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Robert Schooley, MD

University of California, San Diego

Co Investigator: Diagnostic Strategy and Network lead

Diagnostic developmentVirology
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Related publications

1-O-Octadecyl-2-O-benzyl-sn-glyceryl-3-phospho-GS-441524 (V2043). Evaluation of Oral V2043 in a Mouse Model of SARS-CoV-2 Infection and Synthesis and Antiviral Evaluation of Additional Phospholipid Esters with Enhanced Anti-SARS-CoV-2 Activity.

Aaron F Carlin, James R Beadle, Alex E Clark, Kendra L Gully, Fernando R Moreira, Ralph S Baric, Rachel L Graham, Nadejda Valiaeva, Sandra L Leibel, William Bray, Rachel E McMillan, Jonathan E Freshman, Aaron F Garretson, Rachael N McVicar, Tariq Rana, Xing-Quan Zhang, Joyce A Murphy, Robert T Schooley, Karl Y Hostetler
April 11, 2023

Early antiviral treatments, including intravenous remdesivir (RDV), reduce hospitalization and severe disease caused by COVID-19. An orally bioavailable RDV analog may facilitate earlier treatment of non-hospitalized COVID-19 patients. Here we…

Cancer, more than a "COVID-19 co-morbidity".

Chinmay T Jani, Robert T Schooley, Rana R Mckay, Scott M Lippman
March 13, 2023

Patients with cancer represent a particularly vulnerable population at risk of adverse outcomes related to COVID-19. Collectively, the initial studies, including patients with and without cancer, confirmed that patients with…

Wastewater sequencing reveals early cryptic SARS-CoV-2 variant transmission.

Smruthi Karthikeyan, Joshua I Levy, Peter De Hoff, Greg Humphrey, Amanda Birmingham, Kristen Jepsen, Sawyer Farmer, Helena M Tubb, Tommy Valles, Caitlin E Tribelhorn, Rebecca Tsai, Stefan Aigner, Shashank Sathe, Niema Moshiri, Benjamin Henson, Adam M Mark, Abbas Hakim, Nathan A Baer, Tom Barber, Pedro Belda-Ferre, Marisol Chacón, Willi Cheung, Evelyn S Cresini, Emily R Eisner, Alma L Lastrella, Elijah S Lawrence, Clarisse A Marotz, Toan T Ngo, Tyler Ostrander, Ashley Plascencia, Rodolfo A Salido, Phoebe Seaver, Elizabeth W Smoot, Daniel McDonald, Robert M Neuhard, Angela L Scioscia, Alysson M Satterlund, Elizabeth H Simmons, Dismas B Abelman, David Brenner, Judith C Bruner, Anne Buckley, Michael Ellison, Jeffrey Gattas, Steven L Gonias, Matt Hale, Faith Hawkins, Lydia Ikeda, Hemlata Jhaveri, Ted Johnson, Vince Kellen, Brendan Kremer, Gary Matthews, Ronald W McLawhon, Pierre Ouillet, Daniel Park, Allorah Pradenas, Sharon Reed, Lindsay Riggs, Alison Sanders, Bradley Sollenberger, Angela Song, Benjamin White, Terri Winbush, Christine M Aceves, Catelyn Anderson, Karthik Gangavarapu, Emory Hufbauer, Ezra Kurzban, Justin Lee, Nathaniel L Matteson, Edyth Parker, Sarah A Perkins, Karthik S Ramesh, Refugio Robles-Sikisaka, Madison A Schwab, Emily Spencer, Shirlee Wohl, Laura Nicholson, Ian H Mchardy, David P Dimmock, Charlotte A Hobbs, Omid Bakhtar, Aaron Harding, Art Mendoza, Alexandre Bolze, David Becker, Elizabeth T Cirulli, Magnus Isaksson, Kelly M Schiabor Barrett, Nicole L Washington, John D Malone, Ashleigh Murphy Schafer, Nikos Gurfield, Sarah Stous, Rebecca Fielding-Miller, Richard S Garfein, Tommi Gaines, Cheryl Anderson, Natasha K Martin, Robert Schooley, Brett Austin, Duncan R MacCannell, Stephen F Kingsmore, William Lee, Seema Shah, Eric McDonald, Alexander T Yu, Mark Zeller, Kathleen M Fisch, Christopher Longhurst, Patty Maysent, David Pride, Pradeep K Khosla, Louise C Laurent, Gene W Yeo, Kristian G Andersen, Rob Knight
July 7, 2022

As SARS-CoV-2 continues to spread and evolve, detecting emerging variants early is critical for public health interventions. Inferring lineage prevalence by clinical testing is infeasible at scale, especially in areas…

Transmission of SARS-CoV-2: still up in the air - Authors' reply.

Trisha Greenhalgh, Jose L Jimenez, Kimberly A Prather, Zeynep Tufeki, David Fisman, Robert Schooley
February 5, 2022

Treatment of Coronavirus Disease 2019-Evidence-based or Personalized Medicine?

Ferric C Fang, Robert T Schooley
January 7, 2022

Broad-Spectrum In Vitro Antiviral Activity of ODBG-P-RVn: An Orally-Available, Lipid-Modified Monophosphate Prodrug of Remdesivir Parent Nucleoside (GS-441524).

Michael K Lo, Punya Shrivastava-Ranjan, Payel Chatterjee, Mike Flint, James R Beadle, Nadejda Valiaeva, Joyce Murphy, Robert T Schooley, Karl Y Hostetler, Joel M Montgomery, Christina F Spiropoulou
December 22, 2021

The necessity for intravenous administration of remdesivir confines its utility for treatment of coronavirus disease 2019 (COVID-19) to hospitalized patients. We evaluated the broad-spectrum antiviral activity of ODBG-P-RVn, an orally…

Prevention of Covid-19 with the BNT162b2 and mRNA-1273 Vaccines.

