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Hua Xu, PhD

The University of Texas Health Science Center of Houston

PI: Data Core lead

data scienceInformaticssoftware development
LinkedIn

Related publications

Aptamer-based nanointerferometer enables amplification-free ultrasensitive detection and differentiation of SARS-CoV-2 variants.

Changtian Chen, Xiaohui Song, Yuanling Yu, Xingwei Wang, Hua Xu, Weiwei Ji, Jingchen Ma, Chenyan Zhao, Silu Feng, Youchun Wang, Xiao-Dong Su, Wei Wang
June 15, 2023

The state-of-the-art SARS-CoV-2 detection methods include qRT-PCR and antibody-based lateral flow assay (LFA) point-of-care tests. Despite the high sensitivity and selectivity, qRT-PCR is slow, expensive and needs well-trained operators. On…

Human antibody BD-218 has broad neutralizing activity against concerning variants of SARS-CoV-2.

Bo Wang, Hua Xu, Zi-Teng Liang, Tian-Ning Zhao, Xin Zhang, Tian-Bo Peng, You-Chun Wang, Xiao-Dong Su
December 14, 2022

As SARS-CoV-2 variants of concern (VOC) reduce the effectiveness of existing anti-COVID therapeutics, it is increasingly critical to identify highly potent neutralizing antibodies (nAbs) that bind to conserved regions across…

Sentiment Analysis of Insomnia-Related Tweets via Combination of Transformers Using Dempster-Shafer Theory: A Pre-Peri COVID-19 Pandemic Retrospective Study.

Arash Maghsoudi, Sara Nowakowski, Ritwick Agrawal, Amir Sharafkhaneh, Mark E Kunik, Aanand D Naik, Hua Xu, Javad Razjouyan
November 15, 2022

BACKGROUND: The COVID-19 pandemic has imposed additional stress on population health that may result in a change of sleeping behavior. OBJECTIVE: In this study, we hypothesized that using natural language…

Factors Associated With COVID-19 Death in the United States: Cohort Study.

Uan-I Chen, Hua Xu, Trudy Millard Krause, Raymond Greenberg, Xiao Dong, Xiaoqian Jiang
May 12, 2022

BACKGROUND: Since the initial COVID-19 cases were identified in the United States in February 2020, the United States has experienced a high incidence of the disease. Understanding the risk factors…

Recurrent neural network models (CovRNN) for predicting outcomes of patients with COVID-19 on admission to hospital: model development and validation using electronic health record data.

Laila Rasmy, Masayuki Nigo, Bijun Sai Kannadath, Ziqian Xie, Bingyu Mao, Khush Patel, Yujia Zhou, Wanheng Zhang, Angela Ross, Hua Xu, Degui Zhi
April 21, 2022

BACKGROUND: Predicting outcomes of patients with COVID-19 at an early stage is crucial for optimised clinical care and resource management, especially during a pandemic. Although multiple machine learning models have…

Combining human and machine intelligence for clinical trial eligibility querying.

Yilu Fang, Betina Idnay, Yingcheng Sun, Hao Liu, Zhehuan Chen, Karen Marder, Hua Xu, Rebecca Schnall, Chunhua Weng
April 15, 2022

OBJECTIVE: To combine machine efficiency and human intelligence for converting complex clinical trial eligibility criteria text into cohort queries. MATERIALS AND METHODS: Criteria2Query (C2Q) 2.0 was developed to enable real-time…

Novel informatics approaches to COVID-19 Research: From methods to applications.

Hua Xu, David L Buckeridge, Fei Wang, Peter Tarczy-Hornoch
February 16, 2022

Factors associated with the time to return negative RT-PCR from COVID-19 in paediatric patients: a retrospective cohort study.

Jianbo Shao, Hong Xu, Zhixi Liu, Xiaohua Ying, Hua Xu, Xianfeng Wang, Jinmiao Lu, Yidie Huang, Guangfei Wang, Yanling He, Jie Chen, Shuli Ma, Shangrong Zou, Yuxia Cui, Ruijie Chen, Jin Lu, Xuyuan Li, Zhiping Li, Guoying Huang, Weibing Wang
October 25, 2021

OBJECTIVE: This study aimed to describe the epidemiological and clinical features and potential factors related to the time to return negative reverse transcriptase (RT)-PCR in discharged paediatric patients with COVID-19.…

CovRNN - A recurrent neural network model for predicting outcomes of COVID-19 patients: model development and validation using EHR data

Laila Rasmy, Masayuki Nigo, Bijun Sai Kannadath, Ziqian Xie, Bingyu Mao, Khush Patel, Yujia Zhou, Wanheng Zhang, Angela M. Ross, Hua Xu, Degui Zhi
September 29, 2021

BackgroundPredicting outcomes of COVID-19 patients at an early stage is critical for optimized clinical care and resource management, especially during a pandemic. Although multiple machine learning models have been proposed…

Comprehensive Characterization of COVID-19 Patients with Repeatedly Positive SARS-CoV-2 Tests Using a Large U.S. Electronic Health Record Database.

