marcus S Shaker, John Oppenheimer, Mitchell H Grayson, David Stukus, Nicholas Hartog, Elena W Y Hsieh, Nicholas L Rider, Timothy K Vander Leek, Harold Kim, Edmond S Chan, Doug Mack, Anne K Ellis, Elissa M Abrams, Priya Bansal, David M Lang, Jay Lieberman, David Bk Golden, Dana Wallace, Jay Portnoy, Giselle Mosnaim, Matthew Greenhawt
May 22, 2020

In early 2020, the first US and Canadian cases of the novel severe acute respiratory syndrome coronavirus 2 infection were detected. In the ensuing months, there has been rapid spread…

COVID-19: Pandemic Contingency Planning for the Allergy and Immunology Clinic.

Written by Marcus S Shaker, John Oppenheimer, Mitchell Grayson, David Stukus, Nicholas Hartog, Elena W Y Hsieh, Nicholas Rider, Cullen M Dutmer, Timothy K Vander Leek, Harold Kim, Edmond S Chan, Doug Mack, Anne K Ellis, David Lang, Jay Lieberman, David Fleischer, David B K Golden, Dana Wallace, Jay Portnoy, Giselle Mosnaim, Matthew Greenhawt
March 26, 2020

In the event of a global infectious pandemic, drastic measures may be needed that limit or require adjustment of ambulatory allergy services. However, no rationale for how to prioritize service…

The arrival of SARS-CoV-2-neutralizing antibodies in a currently available commercial immunoglobulin.

Written by Aaron L Miller, Nicholas L Rider, Richard B Pyles, Barbara Judy, Xuping Xie, Pei-Yong Shi, Thomas G Ksiazek
April 21, 2022