Robert T Schooley
November 4, 2021

Evaluation of Severe Acute Respiratory Syndrome Coronavirus 2 Transmission Mitigation Strategies on a University Campus Using an Agent-Based Network Model.

Ravi Goyal, John Hotchkiss, Robert T Schooley, Victor De Gruttola, Natasha K Martin
November 2, 2021

Universities are faced with decisions on how to resume campus activities while mitigating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) risk. To provide guidance for these decisions, we developed an…

Rethinking Remdesivir: Synthesis, Antiviral Activity, and Pharmacokinetics of Oral Lipid Prodrugs.

Robert T Schooley, Aaron F Carlin, James R Beadle, Nadejda Valiaeva, Xing-Quan Zhang, Alex E Clark, Rachel E McMillan, Sandra L Leibel, Rachael N McVicar, Jialei Xie, Aaron F Garretson, Victoria I Smith, Joyce Murphy, Karl Y Hostetler
September 17, 2021

Remdesivir (RDV; GS-5734) is currently the only FDA-approved antiviral drug for the treatment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The drug is approved for use in adults…

Molecular Mirror Technology Facilitates High-Throughput, Accurate SARS-CoV-2 Testing.

Susan Realegeno, Sara Hash, Charlene Wong, Roland Liu, Jovan Shepherd, Robert T Schooley, David A Lipson, Frederick Fung, Suresh Menon, David T Pride
September 3, 2021

Tests to diagnose acute SARS-CoV-2 infection are at the center of controlling the COVID-19 pandemic. Rapid tests benefit from providing quick results but suffer from lower sensitivity, while PCR tests…

Rapid, Large-Scale Wastewater Surveillance and Automated Reporting System Enable Early Detection of Nearly 85% of COVID-19 Cases on a University Campus.

Smruthi Karthikeyan, Andrew Nguyen, Daniel McDonald, Yijian Zong, Nancy Ronquillo, Junting Ren, Jingjing Zou, Sawyer Farmer, Greg Humphrey, Diana Henderson, Tara Javidi, Karen Messer, Cheryl Anderson, Robert Schooley, Natasha K Martin, Rob Knight
August 31, 2021

Wastewater-based surveillance has gained prominence and come to the forefront as a leading indicator of forecasting COVID-19 (coronavirus disease 2019) infection dynamics owing to its cost-effectiveness and its ability to…

Broad-spectrum in vitro antiviral activity of ODBG-P-RVn: an orally-available, lipid-modified monophosphate prodrug of remdesivir parent nucleoside (GS-441524)

Michael K Lo, Punya Shrivastava-Ranjan, Payel Chatterjee, Mike Flint, James R Beadle, Nadejda Valiaeva, Robert Schooley, Karl Y. Hostetler, Joel Montgomery, Christina F Spiropoulou
August 8, 2021

The intravenous administration of remdesivir for COVID-19 confines its utility to hospitalized patients. We evaluated the broad-spectrum antiviral activity of ODBG-P-RVn, an orally available, lipid-modified monophosphate prodrug of the remdesivir…

Introduction to the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS CoV-2) Supplement.

Robert T Schooley
July 30, 2021

Rapid, large-scale wastewater surveillance and automated reporting system enabled early detection of nearly 85% of COVID-19 cases on a University campus

Smruthi Karthikeyan, Andrew Nguyen, Daniel McDonald, Yijian Zong, Nancy Ronquillo, Junting Ren, Jingjing Zou, Sawyer Farmer, Greg Humphrey, Diana Henderson, Tara Javidi, Karen Messer, Cheryl Anderson, Robert Schooley, Natasha Martin, Rob Knight
June 27, 2021

Wastewater based surveillance has gained prominence and come to the forefront as a leading indicator of forecasting COVID-19 infection dynamics owing to its cost-effectiveness and its ability to inform early…

COVID-19-Lessons Learned and Questions Remaining.

Ferric C Fang, Constance A Benson, Carlos Del Rio, Kathryn M Edwards, Vance G Fowler, David N Fredricks, Ajit P Limaye, Barbara E Murray, Susanna Naggie, Peter G Pappas, Robin Patel, David L Paterson, David A Pegues, William A Petri, Robert T Schooley
June 15, 2021

In this article, the editors of Clinical Infectious Diseases review some of the most important lessons they have learned about the epidemiology, clinical features, diagnosis, treatment and prevention of SARS-CoV-2…

SARS-CoV-2 Infection after Vaccination in Health Care Workers in California.

Jocelyn Keehner, Lucy E Horton, Michael A Pfeffer, Christopher A Longhurst, Robert T Schooley, Judith S Currier, Shira R Abeles, Francesca J Torriani
May 6, 2021

Ten scientific reasons in support of airborne transmission of SARS-CoV-2.

Trisha Greenhalgh, Jose L Jimenez, Kimberly A Prather, Zeynep Tufekci, David Fisman, Robert Schooley
May 1, 2021

Airborne transmission of SARS-CoV-2.

Kimberly A Prather, Linsey C Marr, Robert T Schooley, Melissa A McDiarmid, Mary E Wilson, Donald K Milton
October 16, 2020

Reducing transmission of SARS-CoV-2.

Kimberly A Prather, Chia C Wang, Robert T Schooley
June 26, 2020