Xiao Dong, Yujia Zhou, Xiao-Ou Shu, Elmer V Bernstam, Rebecca Stern, David M Aronoff, Hua Xu, Loren Lipworth
September 3, 2021

In the absence of genome sequencing, two positive molecular tests for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) separated by negative tests, prolonged time, and symptom resolution remain the best…

Structure-based analyses of neutralization antibodies interacting with naturally occurring SARS-CoV-2 RBD variants.

Hua Xu, Bo Wang, Tian-Ning Zhao, Zi-Teng Liang, Tian-Bo Peng, Xiao-Hui Song, Jia-Jing Wu, You-Chun Wang, Xiao-Dong Su
September 3, 2021

Characteristics of emergency room visits in patients with facial injuries in mainland China during the 60-day level I emergency response to COVID-19.

Yi Zhang, Ying Liu, Tingliang Wang, Jiasheng Dong, Hua Xu
August 17, 2021

Chinese mainland launched the 60-day first-level response to major public health emergencies during the COVID-19 outbreak. This study aimed to determine the incidence and describe the characteristics and predictors of…

The application of artificial intelligence and data integration in COVID-19 studies: a scoping review.

Yi Guo, Yahan Zhang, Tianchen Lyu, Mattia Prosperi, Fei Wang, Hua Xu, Jiang Bian
August 13, 2021

OBJECTIVE: To summarize how artificial intelligence (AI) is being applied in COVID-19 research and determine whether these AI applications integrated heterogenous data from different sources for modeling. MATERIALS AND METHODS:…

Dyslipidemia Is Related to Mortality in Critical Patients With Coronavirus Disease 2019: A Retrospective Study.

Jiang Yue, Hua Xu, Yong Zhou, Wen Liu, Xiaofeng Han, Qing Mao, Shengxian Li, Lai-Shan Tam, Jing Ma, Wei Liu
June 23, 2021

Background: It has been reported that dyslipidemia is related to coronavirus-related diseases. Critical patients with coronavirus disease 2019 (COVID-19) who suffered from multiple organ dysfunctions were treated in the intensive…

Comprehensive characterization of COVID-19 patients with repeatedly positive SARS-CoV-2 tests using a large US electronic health record database

Xiao Dong, Yujia Zhou, Xiao-ou Shu, Elmer Bernstam, Rebecca Stern, David Aronoff, Hua Xu, Loren Lipworth
June 13, 2021

BackgroundIn the absence of genome sequencing, two positive molecular SARS-CoV-2 tests separated by negative tests, prolonged time, and symptom resolution remain the best surrogate measure of possible re-infection.

MethodsUsing a…

COVID-19 SignSym: a fast adaptation of a general clinical NLP tool to identify and normalize COVID-19 signs and symptoms to OMOP common data model.

Jingqi Wang, Noor Abu-El-Rub, Josh Gray, Huy Anh Pham, Yujia Zhou, Frank J Manion, Mei Liu, Xing Song, Hua Xu, Masoud Rouhizadeh, Yaoyun Zhang
June 12, 2021

The COVID-19 pandemic swept across the world rapidly, infecting millions of people. An efficient tool that can accurately recognize important clinical concepts of COVID-19 from free text in electronic health…

How do we share data in COVID-19 research? A systematic review of COVID-19 datasets in PubMed Central Articles.

Xu Zuo, Yong Chen, Lucila Ohno-Machado, Hua Xu
March 22, 2021

OBJECTIVE: This study aims at reviewing novel coronavirus disease (COVID-19) datasets extracted from PubMed Central articles, thus providing quantitative analysis to answer questions related to dataset contents, accessibility and citations.…

A smartphone-based online tool for prehospital self-triage of COVID-19.

Juan Yu, Han-Wen Zhang, Yuan-Kai Shao, Yi Lei, Huan Chen, Zu-Hui Pu, Fan Lin, Hua-Jian Xu, Yu-Li Wang, Chao Liang, Li-Hong Liu, Xia-Jing Liu, Wei-Cai Dai
November 16, 2020

The COVID-19 epidemic has swept across China and spread to other countries. The rapid spreading of COVID-19 and panic combined with the lack of a hierarchical medical system in China…

Existing drug treatments cannot significantly shorten the clinical cure time of children with COVID-19.

Mengting Li, Yang Wang, Hua Xu, Changlin Liu, Liang Shi, Qi Ye, Jun Wang, Sichan Li, Yan Mei, Liuliu Gao
September 30, 2020

INTRODUCTION: COVID-19 has become a global health security issue, it has caused more than half a million deaths worldwide so far, the treatment strategies are the most concerned issues for…

Risk Assessment and Prevention of Severe Acute Respiratory Syndrome Coronavirus 2 Transmission for Hospitalized Urological Patients After the COVID-19 Pandemic in Wuhan, China.

Ejun Peng, Ding Xia, Wenxi Gao, Ying Zhan, Huan Yang, Xiaoqi Yang, Hua Xu, Xiaoling Qu, Jie Sun, Shaogang Wang, Zhangqun Ye, Kun Tang, Zhiqiang Chen
July 30, 2020

BACKGROUND: Emerging asymptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections were detected and multiple cases were found to be SARS-CoV-2 positive again, which raised an alarm for the patients…

Structures of potent and convergent neutralizing antibodies bound to the SARS-CoV-2 spike unveil a unique epitope responsible for exceptional potency

Shuo Du, Yunlong Cao, Qinyu Zhu, Guopeng Wang, Xiaoxia Du, Runsheng He, Hua Xu, Yinghui Zheng, Bo Wang, Yali Bai, Chenggong Ji, Ayijiang Yisimayi, Qisheng Wang, Ning Gao, Sunney Xie, Xiao-dong Su, Junyu Xiao
July 9, 2020

Understanding the mechanism of neutralizing antibodies (NAbs) against SARS-CoV-2 is critical for effective vaccines and therapeutics development. We recently reported an exceptionally potent NAb, BD-368-2, and revealed the existence of…

Immediate psychological distress in quarantined patients with COVID-19 and its association with peripheral inflammation: A mixed-method study.

Qian Guo, Yuchen Zheng, Jia Shi, Jijun Wang, Guanjun Li, Chunbo Li, John A Fromson, Yong Xu, Xiaohua Liu, Hua Xu, Tianhong Zhang, Yunfei Lu, Xiaorong Chen, Hao Hu, Yingying Tang, Shuwen Yang, Han Zhou, Xiaoliang Wang, Haiying Chen, Zhen Wang, Zongguo Yang
May 19, 2020

Since the end of 2019, Corona Virus Disease 2019 (COVID-19) has been the cause of a worldwide pandemic. The mental status of patients with COVID-19 who have been quarantined and…

Coronavirus disease 2019 in children: Characteristics, antimicrobial treatment, and outcomes.

Hui Peng, Ping Gao, Qiong Xu, Maochang Liu, Jing Peng, Yang Wang, Hua Xu
May 7, 2020

BACKGROUND: At present, coronavirus disease 2019 (COVID-19) has spread in many countries. We conducted this study to help pediatricians understand the conditions of COVID-19 in children. METHODS: We retrospectively summarized…

The profile of peripheral blood lymphocyte subsets and serum cytokines in children with 2019 novel coronavirus pneumonia.

Hui Li, Kailan Chen, Maochang Liu, Hua Xu, Qiong Xu
April 20, 2020

OBJECTIVES: The study was aimed at investigating the characteristics of peripheral blood lymphocyte subsets and serum cytokines in children with 2019 novel coronavirus (2019-nCoV) pneumonia. METHODS: Children with 2019-nCoV pneumonia…

Aggravated Respiratory Failure From COVID-19 Infection: Patient Care Management From Nurses in the Intensive Care Unit.

Jianying Xiong, Shanggan Zeng, Hua Xu, Ying Cao
January 1, 1970

CONTEXT: About 19% of COVID-19-patients undergo hypoxic breathing problems, approximately 14% require intensive oxygen therapy, and 5% require mechanical ventilation and ICU admission. These patients can deteriorate rapidly, so nurses…

[A retrospective analysis of medication in children with SARS-CoV-2 infection in Wuhan, China].

Zhao-Song DU, Hua Xu, Mao-Chang Liu
January 1, 1970

OBJECTIVE: To study the medication in children with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in Wuhan, China, and to provide a reference for rational drug use in clinical…

Coronavirus: indexed data speed up solutions.

Lucila Ohno-Machado, Hua Xu
January 1, 1970

[Analysis of clinical characteristics of patients with different vaccines and underlying diseases infected with novel coronavirus Omicron variant].

Hua Xu, Jingjing Wang, Hongmei Gao, Yongqiang Wang
January 1, 1970

OBJECTIVE: To analyze the clinical characteristics of patients inoculated with different vaccines and underlying diseases, infected with the novel coronavirus Omicron variant. METHODS: The data of 430 patients infected with…